Retrotransposition gene L1-FGGY and application thereof as marker of lung squamous cell carcinoma

A technology of L1-FGG and retrotransposition, applied in the field of DNA recombination, can solve the problem of no reports on the occurrence and development of lung squamous cell carcinoma

Active Publication Date: 2018-11-13
TIANJIN MEDICAL UNIV CANCER INST & HOSPITAL
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  • Abstract
  • Description
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Problems solved by technology

Although the replication and transposition of LINE-1 can lead to genetic diseases including tumors, there is no report on its impact on the development of lung squamous cell carcinoma

Method used

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  • Retrotransposition gene L1-FGGY and application thereof as marker of lung squamous cell carcinoma
  • Retrotransposition gene L1-FGGY and application thereof as marker of lung squamous cell carcinoma
  • Retrotransposition gene L1-FGGY and application thereof as marker of lung squamous cell carcinoma

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Experimental program
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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0025] 1. Nucleic acid sequence

[0026] L1-FGGY retrotransposable gene sequence:

[0027]

[0028] 2. Experimental method

[0029] 1. Clinical Sample Collection

[0030] The present invention collected a total of 110 samples of lung squamous cell carcinoma patients who received partial lung resection from October 2004 to October 2006 in the Department of Lung Oncology. Among the 110 samples of lung squamous cell carcinoma, 52 samples had their adjacent normal tissues collected at the same time. The patients included 89 men and 20 women with a median age of 62 years (39-84 years). These patients were all diagnosed as squamous cell carcinoma of the lung, and the clinical stage was stage I in 30 cases, stage II in 34 cases, stage III in 35 cases, and stage IV in 10 cases). No treatment including chemotherapy or radiotherapy was given before lung...

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Abstract

The invention discloses retrotransposition gene L1-FGGY and application thereof as a marker of lung squamous cell carcinoma. The nucleic acid sequence of the retrotransposition gene L1-FGGY is SEQ IDNO. 1; the nucleic acid sequence of an upstream detection primer of the retrotransposition gene L1-FGGY is SEQ ID NO. 2; and the nucleic acid sequence of a downstream detection primer is SEQ ID NO. 3.A retrotransfer inhibitor nevirapine or efavirenz can inhibit the expression level of the retrotransposition gene L1-FGGY for treatment of lung squamous cell carcinoma. The retrotransposition gene L1-FGGY disclosed can be used as a new tumor marker, and the detection of L1-FGGY can be used for early diagnosis, molecular typing and prognosis evaluation of lung squamous cell carcinoma, and L1-FGGYcan also become a potential therapeutic target for clinical treatment of lung squamous cell carcinoma and has broad application prospects.

Description

technical field [0001] The invention relates to DNA recombination technology, more specifically a retrotransposable gene L1-FGGY and its use as a marker for lung squamous cell carcinoma. Background technique [0002] Lung cancer is the most common malignant tumor. Its morbidity and mortality are among the highest in the world. The 5-year survival rate is only about 15.6%. The main reason is that about 75% of patients are diagnosed with advanced lung cancer. Underdiagnosis contributes to the poor prognosis of lung cancer patients. Non-small cell lung cancer (NSCLC) accounts for more than 85% of lung cancers, mainly including lung adenocarcinoma, lung squamous cell carcinoma and large cell lung cancer, of which lung squamous cell carcinoma accounts for about 30% of NSCLC. In recent years, the in-depth study of tumor molecular markers such as EGFR and ALK has greatly promoted the molecular diagnosis and targeted therapy of lung adenocarcinoma. However, there is a lack of effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/54A61K31/551A61K31/536A61P35/00
CPCA61K31/536A61K31/551A61P35/00C12N9/1241C12Q1/6886C12Q2600/158
Inventor 于津浦刘芃芃张蕊
Owner TIANJIN MEDICAL UNIV CANCER INST & HOSPITAL
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