Pharmaceutical composition for treating periocular melanin deposition

A composition and technology of melanin, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as listlessness and image impact, and achieve the effect of simple acquisition, easy acceptance and good effect

Inactive Publication Date: 2018-11-16
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Deep melanosis around the eye circles will make people look listless and affect the image. Therefore, the development of new safe and effective external products for the treatment of melanosis around the eye circles has good social and economic benefits

Method used

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  • Pharmaceutical composition for treating periocular melanin deposition
  • Pharmaceutical composition for treating periocular melanin deposition
  • Pharmaceutical composition for treating periocular melanin deposition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] At room temperature, take 3.0 kg of auricularia oxhide, 2.5 kg of purple back gold plate, 1.5 kg of white spot gunknife, 1.5 kg of Sperancae, 1.5 kg of golden camellia, 1.5 kg of half-side flag, 1.5 kg of golden ear, 1.5 kg of Chinese green 1.5 kg of ox gallbladder, mix the above-mentioned medicines evenly. Add water and decoct 3 times, the amount of water added for the first time is 8 times the weight of the drug, the extraction time is 3 hours, the amount of water added for the second and third times is 6 times the weight of the drug, and the extraction time is 2 hours, the drug is obtained Composition extract; the drug extract is concentrated under reduced pressure to a relative density of 1.10-1.20 (50°C), cooled to room temperature to obtain a pharmaceutical composition concentrate; the pharmaceutical composition concentrate is filtered, and the filtrate is equipped with polystyrene-di Chromatography of vinylbenzene macroporous resin, so that the effective componen...

Embodiment 2

[0038] The pharmaceutical composition extract obtained in Example 1 is used to prepare the essence for the treatment of melanosis around the eye circle, and the weight percentage of the components is as follows:

[0039]

[0040]

[0041] Production process: Add sodium hyaluronate into water and stir to disperse evenly, then add other ingredients in turn, and stir evenly at 70°C.

[0042] The matrix components used in the preferred embodiment of the present invention are as described above, the matrix components used in this embodiment can maximize the efficacy of the pharmaceutical composition of the present invention. But the commonly used substrates that can be applied to cosmetics produced by other manufacturers can also be used in the present invention, as long as the dosage meets the national cosmetic additive dosage standard, it will not affect the effect of the present invention, so they are not listed one by one.

[0043] The homogeneous emulsification equipment...

Embodiment 3

[0045] In this study, by observing the effect of the pharmaceutical composition extract of the present invention on melanosis around the eye circles, the curative effect of the pharmaceutical composition extract of the present invention on the treatment of melanosis around the eye circles is verified at the human level. The essence used in the experiment The essence containing 1% extract of the pharmaceutical composition of the present invention prepared for Example 2.

[0046] 1. Materials and methods

[0047] 1.1 Case selection of patients with melanosis around the eye circles This clinical study was carried out in the outpatient department of Guixi Hospital of Traditional Chinese Medicine, Jiangxi Province, from August 2015 to July 2018. A total of 56 female patients, aged 20 to 40 years old, participated in this study , with an average age of (33.24±4.56) years, including 48 cases with Fitzpatrick type III skin and 8 cases with type IV skin. Melanosis around the eye socke...

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Abstract

The invention discloses a pharmaceutical composition for treating periocular melanin deposition, a preparation method thereof and application thereof. The invention is characterized in that the pharmaceutical composition is prepared from the following raw materials (by weight): 290-310 parts of cynanchum auriculatum royle ex wight, 200-360 parts of Ajuga nipponensis, 140-160 parts of Hypoestes sanguinolenta ''White Spot'', 140-160 parts of garden balsam stem, 140-160 parts of Camellia nitidissima Chi., 140-160 parts of semi-pinnated brake herb, 140-160 parts of Carpesium divaricatum, and 140-160 parts of tinospora sinensia. Raw materials of the pharmaceutical composition are easily available, and the preparation method is convenient. It proves through clinical test results that the pharmaceutical composition has a good effect of treating periocular melanin deposition, is easy to accept by customers, and has a good application prospect and a market prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and application, in particular to a cosmetic pharmaceutical composition capable of treating melanosis around the eyes, its preparation method and application. Background technique [0002] Melaninosis around the eye circles is commonly known as "dark circles". The skin around the eyes is the thinnest, and the melanin activity is very vigorous. Coupled with aging, external stimuli and other factors, various problems are prone to occur. Melanosis around the eye circles is caused by staying up late, mood swings, eye fatigue, and aging, resulting in too slow blood flow in the blood vessels of the eye skin, resulting in stagnation, insufficient oxygen supply to the tissues, and excessive accumulation of metabolic waste in the blood vessels, resulting in eye pigmentation. The skin around the eyes is very thin and ages quickly, and there are many capillaries underneath. In addit...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K8/9789A61K8/9749A61P17/16A61Q19/00
CPCA61K36/12A61K36/185A61K36/19A61K36/27A61K36/28A61K36/47A61K36/53A61K36/59A61K36/82A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2800/84A61Q19/00A61Q19/005A61K8/9749A61K8/9789A61P17/16A61K2300/00
Inventor 王恩瀚陈汉坤吴诗耀
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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