Method for preparing starch nano-hydrogel
A technology of starch nano and hydrogel, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of high energy consumption, long reaction time, high cost, etc., achieve a firm gel network structure, improve gel The effect of degree of chemicalization and mild preparation conditions
Inactive Publication Date: 2018-11-20
QINGDAO AGRI UNIV
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Problems solved by technology
This method takes a long time to react, the shape of the particles is mostly flakes, the specific surface area is not ideal, and a large amount of acidic wastewater will be generated.
Starch nanoparticles can also be prepared by high pressure homogenization, electrospray and other methods, but the above methods have low yield, high energy consumption and high cost
Method used
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Embodiment 1-3
[0032] The original starch (pea, corn, potato starch) was dissolved in 100ml of deionized water to prepare a 10% starch solution. The starch suspension was placed in boiling water and heated for 30 minutes, and stirred continuously with a glass rod to completely gelatinize the starch. According to the addition ratio of oil-water ratio of 3:7, take 30ml of starch solution and 70ml of soybean oil respectively, then add 1% emulsifier Span80, mix evenly, and homogenize for 3 minutes to obtain colostrum. Ultrasound the colostrum for 20-30s with an ultrasonic cleaner, place it in a refrigerator at 4°C, and regenerate it (6, 12, 24, and 36h). Deionized water was used to break the emulsion, centrifuged, and the precipitate was taken, washed once with ethanol with a concentration of 50%, and then washed once with ethanol with a concentration of 80%, and the precipitate was taken, and the precipitate was quickly frozen with liquid nitrogen, freeze-dried at low temperature and vacuum, O...
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Abstract
The invention relates to a method for preparing starch nano-hydrogel. The method comprises the following steps: 1) pasting the original starch, mixing with an oil phase, homogenizing to obtain initialmilk, performing ultrasonic treatment, and putting the obtained starch nano-particle solution into a refrigerator for resuscitating; 2) adding deionized water into the original starch nano-particle solution for demulsification, centrifuging, taking the precipitate, washing with ethanol, taking the precipitate, rapidly freezing the precipitate with liquid nitrogen, and performing low-temperature vacuum freeze drying, thereby obtaining the dried starch nano-hydrogel. The method disclosed in the invention is simple, green and efficient, the whole original starch solution before formation of gelagglomerate is infinitely subdivided into nano-scale W / O water droplets under the external force effects of shear, ultrasonic treatment and the like, the starch solution is gradually gelatinized in tiny water droplets, the starch gelatinization degree is improved, and the gel network structure is firm. Due to the characteristics that the nano-particles can be directly swallowed by epithelial cellsand the like, the prepared starch nano-particle hydrogel serves as an active material or drug carrier to be researched.
Description
technical field [0001] The invention belongs to the technical field of hydrogel preparation, in particular to a preparation method of starch nano hydrogel Background technique [0002] Hydrogels are three-dimensional polymeric networks that can absorb and maintain a large amount of water, and are widely used in food, cosmetics, biomedicine, as well as bone tissue and drug loading. Nanoscale hydrogels have the characteristics of larger specific surface area, nanopore size, larger pore volume, and can be directly phagocytized by epithelial cells. The research as active substances or drug carriers has very important practical significance. The nano-carrier system can effectively improve the sustained-release effect, bioavailability and activity of active substances. [0003] Hydrogels need to have high strength and flexibility when applied, as well as reversible deformation properties. However, ordinary chemically cross-linked polymer hydrogels are brittle and break easily un...
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IPC IPC(8): C08J3/075C08B30/18A61K47/36C08L3/02
CPCA61K47/36C08B30/18C08J3/075C08J2303/02
Inventor 孙庆杰秦洋李曼王梦薇熊柳姬娜邱立忠卞希良孙纯锐
Owner QINGDAO AGRI UNIV