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Application of formononetin

A technology for formononetin and pulmonary fibrosis, which is applied in the directions of medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc., to achieve good therapeutic effects, easy acceptance, and easy access.

Inactive Publication Date: 2018-11-23
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no report that formononetin can slow down pulmonary fibrosis

Method used

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  • Application of formononetin
  • Application of formononetin
  • Application of formononetin

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Experimental program
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Effect test

Embodiment 1

[0033] The establishment of embodiment 1 mouse pulmonary fibrosis model and pharmacodynamics detection experimental method and steps:

[0034] 1. Establishment of mouse pulmonary fibrosis model

[0035] The 36 mice were randomly divided into three groups, blank control group (normal saline group / normal control group), pulmonary fibrosis model group (bleomycin), and formononetin group (administration of formononetin after modeling anthocyanin), 12 rats in each group.

[0036] Pulmonary fibrosis animal model preparation refers to male C57BL / 6J, (age 8-10 weeks) wild-type mice, with 10% chloral hydrate by intraperitoneal injection of 0.5ml / 100g to give mice anesthesia, intratracheal invasive injection of 2U / Kg bleomycin. The specific implementation method is as follows: after the mouse is anesthetized, weigh and record, fix the mouse on the operating table, disinfect the neck with 70% alcohol, use a scalpel to make a vertical wound of about 1 cm in the neck of the mouse, and u...

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PUM

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Abstract

The invention provides application of formononetin in preparing drug for treating pulmonary fibrosis, which is the novel application of formononetin. According to the invention, the formononetin has good effect for pulmonary fibrosis, has no adverse reaction, can slow down the pulmonary fibrosis of mice induced by the bleomycin and has a good application prospect for treating, slowing down or improving the pulmonary fibrosis.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the application of formononetin containing formononetin. Background technique [0002] Organ fibrosis is a pathological change in which fibrous connective tissue increases and parenchymal cells decrease in organ tissues caused by various acute and chronic diseases, and is a common pathological feature of many chronic diseases. Sustained progression of fibrosis can lead to organ structural damage and functional decline, and organ failure caused by fibrosis of parenchymal organs (such as heart, liver, lung, kidney, etc.) is the main cause of disability and death in patients. According to relevant statistical data in the United States, nearly 45% of the patients who died of various diseases in developed countries can be attributed to tissue fibroproliferative diseases. Pulmonary fibrosis is an important component of visceral fibrosis, which is triggered by chronic, recurrent and ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00
CPCA61K31/352A61P11/00
Inventor 饶子和漆敏杨诚周红刚孙涛李霄鹤高晶晶刘帅帅黄梦莹毛家贺吕紫薇黄凯
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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