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A kind of method for extracting gastrodin by high-pressure supercritical carbon dioxide

A carbon dioxide, supercritical technology, applied in chemical instruments and methods, organic chemistry, production of bulk chemicals, etc., can solve the problems of unsuitable gastrodin extraction, low gastrodin extraction rate, etc., and achieves less environmental pollution and shorter production process. Production cycle, high purity effect

Active Publication Date: 2021-05-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the supercritical extraction of gastrodin, and traditional supercritical CO 2 The maximum extraction pressure of the extraction is 40MPa, which is suitable for the extraction of conventional fat-soluble components, but not for the extraction of gastrodin, and the extraction rate of gastrodin is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for extracting gastrodin with high-pressure supercritical carbon dioxide, comprising crushing gastrodia elata medicinal material to a particle size of 200 mesh and then loading it into high-pressure supercritical CO 2 In the extraction tank of the extraction equipment, the extraction tank and the separation tank are heated separately. When the temperatures of the extraction tank and the separation tank reach 50°C and 50°C respectively, the CO 2 Drive into the extraction kettle and the separation kettle with a high-pressure pump, adjust the valve to make the pressure of the extraction kettle and the separation kettle reach 65MPa and 11MPa respectively, and start the circular extraction. After the pressure and temperature are stable, pump in ethanol with a volume fraction of 95% and start timing. The dosage of the entrainer in Gastrodia elata medicinal material is 1.5ml, and the extraction time is 60min. After the extraction is completed, the gastrodin extract is ...

Embodiment 2

[0022] A method for extracting gastrodin with high-pressure supercritical carbon dioxide, comprising crushing gastrodia elata medicinal material to a particle size of 80 mesh and then loading it into high-pressure supercritical CO 2 In the extraction tank of the extraction equipment, the extraction tank and the separation tank are heated separately. When the temperatures of the extraction tank and the separation tank reach 65°C and 35°C respectively, the CO 2 Drive into the extraction kettle and the separation kettle with a high-pressure pump, adjust the valve to make the pressure of the extraction kettle and the separation kettle reach 35MPa and 14MPa respectively, and start the circular extraction. After the pressure and temperature are stable, pump in ethanol with a volume fraction of 50% and start timing. The amount of entrainer in Gastrodia elata medicinal material is 3ml, and the extraction time is 120min. After the extraction is completed, the material is discharged from...

Embodiment 3

[0024] A method for extracting gastrodin with high-pressure supercritical carbon dioxide, comprising crushing the medicinal material Gastrodia elata to a particle size of 120 mesh and then loading it into high-pressure supercritical CO 2 In the extraction tank of the extraction equipment, the extraction tank and the separation tank are heated separately. When the temperatures of the extraction tank and the separation tank reach 35°C and 60°C respectively, the CO 2 Use a high-pressure pump to drive into the extraction kettle and the separation kettle, adjust the valves to make the pressure of the extraction kettle and the separation kettle reach 50MPa and 6MPa respectively, start the circular extraction, and start timing, the extraction time is 60min, after the extraction is completed, discharge the material from the separation kettle and collect Gastrodia elata Vegetarian extract. Through analysis and detection, according to the content of gastrodin in Gastrodia elata and the ...

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Abstract

The invention discloses a method for extracting gastrodin by high-pressure supercritical carbon dioxide. 2 In the extraction kettle of the extraction equipment, the extraction kettle and the separation kettle are respectively heated to the extraction temperature, and the CO 2 Use a high-pressure pump to pump into the extraction kettle and the separation kettle, adjust the valves to make the extraction kettle and the separation kettle reach the set pressure respectively, and start the circular extraction. After the set parameters are stable, pump the entrainer and start timing. The dosage is 0-3ml. After the extraction is completed, the gastrodin extract is discharged from the separation tank and collected. The invention improves the extraction rate of gastrodin through high-pressure supercritical carbon dioxide extraction, shortens the production cycle of gastrodin, has simple and convenient operation, less solvent consumption, easy separation, and less environmental pollution in the production process, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of extracting chemical components of Chinese medicinal materials, in particular to a method for extracting gastrodin with high-pressure supercritical carbon dioxide. Background technique [0002] Gastrodia elata, as a precious Chinese herbal medicine, has a medicinal history of more than two thousand years in my country. At present, research at home and abroad has found that gastrodin, the main component of Gastrodia elata, can treat pain, dizziness, numbness of limbs, convulsions and other diseases. It mainly treats arterial insufficiency, vestibular neuron inflammation, vertigo, coronary heart disease and so on. [0003] At present, the traditional techniques for extracting gastrodin mainly include alcohol extraction, microwave extraction, ultrasonic extraction and enzyme extraction. The ubiquitous problems in the prior art are mainly the low extraction rate of gastrodin, low product output content, and co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203C07H1/08
CPCC07H1/08C07H15/203Y02P20/54
Inventor 段明慧葛发欢阮培均马晋芳史庆龙李海池方婷
Owner SUN YAT SEN UNIV