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Synthetic opioid vaccine

A vaccine, conjugation technology, in the field of synthetic opioid vaccines

Inactive Publication Date: 2018-11-23
THE SCRIPPS RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[3] In addition, the ease of fentanyl synthesis has enabled the illicit production and creation of drug analogues

Method used

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  • Synthetic opioid vaccine
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Embodiment

[0058] Chemical

[0059] Unless otherwise stated, NMR was measured on a Bruker 400 instrument ( 1 H NMR (400MHz), 13 C NMR (100 MHz)) spectrum. 1 H NMR chemical shifts are reported in parts per million (ppm) relative to chloroform (7.26 ppm), and coupling constants are expressed in Hertz (Hz). The following abbreviations are used for spin multiplicity: s = singlet, d = doublet, t = triplet, q = quartet, m = multiplet, br = broad. 13 C NMR chemical shifts are reported in ppm relative to the triplet centerline at 77.0 ppm for chloroform. Electrospray ionization (ESI) masses were acquired on a ThermoFinnigan LTQ Ion Trap. Matrix-assisted laser desorption / ionization (MALDI) mass spectra were acquired on an Applied Biosystems Voyager DE. Assay plates pre-coated in Merck (0.25 mm thick, silica gel 60F 254 ) by analytical thin-layer chromatography (TLC). In pre-coated with silicone 60F 254 Preparative TLC (PTLC) separations were performed on Merck analytical plates (0.50 mm t...

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Abstract

Fentanyl is an addictive prescription opioid that is over 80 times mora potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous designer drug analogues that escapetoxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, we report an effectiveimmunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross-reactivity for a wide panel of fentanyl analogues, Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug specificity profiling of antibodies derived directly from serum. Our newly developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 62 / 281,262, filed January 21, 2016, the disclosure of which is incorporated herein by reference in its entirety. [0003] The inventor's related patent applications include: [0004] US12 / 374908, PCT07 / 074976, WO08 / 016976, "Vaccines and methods for controlling obesity"; [0005] US09 / 038546, PCT09 / 038546, WO09 / 120954, "Nicotine Conjugates"; [0006] US13 / 984230, PCT12 / 000079, WO12 / 108960, "Grelin-mimetic polypeptide hapten immunoconjugates with improved solubility and immunogenicity and methods of use thereof"; [0007] US13 / 261217, PCT10 / 002489, WO11 / 031327, "nicotine haptens, immunoconjugates and uses thereof"; [0008] US14 / 367511, PCT11 / 001997, WO13 / 095321, "Heroin Haptens, Immunoconjugates and Related Uses"; [0009] US14 / 901794, PCT14 / 045019, WO15 / 002929, "Methods and compositions for treating obesity"; [0010] US14 / 901799, PCT14 / 0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/00
CPCC07K1/00A61K39/385A61K47/6829A61K39/0013A61K2039/55505A61K2039/55561C07K16/44C07K2317/92A61P25/30A61P37/04A61K47/643A61K39/395
Inventor 金姆·D·扬达
Owner THE SCRIPPS RES INST
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