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Miniature blood detector for rapidly detecting acute myocardial infarction marker, and detection method thereof

A technology of acute myocardial infarction and markers, applied in biological testing, instruments, measuring devices, etc., can solve the problems of time-consuming

Active Publication Date: 2018-11-30
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the clinical detection of acute myocardial infarction markers needs to go through the steps of whole blood anticoagulation collection, serum extraction, etc., before they can be sent to the immune analyzer for biochemical testing, which takes a long time and requires professional operators to intervene and participate in the detection intermittently process

Method used

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  • Miniature blood detector for rapidly detecting acute myocardial infarction marker, and detection method thereof
  • Miniature blood detector for rapidly detecting acute myocardial infarction marker, and detection method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A miniature blood detector for rapid detection of acute myocardial infarction markers, characterized in that it consists of a blood sampling port 1, a blood separator 2, a serum sampling port 3, an immunoadsorption reactor 4, and a pH sensitive field effect tube 5 and a micro-current detection circuit 6; the blood sampling port 1 is located on the top of the blood separator 2; the blood separator 2 is an airtight cylindrical tube inserted above the top cover of the immunoadsorption reactor 4, and the upper and lower ends are sealed by the upper end 7 and the lower end sealing plug 8 are sealed, and a blood separation membrane 9 is placed inside, and the bottom of the blood separator 2 is a serum outlet 3; a pH sensitive field effect tube 5 is placed at the bottom of the immunoabsorption reactor; the pH sensitive field effect tube 5 is composed of drain 10, source 11, gate 12 and pH sensitive film 13; the drain, source and gate of the field effect transistor 5 are respect...

Embodiment 2

[0029] The structure of the miniature blood detector for rapid detection of acute myocardial infarction markers in the present invention is the same as that in Example 1.

[0030] The blood separator 2 is an airtight cylindrical tube. The material is plastic. The bottom diameter is 1.5cm and the height is 4cm.

[0031] The blood separation membrane inside the blood separator is an ultra-thin nano-structure membrane layer prepared on a hollow fiber support body, and its material is alumina ceramics, and its structure is a hollow tubular structure. The outer diameter size is 2.5mm, the inner diameter is 0.7mm, the length is 5cm, and the pore diameter is 0.06μm.

[0032]The structure of the immunoadsorption reactor is a columnar reaction pool made of plastic, with a bottom diameter of 3 cm, an inner diameter of 2.5 cm, and a height of 2.5 cm.

[0033] The bottom of the immune adsorption reactor is equipped with a pH-sensitive field effect transistor 5. The gate material is InG...

Embodiment 3

[0037] A miniature blood detector (built-in type) for rapid detection of markers of acute myocardial infarction, characterized in that it consists of a blood sampling port 1, a blood separation membrane 9, an immunoadsorption reactor 4, a pH sensitive field effect tube 5 and The microcurrent detection circuit 6 is composed of; the blood sampling port 1 is located at the top of the immunoabsorption reactor 4 and is sealed by the upper sealing plug 7; the blood separation membrane 9 is an ultra-thin sheet membrane placed inside the immunoabsorption reactor 4, and its diameter The inner diameter of the immunoadsorption reactor is the same, the edge is sealed, and it is located below the top cover of the immunoadsorption reactor and above the liquid level; the bottom end of the immunoabsorption reactor 4 is equipped with a pH sensitive field effect tube 5; the pH sensitive field effect tube 5 is formed by a drain electrode 10 , source 11, grid 12, and pH sensitive film 13; the drai...

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Abstract

The invention relates to a miniature blood detector for rapidly detecting an acute myocardial infarction marker, and a detection method thereof. The miniature blood detector comprises a blood sample inlet (1), a blood separator (2), a serum sample outlet (3), an immunoadsorption reactor (4), a pH-sensitive field effect transistor (5) and a micro-current detection circuit (6); the blood sample is injected from the sample inlet (1), and flows through a blood separation membrane (9), serum enters the immunoadsorption reactor (4), an acute myocardial infarction marker antigen in the serum specifically binds to its antibody, and is cross-linked with an enzyme in order to cause the change of the pH value of a reaction solution in order to change the current signal of the pH-sensitive field effect transistor (5), the current signal is output by the micro-current detection circuit (6), and the concentration of the measured marker is displayed. The concentration of the acute myocardial infarction marker is detected by using whole blood as a biological sample, combining a membrane separation technology with a micro biosensor element, integrating the blood separation membrane with the micropH-sensitive field effect transistor, performing an electronic enzyme-linked immunosorbent reaction and adopting current response as an output in order to quickly and easily achieve clinical detectionof acute myocardial infarction.

Description

technical field [0001] The invention belongs to the fields of medical inspection, biosensing principles and microelectronic technology, and relates to a micro-blood detector and a detection method for rapid detection of markers of acute myocardial infarction, aiming to design a fast and convenient A miniature blood detector for accurately detecting markers of acute myocardial infarction. Background technique [0002] Cardiovascular disease is a serious disease that endangers human health and life. Around the world, 17 million people die from cardiovascular disease every year. According to the statistics in the "China Cardiovascular Disease Report 2016", the current number of cardiovascular disease patients in my country is about 290 million, ranking first in the death rate of various diseases, accounting for more than 40% of the residents' disease deaths, and continues to rise. Acute myocardial infarction is a major cardiovascular disease, its onset is sudden, and the morta...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68G01N33/6887G01N2333/4712G01N2800/324
Inventor 金万勤王轶卿储震宇
Owner NANJING UNIV OF TECH
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