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Application of interventional medical devices and aphidicolin

A technology of aphidicolin and medical equipment, which is applied in the field of interventional medical equipment and aphidicolin, and can solve problems such as toxic and side effects

Active Publication Date: 2022-03-11
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs themselves have toxic side effects on other organs in the body or generally require higher concentrations to achieve the purpose of preventing or treating restenosis, which brings certain side effects

Method used

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  • Application of interventional medical devices and aphidicolin
  • Application of interventional medical devices and aphidicolin
  • Application of interventional medical devices and aphidicolin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065]Aphidicolin was dissolved in DMSO solution to prepare a solution of aphidicolin with a concentration of 100 mg / mL. 100 mg of PLGA was dissolved in 10 mL of n-propyl acetate solvent to prepare a PLGA solution (drug sustained-release carrier solution) with a concentration of 10 mg / mL. Take 100 μL of aphidicolin solution and add it into 10 mL of PLGA solution to prepare a final solution with aphidicolin concentration of 1 mg / mL. The final solution was sprayed onto the surface of the L605 stent by ultrasonic spraying, and the content of aphidicolin per unit area on the surface of the stent was 10 μg / mm 2 .

Embodiment 2

[0067] Dissolve aphidicolin in DMSO solution to prepare a solution of aphidicolin with a concentration of 1 mg / mL. The aphidicolin solution was sprayed onto the surface of the stent by ultrasonic spraying. The content of aphidicolin per unit area on the surface of the stent is 10 μg / mm 2 .

Embodiment 3

[0069] Aphidicolin and PLA were simultaneously dissolved in DMSO solution to prepare a final solution with aphidicolin concentration of 10 μg / mL and PLA concentration of 10 mg / mL. Spray the final solution onto the surface of the stent by ultrasonic spraying. The content of aphidicolin per unit area on the surface of the stent is 113ng / mm 2 .

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Abstract

The invention relates to an interventional medical device and the application of aphidicolin. An interventional medical device includes a device body and drugs loaded on the device body. The active drug in the medicine is selected from at least one of aphidicolin, a pharmaceutically acceptable salt of aphidicolin, a solvate of aphidicolin, and aphidicolin derivatives. The inventors discovered unexpectedly that when aphidicolin is loaded on the surface of the interventional device, it can effectively inhibit the growth of smooth muscle cells, there is no obvious hyperplasia of the vascular intima, and the toxicity to the surrounding cells is small, so as to prevent or treat Restenosis after transluminal vascular angioplasty provides a new option.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an interventional medical device and the application of aphidicolin. Background technique [0002] Percutaneous transluminal angioplasty is currently the most effective means of treating vascular blockage. However, after percutaneous transluminal angioplasty using traditional bare metal stents, stent expansion is likely to cause excessive proliferation of vascular smooth muscle cells. After surgery, 20% ~30% probability of vascular restenosis, resulting in secondary danger. Other interventional medical devices, such as occluders, artificial valves, etc., may cause cell proliferation at the intervention site if they cause damage to the tissue endothelium at the intervention site during the interventional treatment operation, affecting the effect of the interventional treatment. Some methods are to load drugs that are toxic to cells on the surface of the device to inhibit cell proli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L29/16A61L27/54A61K31/047A61K31/436A61K31/337A61L27/28A61L29/08A61P9/00A61P35/00
CPCA61L27/28A61L27/54A61L29/08A61L29/16A61L31/08A61L31/16A61K31/047A61K31/337A61K31/436A61L2300/216A61L2300/606A61L2300/416A61K2300/00
Inventor 王玄李俊菲陈陆
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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