Composite biological active material used for maxillofacial defect repair and preparation method thereof

Abstract

The invention discloses a composite biological active material used for maxillofacial defect repair and a preparation method thereof. The method comprises the following steps: putting a polyether-ether-ketone film into an acetone solution to heat and reflow for 12 hours, continuously stirring, sequentially taking out, ultrasonically cleaning for 30 minutes by using acetone, water and 75% alcohol to obtain an intermediate product A; dissolving collagen into a 0.1-1% acetic acid solution to prepare a 0.1-3% collagen solution, performing dialysis in a PBS buffer solution until the solution is neutral, thereby obtaining an intermediate product B; adding decalcified human dental matrix particles into the intermediate product B to uniformly stir, thereby obtaining an intermediate product C; putting the intermediate product A into the intermediate product C to cross-link and freeze-dry. The composite material avoids the defect that mechanical dynamic property of DTM and collagen is poor, haselastic modulus and tensile strength which are close to those of a bone tissue, and has good bone induction effect. Moreover, the composite material further can avoid immunological rejection, reducespostoperative repair failure probability, and relieves pains of a patient.

Description

technical field [0001] The invention relates to the technical field of bone repair, in particular to a composite bioactive material for repairing maxillofacial defects and a preparation method thereof. Background technique [0002] Maxillofacial trauma, inflammation, tumors and other reasons often cause bone defects in varying degrees, and severe cases lead to facial deformities, which have adverse effects on the quality of life and mental health of patients. Autologous bone has been considered the most effective bone repair material because of its osteoinductive activity and non-immunogenicity. However, the lack of autologous bone sources often causes secondary damage to patients, so the clinical application is limited. Allograft bone and xenograft bone are currently widely used bone repair materials, but there are risks such as immunogenicity and disease transmission. Since the 21st century, researchers have synthesized a variety of chemically synthesized bone repair mat...

AI Technical Summary

Problems solved by technology

However, chemically synthesized bone has disadvantages such as immune rejection, non-degradable or poor osteoinductivity.