Preparation method of gambogic acid

A technology of gambogic acid and gambogic acid, which is applied in the field of preparation of gambogic acid, can solve the problems of low extraction yield, large loss of active ingredients, and high cost, and achieve the effects of high separation efficiency, cost reduction, and solvent consumption reduction

Inactive Publication Date: 2018-12-21
湖州展舒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the extraction process of gambogic acid is complicated, the loss of active ingredients is large,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0014] Example 1

[0015] The method for preparing gambogic acid designed in the present invention specifically includes the following steps:

[0016] (1) Garcinia cambogia, a Chinese medicinal material, is dried, crushed, sieved, and put into an extraction container;

[0017] (2) Extract twice with ethanol reflux, combine the extracts, recover the ethanol and concentrate to an appropriate amount;

[0018] (3) Load the extract into a device with a weakly polar macroporous adsorption resin for adsorption, and then inject water and ethanol in turn for elution;

[0019] (4) Silica separation treatment;

[0020] (5) Crystal refining treatment;

Example Embodiment

[0021] Example 2

[0022] The method for preparing gambogic acid designed in the present invention specifically includes the following steps:

[0023] (1) Garcinia cambogia, a Chinese medicinal material, is dried, crushed, sieved, and put into an extraction container;

[0024] (2) Extract 3 times with acetone reflux, combine the extracts, recover the propanol and concentrate to an appropriate amount;

[0025] (3) Load the extract into a device with a weakly polar macroporous adsorption resin for adsorption, and then inject water and ethanol in turn for elution;

[0026] (4) Silica separation treatment;

[0027] (5) Crystal refining treatment;

Example Embodiment

[0028] Example 3

[0029] The method for preparing gambogic acid designed in the present invention specifically includes the following steps:

[0030] (1) Garcinia cambogia, a Chinese medicinal material, is dried, crushed, sieved, and put into an extraction container;

[0031] (2) Reflux extraction with ether for 3 times, combine the extracts, recover the ether and concentrate to an appropriate amount;

[0032] (3) Load the extract into a device with a weakly polar macroporous adsorption resin for adsorption, and then inject water and ethanol in turn for elution;

[0033] (4) Silica separation treatment;

[0034] (5) Crystal refining treatment.

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PUM

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Abstract

The invention discloses a preparation method of gambogic acid. The preparation method specifically comprises the following steps that (1) the traditional Chinese medicine resina garciniae morellae isdried, smashed, sieved and packed into an extraction container; (2) the resina garciniae morellae is subjected to reflux extraction for several times by using an organic solvent, the extraction liquidis combined, the organic solvent is recycled, the extraction liquid is concentrated to be at the appropriate amount; (3) the extraction liquid is packed into a device with the weak polarity microporous adsorption resin to be adsorbed, eluant is injected into the device to conduct elution; (4) silica gel separation treatment is conducted; and (5) crystallization and refining treatment is conducted. The preparation method of gambogic acid replaces a traditional extraction method with adsorption of weak polarity microporous adsorption resin, thus the using amount of the solvent is decreased, andenvironmental protection and cost reduction are achieved. Meanwhile, the method is simple, convenient and rapid, the separation efficiency is high, and a good effect is achieved.

Description

technical field [0001] The invention relates to a method for extracting and preparing components of Chinese herbal medicines, in particular to a method for preparing gambogic acid. Background technique [0002] Garcinia cambogia is a gelatinous resin that flows out after the trunk of the Garcinia cambogia plant is cut. It is one of the commonly used traditional Chinese medicines. It is mainly used for swelling, ulcers, eczema, tumors, stubborn diseases and other diseases. It has a good curative effect in folk medicine. Its chemical composition is mainly composed of gambogic acid, neogambogic acid, allogambogic acid and so on. In the prior art, the extraction process of gambogic acid is complex, the loss of active ingredients is large, the extraction yield is low, the cost is high, and the resources of Chinese medicinal materials are largely wasted. Contents of the invention [0003] In order to solve the above problems, the present invention proposes a method for preparin...

Claims

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Application Information

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IPC IPC(8): C07D493/20
CPCC07D493/20
Inventor 吴建华
Owner 湖州展舒生物科技有限公司
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