Multi-component coaxial printing sprayer

A printing nozzle and multi-component technology, which is applied in the field of 3D printing, can solve the problems affecting the position accuracy of micro-droplet injection, not using multi-component injection control, and the coaxiality of the nozzle cannot be guaranteed, etc., to achieve simple design, The effect of simple structure and low manufacturing difficulty

Active Publication Date: 2018-12-21
ZHEJIANG UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this nozzle is that each nozzle needs to be welded, which is difficult to manufacture, and cannot be replaced and matched at will.
[0007] In some existing inventions and devices of coaxial air pressure nozzles, the effect of air shearing on reducing the size of sprayed droplets has been basically realized, but the coaxiality of the inner and outer nozzles is often not guaranteed.
Some existing methods to ensure the coaxiality of the inner and outer nozzles are often to add a limit structure between the two nozzles, which greatly affects the stability of the airflow in the middle, thereby affecting the accuracy of the spray position of the micro-droplets
Moreover, the existing inventions and devices do not use multi-component injection control, lack of real-time control of multiple material loading and heterogeneous distribution of printed structures
Often only biological structures of uniform composition can be produced

Method used

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  • Multi-component coaxial printing sprayer
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  • Multi-component coaxial printing sprayer

Examples

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specific example

[0072] Gel microspheres containing different cell ratios (human umbilical cord vascular endothelial cells and human bone marrow mesenchymal stem cells) are produced in large quantities with the multi-component coaxial printing nozzle of the present invention, and the effect of the difference of the two cell ratios on the growth of vascular endothelial cells is studied. Effects of vascularization characterization and calcification of bone marrow mesenchymal stem cells.

[0073]Step 1. Prepare all parts, soak the top cover, positioning seat, multi-component positioning components, Luer connector, silicone sealing ring, inner nozzle, and outer nozzle in 75% medical alcohol in advance, seal and wrap it with a container, and place it Treat in an ultrasonic cleaning machine for more than 10 minutes to remove foreign matter such as surface oxide layer and oil layer. Then take it out and place it on a clean bench, wash it three times with deionized water, and dry it in the air. For t...

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Abstract

The invention discloses a multi-component coaxial printing sprayer. The multi-component coaxial printing sprayer comprises a coaxial air pressure sprayer main body and a multi-component locating module, wherein the coaxial air pressure sprayer main body is fixed with an inner sprayer and an outer sprayer; at least two liquid feeding channels in sealing butt joint with the inner sprayer are arranged in the multi-component locating module; a duct, through which the inner sprayer is penetrated, is formed in the coaxial air pressure sprayer main body; an air feeding channel is formed between an outer wall of the inner sprayer and an inner wall of the duct; an air inlet which is connected with the air feeding channel is formed on the coaxial air pressure sprayer main body. The multi-component coaxial printing sprayer disclosed by the invention has the characteristics of high biological compatibility, small design size, convenience in dismounting, sterilizing and cleaning, easiness in assembling, high stability, adjustable multi-component, and the like, and has superior prospect in the fields of cell medical research, in vitro organ research, three-dimensional tissue printing research, and the like.

Description

technical field [0001] The invention relates to the technical field of 3D printing, in particular to a multi-component coaxial printing nozzle. Background technique [0002] As people pay more and more attention to their own health and disease research, tissue engineering and regenerative medicine have ushered in a period of rapid development in the past ten years. Among them, with the emergence of cell printing and the reports of related research results, the topic of biomanufacturing has attracted more and more attention and attention. The discovery of new materials and the invention of new manufacturing processes enable researchers to carry out targeted treatments for an increasingly wide range of surgical diseases, realize the regeneration of damaged tissues and organs, and greatly improve the ability of human disease treatment and the sense of well-being of the whole people. [0003] The most extensive basis for clinical medical research is human cells. In the past few...

Claims

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Application Information

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IPC IPC(8): C12M3/00B33Y30/00
CPCC12M33/00B33Y30/00
Inventor 贺永赵海明傅建中
Owner ZHEJIANG UNIV
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