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Improved silk fibroin biocompatible polyurethane membranes

A biocompatible, silk fibroin technology, applied in fiber treatment, tissue regeneration, ear implants, etc., can solve problems affecting mechanical properties and achieve enhanced solubility and durability

Active Publication Date: 2018-12-21
EAR SCI INST AUSTRALIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, adding blending components to affect mechanical properties remains a challenge in many cases

Method used

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  • Improved silk fibroin biocompatible polyurethane membranes
  • Improved silk fibroin biocompatible polyurethane membranes
  • Improved silk fibroin biocompatible polyurethane membranes

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Embodiment approach

[0068] The silk fibroin membrane matrix prepared according to the present invention is biodegradable, biocompatible, and compared with most other natural and synthetic biomaterials (such as collagen and polylactic acid (PLA)) in its mechanical strength, One or more of elongation and stiffness are improved.

[0069] a. silk fibroin membrane matrix

[0070] The invention provides a silk fibroin biocompatible polyurethane film matrix. The film matrix of the present invention exhibits higher extensibility than silk films lacking biocompatible polyurethane.

[0071] The membranes of the present invention are made for the repair of perforated tympanic membranes, especially chronic perforations. Additionally or alternatively, the membranes of the present invention may be fabricated for the repair of a subject's ear canal, particularly the flaccidity and / or scutum. Preferably, the membrane is fabricated for delivery of a device particularly suited for repairing the eardrum.

[0...

Embodiment 1

[0257] The preparation of embodiment 1-silk foam

[0258] Undegummed fibers from the polymorphic silkworm (Bombyx mori) on reels were purchased from a production center in northeastern India. Fibers were degummed using 2 g / L sodium carbonate (Sigma-Aldrich, St. Louis, MO, USA) and 1 g / L odorless castile soap (Vasse Virgin, Wilyabrup, Western Australia, Australia) at 98°C for 30 min. Degumming was performed using a rotary staining machine (Ahiba IR Pro, Datacolor, Lawrenceville, USA). The degummed fibers were dried overnight at 40 °C and then dissolved with 9.3 M LiBr at 60 °C for 5 h. With deionized water (dH 2 O) The dissolved silk solution was dialyzed at 4°C for 3 days to obtain an aqueous silk solution with a concentration between 4 and 5% w / v as calculated by gravimetric analysis. The silk solution from each batch was diluted to 4% w / v and then pipetted into tubes, 20 mL in each tube. The solution was frozen in a -80 °C freezer for 24 h. The frozen tubes were removed...

Embodiment 2

[0259] The preparation of the silk fibroin / polyurethane film of embodiment 2-blending

[0260] Freeze-dried silk foam was chopped into small pieces with a scalpel and added to sterile centrifuge tubes along with polyurethane pellets. Then, both materials were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) for 5 hours at room temperature on a rotary mixer. The amounts of silk, polyurethane and HFIP used were calculated such that the final concentration of the two materials was 5% (w / v) polyurethane and 1.25% (w / v) silk fibroin (or 1:4 silk:polyurethane). The dissolved samples were centrifuged at 7000 xg for 2 min to remove air bubbles, then cast into 55 mm diameter petri dishes and allowed to dry in a fume hood for 24 h. All films had a final thickness of 100 μm.

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Abstract

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

Description

technical field [0001] The present invention relates to the preparation of membranes for repairing the middle ear, including tympanic membrane perforations and injuries. More specifically, the present invention provides compositions and methods for preparing silk fibroin biocompatible polyurethane films with improved biodegradation, mechanical, and vibroacoustic properties using solvents. Background technique [0002] The following discussion is intended only to facilitate an understanding of the present invention. The discussion is not an acknowledgment or admission that any of the material referred to is or was part of the common general knowledge as of the priority date of this application. [0003] Chronic perforation of the eardrum or tympanic membrane is relatively common and requires surgical intervention with graft material to cover the perforation, a technique known as type 1 myringoplasty or tympanoplasty. [0004] Autografts such as muscle fascia, fat, perichond...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/26A61L27/36A61L27/50C08J5/18D06M15/564
CPCA61L27/26A61L27/36A61L27/44A61L27/50A61F2/18A61L27/14A61L27/3604A61L27/3804A61L27/54A61F2002/183A61L2430/14A61L27/225A61L2300/40C08L75/04C08L89/04
Inventor M·阿特拉斯B·阿勒代斯R·迪莉R·拉杰霍瓦
Owner EAR SCI INST AUSTRALIA
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