114 results about "Middle ear structure" patented technology

The automatic tremella pedicle cutting device comprises the machine frame, the conveying mechanism, the lifting mechanism and the cutting mechanism, the conveying mechanism is arranged in the machine frame, mushroom sticks enter the conveying mechanism, the height of the mushroom sticks is not changed due to the clamping effect of a conveying belt, and the mushroom sticks are cut off. In the conveying process, tremella fuciformis leaves growing on the fungus sticks are gradually lifted by the first supporting plate and the second supporting plate from the height close to or lower than the upper surfaces of the fungus sticks, at the moment, the tremella fuciformis leaves are in a stretched state, and meanwhile, the lifted parts of the tremella fuciformis leaves are gradually increased along with the gradual reduction of the limiting channel between the first supporting plate and the second supporting plate in the longitudinal direction; when the tremella fuciformis is cut off, the length of the tremella fuciformis is gradually increased from the edge positions of the two side faces in the lengthwise direction of the fungus stick to the position close to the middle ear base, after the leaf close to the ear base position is lifted to a certain height, the ear base at the bottom of the tremella fuciformis is exposed, and a cutting space is formed, so that the cutting mechanism is matched to cut off the ear base in the tremella fuciformis. Meanwhile, the ear pedicles can be completely cut off, and economic benefits are good.

The invention provides an otological disease auxiliary diagnosis large model construction method and a large model system, and relates to the technical field of multi-modal learning modeling, and the method comprises the following steps: building four diagnosis sub-models, comprising a hearing loss evaluation model, an auditory meatus and tympanic membrane / middle ear state or lesion evaluation model, an auditory meatus and middle ear structure evaluation model and a medical history and medical record model. The four diagnosis sub-models are trained; the outputs of the four diagnosis sub-models are fused, and a large ear disease clinical diagnosis model is constructed; evaluating and optimizing the performance of the otological disease clinical diagnosis large model; according to the method, multiple sub diagnosis models are fused, multi-source heterogeneous data are used for training, the generalization ability of the model can be improved, the model can adapt to different application scenes, the decision process of the model can be better understood by analyzing the output of each sub diagnosis model, and the credibility of the model is improved.

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a formulation to a targeted site under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

The invention provides a mouse middle ear epithelium 3D organoid and a construction method thereof, and is characterized in that the method comprises the following steps: a, taking a bubble structure of a mouse middle ear tissue, cleaning, digesting, filtering, centrifuging filtrate, collecting precipitate, and separating primary cells of the mouse middle ear; and b, inoculating the digested single cells and cell agglomerates into a 24-pore plate, wrapping with matrigel, and carrying out 3D culture, wherein a medium is a middle ear epithelium amplification medium. And culturing for about 3-5 days to obtain the mouse 3D middle ear proliferation type organoid. And performing differentiation culture by using a middle ear epithelium differentiation medium to obtain the mouse middle ear epithelium organ. According to the method, the 3D mouse middle ear epithelium organ is successfully constructed, the physiological and pathological processes of the middle ear are conveniently analyzed and researched, the interaction between the middle ear microenvironment and cells can be more accurately simulated, and the application range is wide as a model.

The present disclosure provides an endoscopic apparatus and associated methods. The apparatus may include a steerable tool having a first flexible tube concentrically nested within a second flexible tube. The apparatus may include an end cap disposed on the steerable tool, an image sensor disposed on the end cap, and one or more light sources disposed on the end cap. The apparatus may be configured for accessing a region within a middle ear cavity of a patient. As such, the apparatus may further include a flexible tube, through which the steerable tool may extend, as well as a pre-curved rigid tube, through which the flexible tube may extend, thus allowing the apparatus to be deployed for middle ear access.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.

The invention relates to the technical field of crossing of medical instruments and artificial intelligence, and provides a hearing threshold detection method based on multi-mode hearing electrophysiological signal fusion. Comprising stimulation frequency otoacoustic emission and auditory brainstem response induced by sweep frequency stimulation sound, distortion product otoacoustic emission induced by dual-tone stimulation and middle ear sound immittance / reflection signals, and a multi-task deep learning model is constructed to perform fusion analysis on the signals. According to the method, accurate quantitative regression prediction of hearing thresholds with any frequency resolution and automatic classification and discrimination of hearing loss properties are synchronously realized, the problems of single evaluation dimension and insufficient complex hearing loss analysis ability in the prior art are effectively solved, the comprehensiveness, accuracy and clinical operation efficiency of objective hearing evaluation are remarkably improved, and the method is suitable for popularization and application. And an innovative system solution is provided for fine diagnosis of the auditory function.

An apparatus including an actuator, such as a piezoelectric actuator, and a first tissue interface device and a second tissue interface device spaced away from the first tissue fixation device, wherein the apparatus is at least a partially extra-middle ear cavity dual bone interface force based implantable tissue stimulation portion of a hearing prosthesis.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The present invention relates to the field of medical device technology, and in particular to a middle ear tympanic cavity effusion suction device, comprising a puncture needle, the bottom end of the puncture needle is fixedly connected to a hose, the right end of the hose is fixedly connected to a suction port of a suction tube, the puncture needle and the outer side of the suction tube are jointly provided with an auxiliary fixing mechanism, the auxiliary fixing mechanism comprises a movable seat, a deceleration and limiting mechanism is provided at the upper left end of the movable seat, a rotating seat is rotatably provided on the inner side of the connecting plate near the upper end, and a high-efficiency negative pressure mechanism is provided at the bottom end of the rotating seat and on the outer side of the hose. The present invention installs the puncture needle, the hose and the suction tube on the auxiliary fixing mechanism, thereby realizing precise position adjustment of the puncture needle according to the position of the tympanic membrane of different patients, the deceleration and limiting mechanism ensures the controllable puncture speed and depth, and the high-efficiency negative pressure mechanism can effectively control the air and liquid circulation state inside the hose through the forward button and the reverse button.

The invention relates to an ear catheter for introduction into an auditory tube, comprising a catheter cartridge (2) having at least three lumens, a first lumen as an administration lumen (2a) for drug administration, a second lumen as a dilation lumen (2b) for dilating the balloon (17), and a third lumen as a pressure relief lumen (2c) for relieving pressure in the middle ear region. In order to prevent the outflow of the drug from the administration lumen (2a) and in order to prevent the outflow of the dilation fluid from the dilation lumen (2b), corresponding one-way valves (11, 12) are provided, and a pressure limiter (13) is provided in order to limit the pressure of the balloon.

The utility model discloses a tympanic sinus flusher which comprises an outer tube, an inner tube and a water supply device, the front end of the outer tube is bent to form a bent tube section, the included angle alpha between the axis OA of the tube opening position of the bent tube section and the center line OB of the outer tube is 90-180 degrees, the width d of the bent tube section is 2-10mm, the inner tube is located in the outer tube, and the water supply device is located in the inner tube. The front end of the inner pipe extends into the bent pipe section and is flush with a pipe opening in the bent pipe section or exposed out of the pipe opening, the rear end of the inner pipe is exposed out of the rear end of the outer pipe in the axial direction, a water outlet of the water supply device is communicated with the rear end of the inner pipe, and a limiting stopper used for limiting the inner pipe to move towards the inside of the outer pipe in the axial direction is arranged between the outer pipe and the inner pipe. The utility model provides a tympanic sinus flusher. The tympanic sinus flusher can be used for flushing the tympanic sinus position in a middle ear through an external auditory canal of a patient.

A middle ear implant system includes a disc-shape vibration surface that is configured for implantation within skin lying over skull bone of a patient, with the disc-shape vibration surface parallel to an outer surface of the skin and to the skull bone so that sound vibrations striking the outer surface of the skin create corresponding vibrations in the disc-shape vibration surface within the skin. A rigid ossicle connector has a proximal end connected to the disc-shape vibration surface and a distal end connected to an ossicle in the middle ear of the patient so that vibrations of the disc-shape vibration surface are mechanically coupled to the ossicle for perception by the patient as sound.

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a formulation to a targeted site under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

This invention relates to the field of neuroscience research and biomedical engineering experimental equipment, and discloses a stereotaxic brain localization device suitable for turtles and its usage method. The device includes an original base plate, an extended base plate assembly connected by splicing, a turtle shell limiting assembly mounted on the base plate, a curved platform, a modified semi-circular ear rod, a mouth clamp with an endotracheal intubation port, and a magnetic skull leveler. This invention expands the operating space through the extended plate and uses an arc-shaped limiting baffle to fix the turtle's position; the specially designed semi-circular ear rod adapts to the shallow concave middle ear structure of turtles, avoiding damage; the mouth clamp integrates height and length adjustment functions and has a reserved endotracheal intubation channel to maintain the experimental animal's respiration; the magnetic skull leveler can precisely adjust the head level using four corner nuts. This device enables precise localization of turtle brain regions and electrode implantation, providing stable and accurate hardware support for turtle movement regulation and neuroscience research.

The application discloses a kind of middle ear organoids culture medium and culture method, belong to organoids technical field.The middle ear organoids culture medium includes: basic culture medium, specific additive factor, CHIR99021 and TTNPB;Specific additive factor includes the following end concentration components: SB203580, 1-20 mmol / L;SB431542, 50-1000 nmol / L;Y-27632, 1-20 mmol / L;FGF-10, 10-30 μg / L;RS-246204, 1-20 nmol / mL and the like.Culture method includes: middle ear tissue is handled to obtain middle ear cell, after middle ear cell is resuspended, with matrigel is mixed, then inoculation, after it coagulates, the above-mentioned middle ear organoids culture medium is added and is cultivated, obtains middle ear organoids.The culture medium of the application can simultaneously improve the quantity and survival rate of middle ear organoids, conducive to industrialized production.

This invention discloses a device for attaching an optical element, such as an otoscope, to a smartphone for diagnosing and / or identifying problems in the outer ear, middle ear, and / or ear canal of a patient. The device may include a body. The body may include a hole and a first engagement member configured to engage with a second engagement structure belonging to the optical element. A first surface may be attached to the body and configured to contact a first smartphone surface. A piston may be provided, which may include a second surface parallel to the first surface and configured to contact a second smartphone surface. A threaded knob may be provided, connected to the piston through the hole.

The utility model relates to the field of middle ear analyser, more specifically, relate to a novel middle ear analyser positive and negative air pressure mechanical device, including air nozzle and gas supply device, the air nozzle is connected with gas supply device through the micro -adjusting air pipe, the micro -adjusting air pipe is equipped with fixed magnetic ring one side close to the air nozzle, is equipped with the sliding magnetic ring on the micro -adjusting air pipe one side close to gas supply device, the utility model discloses a novel middle ear analyser positive and negative air pressure mechanical device, relative to traditional technology, because air nozzle and gas supply device no longer directly connect, but adopt the micro -adjusting air pipe and connect, because the diameter of micro -adjusting air pipe is determined when producing, therefore only need to determine the total length of micro -adjusting air pipe and the distance of sliding magnetic ring and fixed magnetic ring, can adjust the accurate volume, because the volume is determined through the pipe length x radius square x pi, and such structural error is less, and the adjustment is convenient.

An apparatus includes a first portion configured to attach to a target middle ear portion of a recipient's body. The apparatus also includes an elongated second portion that is rigidly fixed to and extends from the first portion. The second portion has an end portion configured to be rigidly secured to a transducer assembly having a longitudinal axis. The second portion extends from the transducer assembly at an angle greater than 30 degrees relative to the longitudinal axis. The first portion and the second portion are configured to respond to a first vibration displacement of the target middle ear portion by providing a second vibration displacement to the transducer assembly. The second vibration displacement is greater than the first vibration displacement.

This invention discloses a wearable ultrasound delivery device for treating otitis media, comprising a wearable main body with a flexible structure adapted to the shape of the patient's ear canal, and a through-hole central channel; an ultrasound drug delivery device, detachably disposed within the central channel, comprising a drug carrier for carrying the therapeutic drug to be delivered, an ultrasound transducer assembly for providing an ultrasound-guided drug delivery mode, and a handheld controller for adjusting the millimeter-level displacement of the drug carrier into the middle ear cavity; wherein, the ultrasound transducer assembly comprises a flexible substrate and multiple piezoelectric transducer units integrated on the flexible substrate, the multiple piezoelectric transducer units constituting a phased array transducer array. This device solves the technical problems of inaccurate drug delivery, low drug delivery efficiency, inability to adapt to the ear canal structure, and complex operation in the prior art.

The present application relates to the technical field of artificial implant medical device surface modification and middle ear hearing reconstruction, and discloses a processing method for enhancing the fixing stability of an artificial auditory ossicle prosthesis, the prosthesis and application. The method comprises the following steps: after the surface of the auditory ossicle prosthesis in contact with the middle ear tissue is cleaned, a polydopamine layer is formed in a basic dopamine solution, then gelatin, hyaluronic acid or cellulose sulfate is connected to the surface of the polydopamine layer through a carbodiimide activation system to form a viscous functional layer, and the dry sponge-like structure is obtained through freeze-drying. The functional layer can quickly rehydrate and restore the adhesion state after contacting with human blood or tissue fluid, thereby improving the fixing stability of the artificial auditory ossicle prosthesis in the initial implantation stage and reducing the risk of displacement or dislocation.

A device and method for treating a middle ear disorder in a patient includes providing to the patient an intraoral vibration device having a mouthpiece for contacting an oral cavity of the patient, wherein the intraoral vibration device has a frequency tuned to treat the middle ear disorder, and providing instructions for using the intraoral vibration device. The instructions provided for using the intraoral vibration device include placing the mouthpiece over at least one portion of the oral cavity, and applying a vibratory force at the frequency to treat the middle ear disorder.

An apparatus for detecting ear structure movements or changes, or changes in pressure in the ear-canal of a user, in order to control or affect the function of an associated device. The apparatus includes a sensor apparatus capable of being worn by the user to be located in or adjacent an ear-canal of the user. The sensor apparatus includes at least one sensor being located and configured to detect and capture sensor data relating to middle ear, ear-drum complex, ear-drum margin, and / or other ear structure movements or changes of characteristics, or changes in pressure in the ear-canal of the user. A device is provided for processing and analysing sensor data from the sensor apparatus. The device analyses sensor data concerning: eye movement or directional auditory attention or focus data, and / or voluntary control data.

The utility model relates to the technical field of scalpels, and discloses a middle ear muscle cutting knife assembly which comprises a knife body and a storage box used for storing the knife body, the knife body comprises a knife handle, a knife rod and a knife head, the knife handle and the knife rod are both of a cylindrical structure, an inclined connecting rod is arranged at the end of the knife handle, the connecting rod is connected with the knife rod, and the knife head is connected with the knife rod. The tool bit is arranged at the end, away from the tool handle, of the tool bar. The whole storage box is of a square structure, the interior of the storage box is hollow, the upper portion of the storage box is open, and a cover body is arranged at the opening in a sliding mode; a plurality of groups of limiting seats are arranged on the side wall of the storage box, and the cutter bars are clamped in the limiting seats; the cutting knife provided by the utility model is used for cutting two small middle ear muscles, and the inclined connecting rod is matched with the knife rod, so that the knife head can be in a middle ear tympanic chamber when the knife handle is held by a hand, and the use is convenient; and the storage box can be used for the cutter body, so that the cutter body can be well stored, and the cutter body is prevented from being influenced by the outside.

The utility model discloses a tympanic membrane ventilation pipe which comprises a pipe body, a ventilation pipe body and a ventilation pipe body. The first limiting part is arranged at the upper end of the tube body and used for limiting the interior of the tympanic membrane; the second limiting part is arranged at the lower end of the tube body and used for limiting the exterior of the tympanic membrane, the second limiting part comprises a left limiting strip and a right limiting strip, and a clamping cake is arranged on the right limiting strip. A marking layer is arranged outside the clamping cake, and the marking layer is one or combination of more of a reflective coating, a metal coating and a magnetic coating. The first limiting part is symmetrically arranged in a flow guide groove in the pipe body, and an arc-shaped opening is formed in the center of the flow guide groove. And a slope is arranged at the end part of the diversion trench. The left limiting strip and the right limiting strip are adopted to form the second limiting part, the situation that the tympanic membrane ventilation pipe falls into the middle ear is effectively eradicated, the pipe body is short, the blocking phenomenon is effectively avoided, meanwhile, the ventilation holes are additionally formed in the side portion of the pipe body, and the situation that ventilation cannot be achieved due to pipe body blocking is further avoided.

The present invention discloses a device and method for measuring middle ear impedance for clinical audiometry research in a wide frequency range of ambient pressure, which is based on MEMS microphone technology and uses a pressure-pressure probe to measure sound pressure waves and corresponding sound velocity waves.

The present invention discloses a special installation fixture for an eardrum-stimulating artificial middle ear actuator, comprising a shell, a tube body fixed to the shell, and a displacement limiting frame connected to the tube body; two congruent long holes are formed on the outer surface of the displacement limiting frame, and a limit pin is inserted into the two long holes for sliding engagement, and a section of the limit pin between the two long holes is set as a hinge section, and the hinge section is connected with a connecting block and two matching clips, and the rear part of the clip is connected to the connecting block through a hydraulic piston cylinder, and the hydraulic piston cylinder is equipped with a control device; one end of the limit pin is connected to a push rod, and the outer surface of the displacement limiting frame is connected to a support, and a limiting through hole is provided on the support, and the push rod is slidably engaged with the limiting through hole, and a support spring is provided between the limit pin and the support, and a scale line is provided for the moving stroke of the push rod. Through the arrangement of the displacement limiting frame and the support spring, the installer can control the relative contact force between the actuator and the eardrum when installing, so that the actuator can be installed anytime and anywhere.

The utility model relates to the technical field of medical equipment, in particular to a double-channel tympanic membrane puncture needle. When in use, all the components of the device are assembled firstly, the limiting bead is adjusted to be located in the second groove, the second connecting channel is kept to be located below the first connecting channel, puncture is conducted, after the needle head punctures the tympanic membrane, the piston of the first needle cylinder is moved backwards, a low-pressure area is created, middle ear pus is sucked, and after suction is completed, the first needle cylinder and the second needle cylinder are separated from each other. The second needle cylinder is pushed, the limiting bead located in the second groove moves into the first groove under the pushing force of the liquid medicine, the second connecting channel is opened, the liquid medicine is injected into the middle ear, needle cylinder replacement or secondary puncture is not needed in the whole process, operation is simplified, the tympanic membrane trauma possibility is reduced, and meanwhile the operation efficiency and safety are improved.

There is presented a hearing device for being placed at least partially in an ear canal. The hearing device includes a rechargeable battery, and at least two charging areas on the surface of the hearing device, the charging areas enabling recharging the rechargeable battery by applying a voltage from one charging area to another charging area. At least one charging area is positioned on the hearing device at the end of the hearing device facing into the middle ear during use and optionally out of contact with the walls of the ear canal during use.

The application discloses a tympanic ventilation tube with spiral locking, multiple waterproof and valve control drainage functions, and belongs to the field of ear implant medical devices. The ventilation tube comprises a tube body, an implant device interface is arranged at the outermost end of the tube body, a one-way duckbill valve is arranged at the end close to the external auditory canal, micro-flow ventilation holes are distributed in the circumferential direction of the side wall, a flexible sealing sheet is arranged on the outer side of the tube body, and a continuous single-ring gradually-changing asymmetric spiral fixing structure is arranged on the outer periphery of the middle ear cavity. The spiral fixing structure induces the radial flanging of the tympanic membrane tissue to be embedded between the spiral structure and the outer wall of the tube body to form axial locking through the asymmetric section, and realizes gradual release when reversely rotating through the rise angle, tooth height and round angle gradient; the sealing sheet realizes stable adhesion and controllable peeling through the thickness gradient, pre-stress and surface energy gradient; the micro-flow ventilation holes and the duckbill valve constitute a gas-liquid separation double channel, realize low-resistance ventilation, liquid blocking and pressure-driven drainage. The application can realize stable fixation, water-tight sealing, controllable ventilation, one-way drainage and low-damage implantation and removal.