79 results about "Middle ear structure" patented technology

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a formulation to a targeted site under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

The present disclosure provides an endoscopic apparatus and associated methods. The apparatus may include a steerable tool having a first flexible tube concentrically nested within a second flexible tube. The apparatus may include an end cap disposed on the steerable tool, an image sensor disposed on the end cap, and one or more light sources disposed on the end cap. The apparatus may be configured for accessing a region within a middle ear cavity of a patient. As such, the apparatus may further include a flexible tube, through which the steerable tool may extend, as well as a pre-curved rigid tube, through which the flexible tube may extend, thus allowing the apparatus to be deployed for middle ear access.

The invention belongs to the field of biological medicine research and development, discloses a method and a system for collecting and analyzing auditory electrophysiological data of experimental animals, and is particularly suitable for non-human primates. The method comprises the following steps: delivering a drug to a middle ear cavity through an external auditory canal, and synchronously recording auditory electrophysiological data before and after drug administration; aBR and DPOAE multi-mode detection is adopted, and the frequency range of 4 kHz to 32 kHz is covered; setting anesthesia depth and three-electrode positioning to reduce interference; optimizing the signal-to-noise ratio through noise suppression and dynamic signal superposition; an auditory threshold database is constructed, and a machine learning model is combined to judge an injured part. The system integrates a multi-modal stimulation module, a minimally invasive drug delivery device and a data analysis platform, and supports cross-species data compatibility. The accuracy of otology medicine research is remarkably improved, the surgical operation risk is avoided, and the method is suitable for gene therapy, ototoxicity screening and other scenes.

The invention relates to the technical field of crossing of medical instruments and artificial intelligence, and provides a hearing threshold detection method based on multi-mode hearing electrophysiological signal fusion. Comprising stimulation frequency otoacoustic emission and auditory brainstem response induced by sweep frequency stimulation sound, distortion product otoacoustic emission induced by dual-tone stimulation and middle ear sound immittance / reflection signals, and a multi-task deep learning model is constructed to perform fusion analysis on the signals. According to the method, accurate quantitative regression prediction of hearing thresholds with any frequency resolution and automatic classification and discrimination of hearing loss properties are synchronously realized, the problems of single evaluation dimension and insufficient complex hearing loss analysis ability in the prior art are effectively solved, the comprehensiveness, accuracy and clinical operation efficiency of objective hearing evaluation are remarkably improved, and the method is suitable for popularization and application. And an innovative system solution is provided for fine diagnosis of the auditory function.

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and / or inner ear. Methods of treating diseases or disorders of the middle ear and / or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

The present invention relates to the field of medical device technology, and in particular to a middle ear tympanic cavity effusion suction device, comprising a puncture needle, the bottom end of the puncture needle is fixedly connected to a hose, the right end of the hose is fixedly connected to a suction port of a suction tube, the puncture needle and the outer side of the suction tube are jointly provided with an auxiliary fixing mechanism, the auxiliary fixing mechanism comprises a movable seat, a deceleration and limiting mechanism is provided at the upper left end of the movable seat, a rotating seat is rotatably provided on the inner side of the connecting plate near the upper end, and a high-efficiency negative pressure mechanism is provided at the bottom end of the rotating seat and on the outer side of the hose. The present invention installs the puncture needle, the hose and the suction tube on the auxiliary fixing mechanism, thereby realizing precise position adjustment of the puncture needle according to the position of the tympanic membrane of different patients, the deceleration and limiting mechanism ensures the controllable puncture speed and depth, and the high-efficiency negative pressure mechanism can effectively control the air and liquid circulation state inside the hose through the forward button and the reverse button.

The utility model discloses a tympanic sinus flusher which comprises an outer tube, an inner tube and a water supply device, the front end of the outer tube is bent to form a bent tube section, the included angle alpha between the axis OA of the tube opening position of the bent tube section and the center line OB of the outer tube is 90-180 degrees, the width d of the bent tube section is 2-10mm, the inner tube is located in the outer tube, and the water supply device is located in the inner tube. The front end of the inner pipe extends into the bent pipe section and is flush with a pipe opening in the bent pipe section or exposed out of the pipe opening, the rear end of the inner pipe is exposed out of the rear end of the outer pipe in the axial direction, a water outlet of the water supply device is communicated with the rear end of the inner pipe, and a limiting stopper used for limiting the inner pipe to move towards the inside of the outer pipe in the axial direction is arranged between the outer pipe and the inner pipe. The utility model provides a tympanic sinus flusher. The tympanic sinus flusher can be used for flushing the tympanic sinus position in a middle ear through an external auditory canal of a patient.

A middle ear implant system includes a disc-shape vibration surface that is configured for implantation within skin lying over skull bone of a patient, with the disc-shape vibration surface parallel to an outer surface of the skin and to the skull bone so that sound vibrations striking the outer surface of the skin create corresponding vibrations in the disc-shape vibration surface within the skin. A rigid ossicle connector has a proximal end connected to the disc-shape vibration surface and a distal end connected to an ossicle in the middle ear of the patient so that vibrations of the disc-shape vibration surface are mechanically coupled to the ossicle for perception by the patient as sound.

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a formulation to a targeted site under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

This invention relates to the field of neuroscience research and biomedical engineering experimental equipment, and discloses a stereotaxic brain localization device suitable for turtles and its usage method. The device includes an original base plate, an extended base plate assembly connected by splicing, a turtle shell limiting assembly mounted on the base plate, a curved platform, a modified semi-circular ear rod, a mouth clamp with an endotracheal intubation port, and a magnetic skull leveler. This invention expands the operating space through the extended plate and uses an arc-shaped limiting baffle to fix the turtle's position; the specially designed semi-circular ear rod adapts to the shallow concave middle ear structure of turtles, avoiding damage; the mouth clamp integrates height and length adjustment functions and has a reserved endotracheal intubation channel to maintain the experimental animal's respiration; the magnetic skull leveler can precisely adjust the head level using four corner nuts. This device enables precise localization of turtle brain regions and electrode implantation, providing stable and accurate hardware support for turtle movement regulation and neuroscience research.

The application discloses a kind of middle ear organoids culture medium and culture method, belong to organoids technical field.The middle ear organoids culture medium includes: basic culture medium, specific additive factor, CHIR99021 and TTNPB;Specific additive factor includes the following end concentration components: SB203580, 1-20 mmol / L;SB431542, 50-1000 nmol / L;Y-27632, 1-20 mmol / L;FGF-10, 10-30 μg / L;RS-246204, 1-20 nmol / mL and the like.Culture method includes: middle ear tissue is handled to obtain middle ear cell, after middle ear cell is resuspended, with matrigel is mixed, then inoculation, after it coagulates, the above-mentioned middle ear organoids culture medium is added and is cultivated, obtains middle ear organoids.The culture medium of the application can simultaneously improve the quantity and survival rate of middle ear organoids, conducive to industrialized production.

This invention discloses a device for attaching an optical element, such as an otoscope, to a smartphone for diagnosing and / or identifying problems in the outer ear, middle ear, and / or ear canal of a patient. The device may include a body. The body may include a hole and a first engagement member configured to engage with a second engagement structure belonging to the optical element. A first surface may be attached to the body and configured to contact a first smartphone surface. A piston may be provided, which may include a second surface parallel to the first surface and configured to contact a second smartphone surface. A threaded knob may be provided, connected to the piston through the hole.

The utility model relates to the field of middle ear analyser, more specifically, relate to a novel middle ear analyser positive and negative air pressure mechanical device, including air nozzle and gas supply device, the air nozzle is connected with gas supply device through the micro -adjusting air pipe, the micro -adjusting air pipe is equipped with fixed magnetic ring one side close to the air nozzle, is equipped with the sliding magnetic ring on the micro -adjusting air pipe one side close to gas supply device, the utility model discloses a novel middle ear analyser positive and negative air pressure mechanical device, relative to traditional technology, because air nozzle and gas supply device no longer directly connect, but adopt the micro -adjusting air pipe and connect, because the diameter of micro -adjusting air pipe is determined when producing, therefore only need to determine the total length of micro -adjusting air pipe and the distance of sliding magnetic ring and fixed magnetic ring, can adjust the accurate volume, because the volume is determined through the pipe length x radius square x pi, and such structural error is less, and the adjustment is convenient.

An apparatus includes a first portion configured to attach to a target middle ear portion of a recipient's body. The apparatus also includes an elongated second portion that is rigidly fixed to and extends from the first portion. The second portion has an end portion configured to be rigidly secured to a transducer assembly having a longitudinal axis. The second portion extends from the transducer assembly at an angle greater than 30 degrees relative to the longitudinal axis. The first portion and the second portion are configured to respond to a first vibration displacement of the target middle ear portion by providing a second vibration displacement to the transducer assembly. The second vibration displacement is greater than the first vibration displacement.

This invention discloses a wearable ultrasound delivery device for treating otitis media, comprising a wearable main body with a flexible structure adapted to the shape of the patient's ear canal, and a through-hole central channel; an ultrasound drug delivery device, detachably disposed within the central channel, comprising a drug carrier for carrying the therapeutic drug to be delivered, an ultrasound transducer assembly for providing an ultrasound-guided drug delivery mode, and a handheld controller for adjusting the millimeter-level displacement of the drug carrier into the middle ear cavity; wherein, the ultrasound transducer assembly comprises a flexible substrate and multiple piezoelectric transducer units integrated on the flexible substrate, the multiple piezoelectric transducer units constituting a phased array transducer array. This device solves the technical problems of inaccurate drug delivery, low drug delivery efficiency, inability to adapt to the ear canal structure, and complex operation in the prior art.

The present application relates to the technical field of artificial implant medical device surface modification and middle ear hearing reconstruction, and discloses a processing method for enhancing the fixing stability of an artificial auditory ossicle prosthesis, the prosthesis and application. The method comprises the following steps: after the surface of the auditory ossicle prosthesis in contact with the middle ear tissue is cleaned, a polydopamine layer is formed in a basic dopamine solution, then gelatin, hyaluronic acid or cellulose sulfate is connected to the surface of the polydopamine layer through a carbodiimide activation system to form a viscous functional layer, and the dry sponge-like structure is obtained through freeze-drying. The functional layer can quickly rehydrate and restore the adhesion state after contacting with human blood or tissue fluid, thereby improving the fixing stability of the artificial auditory ossicle prosthesis in the initial implantation stage and reducing the risk of displacement or dislocation.

A device and method for treating a middle ear disorder in a patient includes providing to the patient an intraoral vibration device having a mouthpiece for contacting an oral cavity of the patient, wherein the intraoral vibration device has a frequency tuned to treat the middle ear disorder, and providing instructions for using the intraoral vibration device. The instructions provided for using the intraoral vibration device include placing the mouthpiece over at least one portion of the oral cavity, and applying a vibratory force at the frequency to treat the middle ear disorder.

An apparatus for detecting ear structure movements or changes, or changes in pressure in the ear-canal of a user, in order to control or affect the function of an associated device. The apparatus includes a sensor apparatus capable of being worn by the user to be located in or adjacent an ear-canal of the user. The sensor apparatus includes at least one sensor being located and configured to detect and capture sensor data relating to middle ear, ear-drum complex, ear-drum margin, and / or other ear structure movements or changes of characteristics, or changes in pressure in the ear-canal of the user. A device is provided for processing and analysing sensor data from the sensor apparatus. The device analyses sensor data concerning: eye movement or directional auditory attention or focus data, and / or voluntary control data.

The utility model relates to the technical field of scalpels, and discloses a middle ear muscle cutting knife assembly which comprises a knife body and a storage box used for storing the knife body, the knife body comprises a knife handle, a knife rod and a knife head, the knife handle and the knife rod are both of a cylindrical structure, an inclined connecting rod is arranged at the end of the knife handle, the connecting rod is connected with the knife rod, and the knife head is connected with the knife rod. The tool bit is arranged at the end, away from the tool handle, of the tool bar. The whole storage box is of a square structure, the interior of the storage box is hollow, the upper portion of the storage box is open, and a cover body is arranged at the opening in a sliding mode; a plurality of groups of limiting seats are arranged on the side wall of the storage box, and the cutter bars are clamped in the limiting seats; the cutting knife provided by the utility model is used for cutting two small middle ear muscles, and the inclined connecting rod is matched with the knife rod, so that the knife head can be in a middle ear tympanic chamber when the knife handle is held by a hand, and the use is convenient; and the storage box can be used for the cutter body, so that the cutter body can be well stored, and the cutter body is prevented from being influenced by the outside.

There is presented a hearing device for being placed at least partially in an ear canal. The hearing device includes a rechargeable battery, and at least two charging areas on the surface of the hearing device, the charging areas enabling recharging the rechargeable battery by applying a voltage from one charging area to another charging area. At least one charging area is positioned on the hearing device at the end of the hearing device facing into the middle ear during use and optionally out of contact with the walls of the ear canal during use.

The application discloses a tympanic ventilation tube with spiral locking, multiple waterproof and valve control drainage functions, and belongs to the field of ear implant medical devices. The ventilation tube comprises a tube body, an implant device interface is arranged at the outermost end of the tube body, a one-way duckbill valve is arranged at the end close to the external auditory canal, micro-flow ventilation holes are distributed in the circumferential direction of the side wall, a flexible sealing sheet is arranged on the outer side of the tube body, and a continuous single-ring gradually-changing asymmetric spiral fixing structure is arranged on the outer periphery of the middle ear cavity. The spiral fixing structure induces the radial flanging of the tympanic membrane tissue to be embedded between the spiral structure and the outer wall of the tube body to form axial locking through the asymmetric section, and realizes gradual release when reversely rotating through the rise angle, tooth height and round angle gradient; the sealing sheet realizes stable adhesion and controllable peeling through the thickness gradient, pre-stress and surface energy gradient; the micro-flow ventilation holes and the duckbill valve constitute a gas-liquid separation double channel, realize low-resistance ventilation, liquid blocking and pressure-driven drainage. The application can realize stable fixation, water-tight sealing, controllable ventilation, one-way drainage and low-damage implantation and removal.

An exemplary system and method are disclosed for the assessment of auditory sound conduction in the outer and middle ears in newborns and infants during the time of standard universal newborn hearing screening (UNHS) (inpatient and outpatient) in the first month of life using absorbance peak template (APT) analysis. Rather than using normative ranges showing the bounds of normal absorbance values at each frequency across frequencies, the exemplary system and method employ analysis of coherent morphological absorbance-frequency features, which are most diagnostically useful and theoretically informative, in the mid-frequency absorbance peak. The analysis can detect mid-frequency absorbance peaks in the absorbance peak template while also providing an overlay of the absorbance vs. frequency plot on the screen of the test instrument to determine key metrics in the parameters for normal absorbance peaks.

The invention relates to the technical field of nano medicines, and discloses an ATP / cerium coordination polymer nano regulator as well as a preparation method and application thereof. The invention relates to an ATP / cerium coordination polymer nano regulator. The invention relates to a self-assembly hydrogel which is prepared from raw materials including cerous nitrate (III), adenosine-5 '-disodium triphosphate, phospholipid polyethylene glycol amino, SS31 peptide and a diselenide cross-linking agent through a self-assembly and cross-linking method, can effectively remove ROS (reactive oxygen species) in an inner ear and protect cells from oxidative stress injury, thereby protecting auditory cells and improving the quality of the inner ear. The traditional Chinese medicine composition has the effect of treating hearing loss caused by oxidative stress induced by noise, can be used for treating hearing loss through middle ear cavity local administration, is simple in preparation method and mild in reaction condition, and can realize large-scale production. Cascade catalysis of cerium (III) and cerium (IV), ATP (adenosine triphosphate) energy supply and a nano system of a selenium biological material are utilized, and a novel method is provided for treating noise-induced hearing loss.

The present invention relates to an ear catheter for insertion into the Eustachian canal, comprising a catheter tube (2) with at least three lumens: a first lumen as an administration lumen (2a) for administering a drug, a second lumen as an inflation lumen (2b) for inflating a distally disposed inflatable balloon (17), and a third lumen as a pressure relief lumen (2c) for relieving pressure in the middle ear region. One-way valves (11, 12) are provided to prevent backflow of drug from the administration lumen (2a) and inflation fluid from the inflation lumen (2b), and a pressure limiting device (13) is provided to limit the pressure in the balloon.

This invention provides a biodegradable Eustachian tube support and a biodegradable Eustachian tube support system. The biodegradable Eustachian tube support includes a connected Eustachian tube receiving portion and a middle ear receiving portion. The Eustachian tube receiving portion, when in an expanded state without external force, is tubular and has a hollow, through-hole cavity. After implantation into the Eustachian tube, the Eustachian tube receiving portion is in the expanded state to open the Eustachian tube. The middle ear receiving portion includes a linear base structure. When not subjected to external force, the base structure itself forms a three-dimensional winding shape in space. After implantation into the tympanic cavity, the base structure forms the three-dimensional winding shape, filling the area of ​​the tympanic cavity adjacent to the Eustachian tube to maintain communication between the tympanic cavity and the Eustachian tube, while preventing the Eustachian tube receiving portion from sliding. Both the Eustachian tube receiving portion and the base structure are made of biodegradable materials.

The present invention relates to a middle ear inflammation treatment device. Disclosed is a middle ear inflammation treatment device installed with a ventilation tube, the device comprising: a handle; a cutting sheath connected to the handle and having a tubular shape with an inner diameter greater than an outer diameter of the ventilation tube, and wherein the ventilation tube is inserted into the cutting sheath; and a suction tube formed to be relatively movable to the cutting sheath in a length direction of the cutting sheath within the cutting sheath, wherein the suction tube has a tubular shape to suck and remove exudate in a middle ear through the suction tube; and a moving tool located outside the handle and relatively moving the suction tube to the cutting sheath.

The invention relates to the technical field of biomedical engineering. A middle ear fully-implanted artificial cochlea comprises a sensing part and a stimulating electrode part, and the sensing part is directly connected with the stimulating electrode part. The sensing part comprises a supporting layer, and the supporting layer is made of silicon or silicon dioxide; the sensing part further comprises piezoelectric units fixed on the supporting layer, and each piezoelectric unit comprises an upper electrode layer, a piezoelectric sensing layer made of a piezoelectric material and a lower electrode layer which are stacked in the thickness direction; the resonant frequencies of the piezoelectric units are different; the stimulating electrode part comprises platinum electrode contacts which are arranged in one-to-one correspondence with the piezoelectric units, and the platinum electrode contacts are connected with the piezoelectric units through platinum wires; the stimulating electrode part further comprises an insulating sleeve connected with the supporting layer, and the platinum electrode contacts are sequentially arranged in the length direction of the insulating sleeve. A signal processing circuit between a traditional sensing part and a stimulating electrode part is omitted, meanwhile, external power supply and an active circuit are not needed, and sound-electricity conversion is achieved purely depending on the piezoelectric effect.

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

Embodiments disclosed herein relate to an endoscopic device and a method to provide dynamic visualization of the middle ear. The endoscopic device includes a handle and a shaft extending therefrom. The shaft includes a rigid portion distal the handle and an articulating portion distal the rigid portion. The articulating portion is configured to articulate with respect to the rigid portion. The articulating portion includes an imaging sensor coupled thereto. The handle can include one or more actuators configured to cause the articulating portion to articulate.

The present invention relates to an ear catheter for insertion into the middle ear region through an incision in the tympanic membrane, comprising a catheter tube (2) having a distal end (d) and a proximal end (p), the catheter tube (2) comprising at least three lumens: a first lumen in the form of a dosing lumen (3), a second lumen in the form of an extension lumen (4), and a third lumen in the form of a pressure release lumen (5), the ear catheter (1) further comprising a first distal sealing element (6) and a second sealing element (7) arranged proximal to the first sealing element (6), the sealing elements (6, 7) forming a dosing region in the distal region of the catheter tube (2), at least the first sealing element (6) being in the form of an inflatable balloon connected in a fluid-permeable manner to the extension lumen (4). The ear catheter according to the present invention allows for the effective treatment of middle ear diseases.