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Composition for external use, application of composition for external use and therapeutic agent for external use

The technology of a composition for external use and a therapeutic agent is applied in the field of biomedicine and can solve the problems of affecting the mood and sleep of patients, lack of obvious therapeutic effect on skin dysfunction, distraction and the like

Inactive Publication Date: 2018-12-25
因之彩生物科技(武汉)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Cutaneous neurosis such as paresthesia, neurodermatitis, autumn dry dermatitis, etc., although not life-threatening, often lasts for half a year or several years, affecting the patient's mood or / and sleep, distracting attention, and affecting work efficiency etc., but most of the current external skin drugs can only be used for skin itching symptoms caused by external environmental factors, bacterial infections or physical lesions of patients. Skin dysfunction such as dermatitis has no obvious therapeutic effect

Method used

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  • Composition for external use, application of composition for external use and therapeutic agent for external use
  • Composition for external use, application of composition for external use and therapeutic agent for external use
  • Composition for external use, application of composition for external use and therapeutic agent for external use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of embodiment 1 external use ointment

[0041] (1) Weighing raw materials: rhEGF 0.005g, rhbFGF 0.005g, ointment body 5kg, wherein, the formula of the ointment body is shown in Table 1 below.

[0042] Table 1 Ointment formulation for external use

[0043]

[0044] (2) Preparation of external ointment: according to the formula in Table 1, add the raw materials for preparing the ointment body into a heating agitator, heat to 80°C, stir at a speed of 100rpm for 10min, then cool down, and wait for the temperature of the body to drop below 40°C , add rhEGF and rhbFGF to the stirrer, then stir at 40rpm for 5min to prepare external ointment, discharge and pack.

Embodiment 2

[0045] The preparation of embodiment 2 cream for external use

[0046] (1) Weighing of raw materials: rhEGF 0.005g, rhbFGF 0.005g, and 5kg of cream-like material. The formula of the cream-like material is shown in Table 2 below.

[0047] Table 2 Cream formulation for external use

[0048]

[0049] (2) Preparation of cream for external use: according to the formula in Table 2, add the raw materials for preparing the cream-like material into a heating mixer, heat to 80°C, stir at a speed of 100rpm for 10min, then cool down, and wait for the temperature of the material to drop to 40 Below ℃, add rhEGF and rhbFGF into the stirrer, and then stir at 40 rpm for 5 minutes to prepare a cream for external use, which is discharged and packaged.

Embodiment 3

[0050] The preparation of embodiment 3 external emulsions

[0051] (1) Weighing raw materials: rhEGF 0.004g, rhbFGF 0.004g, milky material body 5kg, wherein, the formula of the milky material body is shown in Table 3 below.

[0052] Table 3 Emulsion formula for external use

[0053]

[0054]

[0055] (2) Preparation of emulsion for external use: according to the formula in Table 3, add the raw materials for preparing the milky material body into a heating mixer, heat to 80°C, stir at a speed of 100rpm for 10min, then cool down, and wait for the temperature of the material body to drop below 40°C , add rhEGF and rhbFGF to the stirrer, and then stir at 40rpm for 5min to prepare an emulsion for external use, which is discharged and packaged.

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Abstract

The invention discloses a composition for external use, application of the composition for external use and a therapeutic agent for external use. The composition for external use comprises a recombinant human epidermal growth factor and a recombinant human basic fibroblast growth factor. By adoption of the recombinant human epidermal growth factor and the recombinant human basic fibroblast growthfactor to prepare the composition for external use, when the composition for external use is applied to a therapeutic agent for external use in treatment of dermatoneurosis, remarkable treatment effects on dermatoneurosis formication, neurodermatitis, autumn-dryness dermatitis and the like are achieved through combination of the recombinant human epidermal growth factor and the recombinant human basic fibroblast growth factor.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an external composition, its application and an external therapeutic agent. Background technique [0002] The skin of normal people is sensitive to temperature, touch, pressure, and pain caused by injury, which is caused by the nerve endings distributed in the skin feeling the stimulation and conducting it to the sensory center. Skin paresthesia refers to abnormal sensations that are not caused by external physical, chemical, biological and other factors, including pain, acupuncture, ants, heat without congestion, itching, etc., except for itching , The etiology and pathological mechanism of the first few feelings are still unknown. Previous knowledge believed that it was related to neurosis. Neurosis is a disease with abnormal nerve function and no organic changes in the nervous system have been found so far. Neurosis is manifested on the skin as skin crawling, itching (for...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P17/00A61P25/00
CPCA61K38/1808A61K38/1825A61P17/00A61P25/00A61K2300/00
Inventor 李乾
Owner 因之彩生物科技(武汉)有限公司
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