Method for detecting in-vivo direct acting component in periploca forrestii schltr medicinal material

A detection method and technology of Helicobacter sp., which is applied in the field of detection of directly acting components in the body of Helicobacter sp. Sensitive effect

Inactive Publication Date: 2018-12-28
GUIZHOU MEDICAL UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Although there are many literatures on the chemical constituents of S. sylvestris, the research on the effective material basis of S. sylvestris, especially the direct action substances in the body of S. sylvestris is still blank, which has affected the rational development and use of S. sylvestris.

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  • Method for detecting in-vivo direct acting component in periploca forrestii schltr medicinal material
  • Method for detecting in-vivo direct acting component in periploca forrestii schltr medicinal material
  • Method for detecting in-vivo direct acting component in periploca forrestii schltr medicinal material

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Embodiment Construction

[0020] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings. It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not constitute a conflict with each other. In the accompanying drawings, the main point is to observe the trend of the peaks of the lines. For some unclear words generated by the software in the figure, those skilled in the art can ignore them, which will not affect the understanding of the technical solution of the present invention.

[0021] 1. Materials

[0022] 1.1 Reagent

[0023] 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 3,4-O-dicaffeoylquinic acid3,5-O-dicaffeoylquinic acid, 4,5-O -Dicaffeoylquini...

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Abstract

The invention discloses a method for detecting the in-vivo direct acting component in a periploca forrestii schltr medicinal material. An UHPLC-Q-TOF-MS (Ultra-High Performance Liquid Chromatography-Quadrupole-Time Of Flight-Mass Spectrometry) technology is adopted; a serum fingerprint chromatogram and a blank rat serum fingerprint chromatogram are compared after a periploca forrestii schltr extractive and a rat oral periploca forrestii schltr extractive; the migration component in rat blood after the oral periploca forrestii schltr extractive is determined; the in-vivo direct acting componentin the periploca forrestii schltr medicinal material is definite; and thus, reference is provided for effect material basis that periploca forrestii schltr plays a pharmacological role and quality control.

Description

technical field [0001] The invention relates to the field of drug analysis, in particular to a method for detecting components directly acting in vivo in the medicinal material of Teng japonica. technical background [0002] The composition of traditional Chinese medicine is complex, and oral administration is the main method of traditional Chinese medicine treatment. Modern research has proved that after oral administration of traditional Chinese medicine, only the components absorbed into the blood (that is, migration components, including original components, metabolites and stress components produced by the body) , distributed to various tissues, organs or targets along with the systemic circulatory system, and the curative effect can only be produced when a certain blood concentration is reached. Therefore, through oral administration, the components that actually enter the blood may be the material basis of direct action in the body of traditional Chinese medicine. Onl...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 郑林黄勇李勇军巩仔鹏李月婷覃小丽杨畅孙佳陆苑刘亭
Owner GUIZHOU MEDICAL UNIV
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