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Gel tissue plugging material and its preparation method and plugging product

A plugging material and tissue technology, which is applied in the fields of surgery, surgical adhesives, medical science, etc., can solve the problems of poor adhesion, difficult to heal, and low bursting strength, and achieve excellent adhesion performance, easy molding, and high safety sexual effect

Active Publication Date: 2021-05-18
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the adhesion is poor, and it is easy to fall off from the wound; the temperature around the wound is raised to cause a burn wound, which is difficult to heal; the speed of hemostasis and the amount of hemostasis are still not enough for a large number of rapid bleeding Emergency treatment requirements; liquid leakage cannot be stopped quickly; bursting strength is low, etc.

Method used

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  • Gel tissue plugging material and its preparation method and plugging product

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Effect test

no. 1 approach

[0046]Such asfigure 1 As shown in the first embodiment of the present invention, a gel tissue blockage material includes: a base 1, the substrate 1 comprising a gel layer; and a wet adhesive present in at least one surface of the substrate 1 Layers 2, the wet adhesive layer 2 is contacted with the adhesion solution by at least one surface of the substrate 1, and the adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer. In the liquid.

[0047]The expansion strength of the gel tissue blockage material of the present invention is between 0.1 kPa-100 kPa, for example: 1 kPa-100 kPa, or 10 kPa-80 kPa, can also be 20 kPa-60 kPa, can also be 30 kPa-40 kPa; The fracture elongation of the gel tissue blockage material of the present invention is between 1% and 1500%, may be 10% -1200%, can also be 100% -1000%, can also be from 200% to 800%, Can be 400% -600%.

[0048]The gel tissue blockage material of the present invention has excellent tissu...

no. 2 approach

[0074]In a second embodiment of the present invention, a method of preparing a gel tissue sealing material comprising the step of composite forming a matrix with a wet adhesion layer, wherein

[0075]The substrate includes a gel layer;

[0076]The wet adhesive layer is obtained by contacting the adhesion solution by at least one surface of the substrate;

[0077]The adhesion solution contains an amino compound and a buffer, the amino compound being dissolved in the buffer.

[0078]In the present invention, the substrate may be a pre-prepared matrix molded formation formation.

[0079]In the present invention, the method of preparing the substrate comprises crosslinking the base solution. The solute of the substrate solution comprises one or two or more combinations of a polymer polymer or a derivative thereof. Preferably, the solute of the substrate solution comprises sodium alginate and / or polyacrylamide. More preferably, the solute of the substrate solution includes sodium alginate and polyacr...

no. 3 approach

[0091]In a third embodiment of the present invention, a blocking article is provided comprising a gel tissue blockage material according to the first embodiment, or a condensation obtained according to a preparation method of a gel tissue material according to a second embodiment. Glue tissue blockage material.

[0092]In the blocking article of the present invention, optionally, a backing layer has a backing layer on one side of the matrix without a wet adhesive layer, and has a peelable layer on the wet adhesive layer. The present invention does not specifically limit the material of the backing layer and the peelable layer, and does not affect the function of the blocking article of the present application.

[0093]The sealing article of the present invention can be used in tissue osmaste, capillary hemorrhage, hemostasis, and / or hemostasis, and / or hemostasis for burns, trauma, surgical wound, etc., has broad application prospect. The sealing article of the present invention can al...

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Abstract

The invention provides a gel tissue plugging material, a preparation method thereof and a plugging product. The gel tissue plugging material includes: a base body, the base body includes a gel layer; and a wet-state adhesive layer existing on at least one surface of the base body, and the wet-state adhesion layer passes through at least one surface of the base body and This is obtained by contacting an adhesion solution containing an amino compound and a buffer in which the amino compound is dissolved. The gel tissue plugging material of the present invention has excellent adhesion performance, bursting strength and suitable elongation at break, and also has good elasticity, and can be effectively bonded to the surface of a living body or a substantial organ, thereby Act as tissue sealant.

Description

Technical field[0001]The present invention relates to a gel tissue sealing material and a preparation method thereof and a blocking article, belonging to the field of medical implantation materials.Background technique[0002]Tissue blocking, such as hemostasis blocking, tissue liquid leakage blocker, etc. It is an important part of the hospital's departmental surgery, which plays a considerable role in the success of surgery and the safety of patients. Effective hemostasis is the key to mitigating patient suffering, reducing mortality, and rapid and effective hemostasis becomes a focus on this issue. It is inevitable that all kinds of sudden accidents will be encountered in everyday life, and the disaster is damaged.[0003]At present, common hemostatic materials have micro-hole inorganic materials (zeolites), multi-pore starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostasis, alpha-cyanoacrylate tissue glue, etc. Although there is a good hemostatic effect, there...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/04A61L24/10A61L24/00A61B17/12
CPCA61B17/12181A61L24/001A61L24/0015A61L24/0031A61L24/046A61L24/06A61L24/08A61L24/104C08L5/04C08L33/26C08L5/08C08L79/02
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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