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Preparation method of in vitro diagnosis test paper strip based on CdSe quantum dots as marker

An in vitro diagnostic and quantum dot technology, applied in disease diagnosis, biological testing, nanotechnology for materials and surface science, etc., can solve problems such as difficult to diagnose accurately

Inactive Publication Date: 2019-01-01
北京盛坤康如医疗器械有限责任公司
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Problems solved by technology

However, enzyme activity assays have various drawbacks that make accurate diagnosis difficult

Method used

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  • Preparation method of in vitro diagnosis test paper strip based on CdSe quantum dots as marker
  • Preparation method of in vitro diagnosis test paper strip based on CdSe quantum dots as marker
  • Preparation method of in vitro diagnosis test paper strip based on CdSe quantum dots as marker

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Embodiment Construction

[0019] 1. If figure 1 , figure 2 shown, where figure 1 SEM images of CdSe quantum dots are shown, figure 2 A TEM image of CdSe quantum dots is shown. The preparation of CdSe quantum dots includes the following steps:

[0020] (1) Dissolve the copper source and indium source in the sulfur source, heat to 120°C under the protection of nitrogen, keep it warm until the solid particles are completely dissolved, and obtain the copper indium precursor; continue to heat up to 220°C and keep it warm for 10-25 minutes, Obtain CdSe quantum dot solutions with different particle sizes and fluorescence characteristics;

[0021] (2) After the CdSe quantum dot solution obtained in step (1) is centrifuged and purified to obtain CdSe quantum dots, after dispersing the obtained CdSe quantum dots in octadecene, heat to 230°C, and add zinc and Sulfur precursor liquid, then heat preservation reaction for 30 minutes, and the obtained CdSe / ZnS core-shell structure quantum dot solution is coole...

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Abstract

The invention relates to a preparation method of an in vitro diagnosis test paper strip based on CdSe quantum dots as a marker, and belongs to the field of biotechnology, wherein the preparation method comprises: preparation of CdSe quantum dots, coupling of quantum dots and primary antibody, and preparation of myocardial in vitro diagnosis test paper strip. According to the present invention, with the preparation method of the in vitro diagnosis test paper strip, the contents of troponin I, myoglobin and creatine kinase isoenzyme in whole blood, serum and plasma can be quickly and quantitatively detected so as to provide the basis for the early stage diagnosis of myocardial diseases; and the preparation method has advantages of simple operation, high efficiency, low cost, easy automationand the like.

Description

technical field [0001] The invention relates to a preparation method of an in vitro diagnostic test strip based on CdSe quantum dots as markers, belonging to the field of biotechnology. Background technique [0002] Cardiovascular diseases such as acute myocardial injury, chronic heart failure and atherosclerosis are common diseases that seriously endanger human health. Heart failure is the terminal stage of various heart diseases. With the aging population and the increase in the incidence of cardiovascular diseases in my country, the incidence of heart failure has a tendency to increase significantly. Since the 1950s, the dynamic determination of the activities of some metabolic enzymes has been the gold standard for the diagnosis of acute myocardial infarction (AMI). However, enzyme activity assays have various drawbacks that make accurate diagnosis difficult. [0003] Since the morbidity and mortality of heart failure are extremely high and have been on the rise in rec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/58C01B19/04C01G9/08B82Y30/00B82Y40/00
CPCG01N33/588B82Y30/00B82Y40/00C01B19/007C01G9/08C01P2004/80C01P2004/03C01P2002/01G01N2800/325
Inventor 刘宏飞
Owner 北京盛坤康如医疗器械有限责任公司
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