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Composite sound sensitizer and preparation method, application, use method and pharmaceutical composition thereof

A technology of compound sound and sonosensitizer, applied in the medical field, can solve the problems of low bioavailability and low tumor enrichment, and achieve the effect of improving the hypoxic microenvironment, improving the effect, accurate diagnosis and efficient treatment

Active Publication Date: 2019-01-04
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the defects of phototoxicity, low bioavailability, and low tumor enrichment of organic sonosensitizers, it is difficult for organic sonosensitizers to be widely used in sonodynamic therapy.

Method used

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  • Composite sound sensitizer and preparation method, application, use method and pharmaceutical composition thereof
  • Composite sound sensitizer and preparation method, application, use method and pharmaceutical composition thereof
  • Composite sound sensitizer and preparation method, application, use method and pharmaceutical composition thereof

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preparation example Construction

[0060] The present invention also provides a preparation method of a composite sound sensitizer, which comprises the following steps,

[0061] providing a matrix, dispersing the matrix in a first solvent to obtain a first mixed solution, the matrix being manganese dioxide;

[0062] providing an organic sonosensitizer, dissolving the organic sonosensitizer in a second solvent to obtain a second mixed solution;

[0063] under magnetic stirring, adding the second mixed solution to the first mixed solution to obtain a third mixed solution, and stirring the third mixed solution;

[0064] Stirring and centrifuging the third mixed solution to obtain the composite sound sensitizer, the composite sound sensitizer includes a matrix and an organic sound sensitizer loaded on the matrix.

[0065] Preferably, after the third mixed solution is obtained, before the third mixed solution is stirred and centrifuged, water may be added to the third mixed solution, and the third mixed solution ad...

Embodiment 1

[0101] 1. Preparation of composite sound sensitizer

[0102] 1. The preparation of the matrix includes the following steps:

[0103] (1) 20mL of mixed aqueous solution containing hydrogen peroxide and tetramethylammonium hydroxide is provided, in the mixed aqueous solution, the mass percentage content of hydrogen peroxide is 3, and the content of described tetramethylammonium hydroxide is 0.6mol / L;

[0104] (2) At room temperature, a manganese dichloride aqueous solution with a volume of 10 mL and a molar volume of 0.3 mol / L is added dropwise to the mixed aqueous solution, the color of the solution immediately turns dark brown, and vigorously stirred for 8 hours to form a matrix primary body;

[0105] (3) centrifuging the matrix body at a speed of 2000rpm for 20 minutes;

[0106] (4) Carry out purification treatment to the matrix precursor with water and ethanol respectively;

[0107] (5) Disperse the purified matrix in water, and use an ultrasonic cell pulverizer to soni...

Embodiment 2

[0122] 1. Preparation of composite sound sensitizer

[0123] 1. The preparation of the matrix includes the following steps:

[0124] (1) 15mL of mixed aqueous solution containing hydrogen peroxide and tetramethylammonium hydroxide is provided, in the mixed aqueous solution, the mass percentage content of hydrogen peroxide is 1, and the content of described tetramethylammonium hydroxide is 0.4mol / L;

[0125] (2) At room temperature, a manganese dichloride aqueous solution with a volume of 5 mL and a molar volume of 0.1 mol / L is added dropwise to the mixed aqueous solution, the color of the solution immediately turns dark brown, and vigorously stirred for 10 hours to form a matrix primary body;

[0126] (3) centrifuging the base body at a speed of 1000 rpm for 10 minutes;

[0127] (4) Carry out purification treatment to the matrix precursor with water and ethanol respectively;

[0128] (5) Disperse the purified matrix in water, and use an ultrasonic cell pulverizer to sonic...

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Abstract

The invention provides a composite sound sensitizer. The composite sound sensitizer includes a matrix and an organic sound sensitizer body loaded on the matrix, and the matrix refers to manganese dioxide. The invention further provides a preparation method of the composite sound sensitizer. The composite sound sensitizer has the advantages of low phototoxicity, high bioavailability, high tumor enrichment and the like.

Description

technical field [0001] The present invention relates to the field of medical technology, in particular to a compound sound sensitizer, a preparation method of the compound sound sensitizer, an application of the compound sound sensitizer, a method of using the compound sound sensitizer, and the use of the compound sound sensitizer in the preparation of medicines The use of and the pharmaceutical composition comprising the composite sound sensitizer. Background technique [0002] Sonodynamic therapy is a new tumor treatment method that uses the strong penetrating ability of ultrasound to biological tissues to make organic sonosensitizers accumulated in deep tumors produce anti-tumor effects. It has the advantages of deep treatment, non-invasive, targeted and safe. However, due to the defects of phototoxicity, low bioavailability, and low tumor enrichment of organic sonosensitizers, it is difficult for organic sonosensitizers to be widely used in sonodynamic therapy. Content...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/32A61K31/409A61K47/02A61K49/06A61P35/00
CPCA61K31/409A61K33/32A61K41/0033A61K47/02A61K49/06A61K2300/00
Inventor 蔡林涛梁锐晶韩志群郑明彬
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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