Gold nanostar @ gold-silver alloy Raman base material with high activity and preparation method thereof

A Raman substrate, silver alloy technology, applied in the field of nanomaterials, can solve the problems of poor specificity, inability to achieve quantitative detection, false positives, etc., and achieve the effects of easy control, green reagents, and simple operation.

Inactive Publication Date: 2019-01-04
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology

Since there are many factors that cause nanoparticle aggregation (such as ionic strength, temperature, pH, etc.), the method of using random nanoparticle aggregation to enhance the Raman signal is greatly affected by external factors, has poor specificity, and often produces false positives. Quantitative detection cannot be achieved

Method used

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  • Gold nanostar @ gold-silver alloy Raman base material with high activity and preparation method thereof
  • Gold nanostar @ gold-silver alloy Raman base material with high activity and preparation method thereof
  • Gold nanostar @ gold-silver alloy Raman base material with high activity and preparation method thereof

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Experimental program
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Embodiment 1～3

[0041] The preparation method of embodiment 1~3

[0042] (1) Raman beacon molecules modified on the surface of Venus nanoparticles

[0043] Take the prepared Venus nanoparticle solution, quickly add 4-ATP solution to it, stir and react overnight at 25°C, centrifuge at 8000 rpm for 10 minutes, remove the supernatant, add ultrapure water to resuspend, and prepare Raman Venus nanoparticles solution labeled with beacon molecules.

[0044] (2) Preparation of Venus@Silver Nanoparticles

[0045] Take the Raman beacon molecule-labeled Venus nanoparticle solution prepared in step (1), add the polyvinylpyrrolidone solution, phosphate buffer solution, and ascorbic acid solution described in the table below to it, mix well, and then adjust the pH with lye At about 9, add silver nitrate quickly at the end, stir and react at room temperature for 30 minutes in the dark, then centrifuge at 8000 rpm for 10 minutes, remove the supernatant, add ultrapure water to resuspend, and prepare Venus l...

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Abstract

The present invention discloses a gold nanostar @ gold-silver alloy nanometer base material with high Raman activity and a preparation method thereof and belongs to the technical field of nanometer materials. The method is characterized in that gold nanostar particles are used as cores to prepare gold nanostar @ silver core shell nanoparticles through reduction of silver nitrate on surfaces, and agold nanostar @ gold-silver alloy nanometer material with a tiny narrow slit structure is prepared by reducing chloroauric acid on the surfaces of gold nanostar @ silver and by utilizing the replacement and migration rule of gold and silver atoms and used as a Raman base material. The material of the present invention has the following advantages: 1) a strong hot spot region can be formed by thetiny narrow slit structure of gold nanostar @ gold-silver alloy nanoparticles, thereby greatly enhancing Raman signals of beacon molecules in this region; 2) gold nanostar @ gold-silver alloy nanoparticles are stable in Raman enhancement effect and good in reproducibility, thereby preventing loss of Raman signals of beacon molecules; and 3) the nano material can be used as a Raman label and used for quickly detecting harmful substances in food and environment with high sensitivity in combination with biomolecules such as antibodies and aptamers.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a highly active Venus@gold-silver alloy Raman base material and a preparation method thereof. Background technique [0002] Raman spectrum is a kind of scattering spectrum. When light is scattered from an atom or molecule, most of the photons are elastically scattered, which belongs to Rayleigh scattering. However, for a small fraction of scattered photons (about one in 10 million), the scattered frequency is usually lower than that of the incident photon, because of the energy exchange between the incident photon and the medium molecule, that is, for Raman scattering. Raman spectroscopy is based on the Raman scattering effect discovered by Indian scientist C.V. Raman (Raman). It analyzes the scattering spectrum different from the frequency of the incident light to obtain molecular vibration and rotation information, and is applied to the study of molecular st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02B22F9/24C22C5/02G01N21/65B82Y30/00B82Y40/00
CPCG01N21/658C22C5/02B82Y30/00B82Y40/00B22F9/24B22F1/07B22F1/054B22F1/17
Inventor 严文静戈永慧王红霞李艾潼李芮
Owner NANJING AGRICULTURAL UNIVERSITY
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