Image reconstruction method for X-ray photodynamic therapy

Abstract

The invention relates to an image reconstruction method for X-ray photodynamic therapy, comprising: 1, setting exposure parameters of a digital radiation imaging system and calibrating an imaging optical path so that an X-ray source, an object to be imaged, a grating and a CMOS flat panel detector are on the same straight line; 2, imaging a two-dimensional absorption grating to obtain an image contain only light intensity gradient information; 3, obtaining scintillating nanoparticles-photosensitizer complex, and then injecting the photosensitizer complex into the tissue to be tested; the tissue to be measured being put into the imaging cavity and irradiated from a plurality of projection angles to obtain an image containing light intensity gradient and tissue phase information; 4, according to the principle that the position of each pixel in the raster / tissue volume image received by the detector is shifted relative to the original raster projection image, the phase information of thetissue volume being calculated; 5, obtaining the three-dimensional structure information of the tissue body; 6, constructing an XLCT forward model; 7, obtaining spatial density distribution of scintillating nanoparticles-photosensitizer complexes.

Description

technical field [0001] The invention belongs to the fields of biomedical engineering and medical imaging, and relates to an image reconstruction method. Background technique [0002] Photodynamic therapy (PDT) is a treatment that uses light, photosensitizers, and oxygen molecules to kill target cells through cytotoxin (singlet oxygen) produced by photodynamic reactions. PDT has the advantage of selectively killing target cells, and has a good killing effect on recurrent and drug-resistant cancers in tumor treatment. It is considered to be the fourth clinical treatment method for cancer besides surgery, radiotherapy, and chemotherapy. PDT began to be applied to the treatment of human tumors in the 1970s, and my country began clinical research on photodynamic therapy of tumors in 1980, and has become the country with the largest number of PDT tumor types and cases today. [0003] However, the treatment depth of traditional PDT depends on the wavelength of excitation light, wh...

AI Technical Summary

Problems solved by technology

In recent years, scholars at home and abroad have verified the feasibility of XE-PDT through in vitro cell experiments, but so far, there is still a long distance from XE-PDT to clinical application. The time / space information of the state lacks effective monitoring, and imaging guidance such as XCT and magnetic resonance is only suitable for preoperative use, that is, there is a lack of effective in-vivo real-time guidance technology

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