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Nasal cavity allergen blocking agent, preparation method thereof and application thereof

An allergen and blocking agent technology, applied in the field of medicine, can solve problems such as rhinitis recurrence, achieve good blocking effect, uniform distribution, and repair the function of the ciliary system.

Inactive Publication Date: 2019-01-11
李同信 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once the patient stops using the drug and the isolation layer disappears, the antigenic substance will re-enter the nasal mucosa, which can easily cause recurrence of rhinitis

Method used

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  • Nasal cavity allergen blocking agent, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of boiled chicken egg yolk: Boil the egg for 10 minutes, let it cool and separate it.

[0037] Preparation of Magnolia Magnolia Extract: Obtained by crushing Magnolia Magnolia and extracting it with supercritical carbon dioxide. The extraction pressure is 20MPa, the extraction temperature is 50°C, the extraction time is 90min, and the carbon dioxide flow rate is 15L / h.

[0038] Preparation of Artemisia argyi leaf extract: Obtained by supercritical carbon dioxide extraction after pulverization of Artemisia argyi leaves. The extraction pressure is 20MPa, the extraction temperature is 45°C, the extraction time is 90min, and the carbon dioxide flow rate is 15L / h.

[0039] Preparation of Fangfeng Extract: It is obtained by crushing Fangfeng and extracting it with supercritical carbon dioxide. The extraction pressure is 30MPa, the extraction temperature is 45°C, the extraction time is 120min, and the flow rate of carbon dioxide is 15L / h.

[0040]Preparation of Ang...

Embodiment 2

[0045] Preparation of boiled chicken egg yolk: Boil the egg for 10 minutes, let it cool and separate it.

[0046] Preparation of Magnolia Magnolia Extract: Obtained by crushing Magnolia Magnolia and extracting it with supercritical carbon dioxide. The extraction pressure is 19MPa, the extraction temperature is 51°C, the extraction time is 80min, and the carbon dioxide flow rate is 15L / h.

[0047] Preparation of Artemisia argyi leaf extract: It is obtained by crushing Artemisia argyi leaves and extracting them with supercritical carbon dioxide. The extraction pressure is 21MPa, the extraction temperature is 44°C, the extraction time is 100min, and the carbon dioxide flow rate is 15L / h.

[0048] Preparation of Fangfeng Extract: It is obtained by crushing Fangfeng and extracting it with supercritical carbon dioxide. The extraction pressure is 29MPa, the extraction temperature is 46°C, the extraction time is 110min, and the flow rate of carbon dioxide is 15L / h.

[0049] Preparatio...

Embodiment 3

[0053] Preparation of boiled chicken egg yolk: Boil the egg for 10 minutes, let it cool and separate it.

[0054] Preparation of Magnolia Magnolia Extract: Obtained by crushing Magnolia Magnolia and extracting it with supercritical carbon dioxide, the extraction pressure is 21MPa, the extraction temperature is 49°C, the extraction time is 100min, and the carbon dioxide flow rate is 15L / h.

[0055] Preparation of Artemisia argyi leaf extract: Obtained by supercritical carbon dioxide extraction after pulverization of Artemisia argyi leaves. The extraction pressure is 19MPa, the extraction temperature is 46°C, the extraction time is 80min, and the carbon dioxide flow rate is 15L / h.

[0056] Preparation of Fangfeng Extract: It is obtained by crushing Fangfeng and extracting it with supercritical carbon dioxide. The extraction pressure is 31MPa, the extraction temperature is 44°C, the extraction time is 130min, and the flow rate of carbon dioxide is 15L / h.

[0057] Preparation of A...

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Abstract

The invention relates to a nasal cavity allergen blocking agent, a preparation method thereof and an application thereof. The blocking agent is prepared from cooked chicken egg yolk, sesame oil, beeswax, flos Magnoliae extract, folium Artemisiae Argyi extract, radix Saposhnikoviae extract, radix Angelicae Dahuricae extract, radix Cynanchi Paniculati extract and herba Menthae extract through extracting chicken egg yolk oil with sesame oil, mixing, and making into nasal cavity allergen barry agent. The application of the nasal cavity allergen blocking agent is in the treatment of allergic rhinitis, chronic rhinitis, acute rhinitis and diaper dermatitis, infantile eczema. The nasal cavity allergen blocking agent provided by the invention is applied on the nasal mucosa to form an isolation layer, which can not only block the antigen substance from entering the nasal mucosa, but also repair the function of the nasal cavity mucosa cilia system so as to achieve the goal of eradicating rhinitis.

Description

technical field [0001] The invention relates to the field of medicine, more specifically, it relates to a nasal cavity allergen blocking agent and its preparation method and application. Background technique [0002] Various types of rhinitis (rhinitis) have relatively few clinical characteristic symptoms, lack of objective clinical evaluation methods, and difficult etiology exploration, so it is difficult to strictly distinguish them. In general, rhinopathy can be divided into four categories: allergic rhinitis, nonallergic rhinitis, infectious rhinitis, and structural or mechanical rhinitis. [0003] Allergic rhinitis (allergicrhinitis, AR) is an IgE-mediated nasal mucosal inflammatory disease triggered by allergens (allergens) acting on atopic individuals. Clinically, it can be divided into 4 types, namely, mild intermittent, moderate to severe intermediate, mild persistent, and moderate to severe persistent. Although allergic rhinitis is not life-threatening, symptoms ...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/70A61K47/44A61P11/02A61P17/00A61P37/08A61K35/57A61K35/644
CPCA61K9/0043A61K9/7007A61K35/57A61K35/644A61K36/232A61K36/238A61K36/27A61K36/282A61K36/534A61K36/575A61K47/44A61P11/02A61P17/00A61P37/08A61K2300/00
Inventor 李同信邵猛
Owner 李同信
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