Use of zanthoxylum leaf total flavonoids extract

A technology of total flavonoids and pepper leaves, applied in the field of total flavonoids extracts from pepper leaves, can solve the problems of insufficient development and utilization, waste of resources, etc., and achieve the effects of promoting regional economic development, improving learning and memory, and increasing utilization value

Active Publication Date: 2019-01-11
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a by-product of Zanthoxylum bungeanum, Zanthoxylum bungeanum leaf resources are abundant, but the degree of development and utilization is insufficient, resulting in waste of resources

Method used

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  • Use of zanthoxylum leaf total flavonoids extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] First prepare the total flavonoids extract of Zanthoxylum bungeanum leaves according to the following steps:

[0025] (1) Wash the pepper leaves, dry them in the shade, and then crush them to a fineness of 0.1mm;

[0026] (2) Heat and reflux the pulverized Zanthoxylum bungeanum leaves with water for extraction at a heating temperature of 100°C, extract 3 times, each extraction takes 2.0 hours, the mass ratio of Zanthoxylum bungeanum leaves and water is 1:10, filter after extraction, and combine the filtrates, Then concentrate to obtain the crude extract A of total flavonoids;

[0027] (3) Fully dissolve the crude extract of total flavonoids from Zanthoxylum bungeanum leaves in water, and pass through D-101 macroporous adsorption resin column. Add water and crude extract to the column respectively, let it stand for adsorption for 24 hours, and then use 3.5 times BV of pure water, 30% methanol, 60% methanol, 85% methanol and methanol to elute in sequence. Concentrate to...

Embodiment 2

[0031] First prepare the total flavonoids extract of Zanthoxylum bungeanum leaves according to the following steps:

[0032] (1) Wash the pepper leaves, dry them in the shade, and then grind them to a fineness of 0.2 mm;

[0033] (2) The pulverized Zanthoxylum bungeanum leaves are extracted by cold soaking at room temperature with a mixed solution of methanol / water with an extraction solvent volume percentage of 80%, and the pulverized Zanthoxylum bungeanum leaves are soaked in the extraction solvent for 7 days, and the Zanthoxylum bungeanum leaves and the volume percentage The mass ratio of the mixed solution of 80% methanol / water is 1:5, extracting 3 times, filtering after extraction, merging the filtrate, and then concentrating to obtain the crude extract A of total flavonoids;

[0034] (3) According to the operation of step (3) in Example 1, extracts A (pure water), B (30% methanol), C (60% methanol), D (85% methanol) and E (methanol) were obtained ;

[0035] (4) Sodium ...

Embodiment 3

[0038] First prepare the total flavonoids extract of Zanthoxylum bungeanum leaves according to the following steps:

[0039] (1) Wash the prickly ash leaves, dry them in the shade, and then grind them to a fineness of 0.3 mm;

[0040] (2) The pulverized Zanthoxylum bungeanum leaves are subjected to percolation extraction with a mixed solution of ethanol / water with an extraction solvent volume percentage of 80%. Soak in the solution for 20 h, then carry out leakage extraction, the mass ratio of the pepper leaves and the mixed solution of 75% ethanol / water by volume percentage is 1:15, after extraction, filter, combine the filtrate, and then concentrate to obtain the total flavonoids crude Extract A;

[0041] (3) According to the operation of step (3) in Example 1, extracts A (pure water), B (30% methanol), C (60% methanol), D (85% methanol) and E (methanol) were obtained ;

[0042] (4) Sodium nitrite-aluminum nitrate method was used to determine the content of total flavonoi...

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Abstract

The invention discloses the use of zanthoxylum leaf total flavonoids extract, which can improve the learning and memory of transgenic Alzheimer disease model of drosophila melanogaster, and has good effect in medicines for treating Alzheimer's disease.

Description

technical field [0001] The present invention specifically relates to the use of a total flavonoid extract from Zanthoxylum bungeanum leaves. Background technique [0002] Zanthoxylum bungeanum is Rutaceae Zanthoxylum bungeanum ( Zanthoxylum bungeanum ) of dry mature leaves. "Compendium of Materia Medica" records that "Prickly ash leaves are pungent, non-toxic, hot, and can cure cold accumulation, scabies, beriberi, antiseptic, sterilization, cholera tendons, paint sores, insecticide, etc." Zanthoxylum bungeanum is widely used in daily life. As a by-product of Zanthoxylum bungeanum, Zanthoxylum bungeanum leaf resources are abundant, but the degree of development and utilization is insufficient, resulting in waste of resources. It is an important measure of the national strategy of "targeted poverty alleviation" to develop and utilize pepper leaf resources to enhance its use value in the fields of pharmaceuticals, health products, functional foods, food additives, cosmetics...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P25/28A61K127/00
CPCA61K36/758A61P25/28
Inventor 杨军丽孟宪华师彦平
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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