Unlock instant, AI-driven research and patent intelligence for your innovation.

Synthesis method of 2-indanone

A synthesis method and technology of indanone, which is applied in the field of synthesis of 2-indanone, can solve the problems of poor reactivity, strong corrosion of formic acid, low purification efficiency, etc., and achieve the effect of improving the reaction yield

Inactive Publication Date:
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] 2-Indanone (2-Indanone) CAS: 615-13-4 is an important intermediate in organic synthesis, widely used in the synthesis of medicines, pesticides, dyes, etc., and also in the synthesis of organic light-emitting materials and dyes application, it can also be used as an organic protecting group that can be removed by light; the existing synthetic methods generally use 88% formic acid as the reaction solvent, formic acid is highly corrosive, and the formic acid recovered after the reaction decreases, and then the content of formic acid is increased as the reaction solvent to continue use, the cost is relatively high, therefore, formic acid cannot be recycled as a reaction solvent
The existing 2-indanone purification method is steam distillation, the purification efficiency of this purification method is relatively low, and pure hydrogen peroxide is used for oxidation, the reactivity is relatively poor, and the yield is not ideal, aiming at the problems existing in the existing synthesis method , Exploring a new synthetic process for bioactive synthetic raw material 2-indanone has a good industrial application prospect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind of synthetic method of intermediate 2-indanone, it is characterized in that the method comprises the following steps:

[0020] Step 1, 45ml glacial acetic acid, 27ml hydrogen peroxide and 3g of AlCl 3 / SBA-15 supported catalyst was added to a 250ml three-necked bottle, and stirred evenly at 50°C;

[0021] Step 2. Slowly add 120ml of acetic anhydride and 30ml of indene dropwise under heat preservation conditions, keep the reaction temperature not exceeding 55°C, complete the dropwise addition within 2h, and react at 40°C for 12h;

[0022] Step 3. The solvent and water after the reaction were evaporated under reduced pressure, and the remaining liquid was cooled to -15°C for 2 hours, the precipitated product was filtered with suction, washed twice with distilled water, and vacuum-dried at 60°C for 8 hours to obtain a white primary product;

[0023] Step 4. Take 10g of the initial product and add it to a 250ml round-bottomed flask, add 50ml of 10% dilute sulfuric a...

Embodiment 2

[0032] Step 2. Slowly add 100ml of acetic anhydride and 30ml of indene dropwise under heat preservation conditions, keep the reaction temperature not exceeding 55°C, complete the dropwise addition within 2h, and react at 40°C for 12h; the rest of the steps are the same as in Example 1.

Embodiment 3

[0034] Step 2. Slowly add 80ml of acetic anhydride and 30ml of indene dropwise under heat preservation conditions, keep the reaction temperature not exceeding 55°C, complete the dropwise addition within 2h, and react at 40°C for 12h; the rest of the steps are the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a synthesis method of 2-indanone. Glacial acetic acid, hydrogen peroxide, acetic anhydride, indene and ethyl orthosilicate are used as major raw materials. The synthesis process has the advantages that under the effect of a loaded AlCl3 / SBA-15 catalyst, 1,2-indene diol generated by oxidation reaction of the acetic anhydride and the indene is subjected to sulfuric acid acidification; sublimation purification is performed to obtain a high-purity 2-indanone intermediate. In the preparation process, no waste liquid or waste gas is generated; steamed acetic acid can be continuously brought into operation; the product yield is improved; meanwhile, the green production environment-protection requirements are achieved.

Description

technical field [0001] The invention relates to a method for synthesizing 2-indanone, which belongs to the field of chemical synthesis. Background technique [0002] 2-Indanone (2-Indanone) CAS: 615-13-4 is an important intermediate in organic synthesis, widely used in the synthesis of medicines, pesticides, dyes, etc., and also in the synthesis of organic light-emitting materials and dyes application, it can also be used as an organic protecting group that can be removed by light; the existing synthetic methods generally use 88% formic acid as the reaction solvent, formic acid is highly corrosive, and the formic acid recovered after the reaction decreases, and then the content of formic acid is increased as the reaction solvent to continue use, the cost is relatively high, therefore, formic acid cannot be recycled as a reaction solvent. The existing 2-indanone purification method is steam distillation, the purification efficiency of this purification method is relatively l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/52C07C45/81C07C49/67C07C29/48C07C35/32B01J29/03
CPCB01J29/0308C07C29/48C07C45/52C07C45/81C07C2602/08C07C49/67C07C35/32
Inventor 张永伟