Fluorine-containing thiocarbamate compound and synthesizing method thereof
A technology for fluorine-containing thiocarbamate and ester compounds, applied in the direction of organic chemistry and the like, can solve the problems of few reports on the synthesis of thiothiocarbamate, achieve good industrial application prospects, high selectivity and yield Effect
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[0029] Example 1
[0030] Synthesis of O-(1,1,1,3,3,3-hexafluoropropan-2-yl)(3-oxopentan-2-yl)(phenyl)aminothiocarbamate
[0031] Add 1.0mmol of 3-oxopentan-2-yl 4-methylbenzenesulfonate, 1.2mmol of phenylthioisocyanate, 1.5mmol of triethylamine into the reaction vessel, and then add 2mL of hexafluoroisopropyl Alcohol is reacted at room temperature. After the reaction, it is washed with an aqueous solution, then extracted with an organic solvent, dried, and concentrated under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the target product with a yield of 89%.
Example Embodiment
[0032] Example 2
[0033] Synthesis of O-(1,1,1,3,3,3-hexafluoroprop-2-yl)(5-oxonan-4-yl)(phenyl)aminothiocarbamate
[0034] Add 1.0mmol of 5-oxononan-4-yl 4-methylbenzenesulfonate, 1.2mmol of phenylthioisocyanate, 1.5mmol of triethylamine into the reaction vessel, and then add 2mL of hexafluoroisopropyl Alcohol is reacted at room temperature. After the reaction, it is washed with an aqueous solution, then extracted with an organic solvent, dried, and concentrated under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the target product with a yield of 85%.
Example Embodiment
[0035] Example 3
[0036] Synthesis of O-(1,1,1,3,3,3-hexafluoroprop-2-yl)(6-oxoundecyl-5-yl)(phenyl)aminothiocarbamate
[0037] Add 1.0mmol of 6-oxoundecyl-5-yl 4-methylbenzenesulfonate, 1.2mmol of phenylthioisocyanate, 1.5mmol of triethylamine into the reaction vessel, and then add 2mL of hexafluoroisocyanate Propanol is reacted at room temperature. After the reaction is completed, it is washed with an aqueous solution, then extracted with an organic solvent, dried, and evaporated under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the target product with a yield of 88%.
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