Animal fixing device and applications thereof

Abstract

The invention discloses an animal fixing device. The animal fixing device comprises a head fixing module, a trunk placing module and a bearing module, wherein the head fixing module, the trunk placingmodule and the bearing module are positioned at the front end, the middle and the tail part of the animal fixing device, the head fixing module is detachably connected with the trunk placing module,and the trunk placing module is detachably connected with the bearing module. The invention further discloses an application of the animal fixing device in nuclear magnetic resonance imaging of largeanimals, and the large animals are preferably monkeys, at least comprising cynomolgus monkeys and macaques. With the technical scheme, the influences of the body movement of the animals on imaging aregreatly improved, thus the data collecting quality is improved, and the experiment efficiency is further improved; the fixing device is compatible with a 9.4T nuclear magnetic resonance imaging device; by adopting the 3D printing technology, the cost of the product is greatly reduced, and meanwhile, the product forming speed is improved.

Description

technical field [0001] The invention relates to the technical field of nuclear magnetic resonance, in particular to an animal immobilization device and its application. Background technique [0002] Magnetic resonance imaging is one of the most important modern imaging methods for brain science research. In recent years, national brain projects have been launched one after another, such as the Human Connectome Project (HCP) in the United States and the "BRAIN Initiative" (BRAIN Initiative) formulated by the Obama administration in the United States in 2013. Therefore, high-field nuclear magnetic resonance imaging equipment is more and more favored by universities and research institutes, because its high magnetic field can greatly improve the signal-to-noise ratio and improve imaging resolution, and the high uniform and stable magnetic field can better realize time Synchronization with space, these hardware advantages can better help scientific researchers to explore and so...

AI Technical Summary

Problems solved by technology

Primates are closer to humans, and experimental research will have more advantages than mice and rats. However, the high-field small animal MRI equipment is specially used for fixed monkeys (mainly including cynomolgus monkeys and macaques). Fixtures are still a vacancy so far

Although there are some immobilization devices for monkeys on the market, such as surgical stereotaxic instruments and monkey chairs, these immobilization devices have their limitations: first, the size and bulk of these immobilization devices are too large to fit into 9.4T MRI equipment Second, many parts of these fixtures are made of metal. However, it is very dangerous to bring metal products into the NMR room. It will not only cause huge damage to the NMR equipment, but also endanger the lives of experimenters. Safety; thirdly, most of these existing fixtures need to be processed by machine tools, and some even need to be molded to manufacture, which usually leads to an increase in time and money costs

For Bruker 9.4T MRI equipment, the manufacturer’s own large animal bed can only be used to fix guinea pigs or rabbits. This animal bed is very simple, without a head fixation module and a heating module, and the lack of these two modules is fundamental. Unable to perform normal experimental operations and animal imaging

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