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Preparation method of capsules with high water retention

A water-retaining type and capsule technology, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of poor film-forming and water-retaining properties, achieve good film-forming properties, improve water-retaining properties, and water-retaining performance good effect

Inactive Publication Date: 2019-01-29
陈太师
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem to be solved by the present invention is to provide a method for preparing high water-retaining capsules in view of the defects of poor film-forming and water-retaining properties in current capsules

Method used

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  • Preparation method of capsules with high water retention

Examples

Experimental program
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Effect test

example 1

[0023] Take the water moss and put it into the steam explosion tank, and feed steam preheated to 220°C into the steam explosion tank until the pressure in the steam explosion tank reaches 2.2MPa. After keeping the pressure for 30s, open the discharge valve of the steam explosion tank to make the steam The material in the explosion tank is sprayed into the receiving tank instantaneously, and the material in the receiving tank is collected to obtain sphagnum fiber; the mass fraction is 40% chloroacetic acid solution and isopropanol are mixed evenly at a mass ratio of 3:4 to obtain a mixed solution, and the The above-mentioned sphagnum fiber, the mixed solution and the sodium hydroxide solution with a mass fraction of 20% are mixed according to a mass ratio of 2: 1: 1 and then packed into a three-necked flask, and nitrogen is introduced into the three-necked flask until all the air is replaced. Under nitrogen protection, heat up to 30°C and stir for 30 minutes to obtain a reactant...

example 2

[0025] Take sphagnum moss and put it into the steam explosion tank, and pass steam preheated to 230°C into the steam explosion tank until the pressure in the steam explosion tank reaches 2.3MPa. After maintaining the pressure for 35s, open the steam explosion tank discharge valve to make the The material in the explosion tank is sprayed into the receiving tank instantaneously, and the material in the receiving tank is collected to obtain sphagnum fiber; the mass fraction is 40% chloroacetic acid solution and isopropanol are mixed evenly at a mass ratio of 3:4 to obtain a mixed solution, and the The above-mentioned sphagnum fiber, the mixed solution and the sodium hydroxide solution with a mass fraction of 20% are mixed according to a mass ratio of 2: 1: 1 and then packed into a three-necked flask, and nitrogen is introduced into the three-necked flask until all the air is replaced. Under nitrogen protection, heat up to 35°C and stir for 35 minutes to obtain a reactant containin...

example 3

[0027]Take the water moss and put it into the steam explosion tank, and pass steam preheated to 240°C into the steam explosion tank until the pressure in the steam explosion tank reaches 2.4MPa. After keeping the pressure for 40s, open the discharge valve of the steam explosion tank to make the steam explosion tank The material in the explosion tank is sprayed into the receiving tank instantaneously, and the material in the receiving tank is collected to obtain sphagnum fiber; the mass fraction is 40% chloroacetic acid solution and isopropanol are mixed evenly at a mass ratio of 3:4 to obtain a mixed solution, and the The above-mentioned sphagnum fiber, the mixed solution and the sodium hydroxide solution with a mass fraction of 20% are mixed according to a mass ratio of 2: 1: 1 and then packed into a three-necked flask, and nitrogen is introduced into the three-necked flask until all the air is replaced. Under nitrogen protection, heat up to 40°C and stir for 40 minutes to obt...

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Abstract

The invention relates to the technical field of preparation of film-forming materials used for capsules, and in particular relates to a preparation method of capsules with high water retention. The preparation method comprises the following steps: preparing sphagna fibers by adopting sphagna as a raw material, enabling the sphagna fibers to react with chloroacetic acid under the existence of alkali, thus etherified sphagna fibers are prepared, carrying out mixing for gum dissolving on the etherified sphagna fibers, potato starch plant gum, water and sorbitol, and placing the obtained product in an empty capsule making machine, so that the capsules with high water retention are prepared. Sphagna is a pure natural product, the use of sphagna can improve the water retention of the capsules prepared by adopting the method, so that the shelf life is prolonged, chloroacetic acid and the sphagna fibers react under the existence of alkali, then the etherified sphagna fibers are prepared, further, the etherified sphagna fibers form an adhesive solution after being dissolved in water, in addition, potato starch plant gum has the water retention function, sorbitol also has the water retentionfunction, meanwhile, sorbitol is less volatile polyhydric alcohol, and is a good stabilizer, thus the prepared capsules have the excellent water retention and good stability, and have a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of preparing film-forming materials for capsules, in particular to a method for preparing high water-retaining capsules. Background technique [0002] Capsules are widely used in the pharmaceutical, health care and functional food industries, and are one of the most commonly used dosage forms for pharmaceuticals and functional foods. It has many advantages such as beautiful appearance, good for covering up the smell and taste of the drug in it, isolation protection, full absorption, easy to meet the requirements of positioning and timed drug release, simple preparation process, and convenient charging and use. [0003] Most of the empty capsules used in pharmaceutical factories are made of animal gelatin, which is mainly made of bone glue and skin glue extracted from animal skin and bones. Animal gelatin has the following disadvantages: (1) gelatin molecules are easily cross-linked with formaldehyde, reduci...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/26A61K47/46
CPCA61K9/4816
Inventor 陈太师陈珺赵金晶
Owner 陈太师
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