Composition of compound sustained-release drug delivery system capable of alleviating pain for long term and promoting wound healing and application

Abstract

The invention belongs to the field of pharmacy, and mainly relates to a composition of a compound sustained-release drug delivery system capable of alleviating pain for a long term and promoting woundhealing and application. The main drug of the system is a composition of a local analgesic drug and a non-steroidal anti-inflammatory drug, and further comprises a solvent and a corresponding sustained-release material. The main drug adopts a local analgesic drug and non-steroidal anti-inflammatory drug compound, the local analgesic drug can remedy the poor pain alleviating effect of the non-steroidal anti-inflammatory drug used alone, and can enhance the pain alleviating effect by reducing the pain sensitivity of an organism, inhibit inflammatory response and promote wound healing; and in addition, the combined use of the local analgesic drug and the non-steroidal anti-inflammatory drug can reduce the administration dosages of the local analgesic drug and the non-steroidal anti-inflammatory drug to reduce respective adverse reactions.

Description

technical field [0001] The invention belongs to the field of pharmacy, and mainly relates to the composition and application of a compound slow-release drug delivery system for long-acting analgesia and promoting wound healing. Background technique [0002] Nociceptive pain caused by surgery, knife wounds, burns, etc. is the most common clinical acute pain that requires urgent treatment. If this kind of pain is not controlled in time, it will not only have a significant impact on the patient's psychological and physiological organ functions, such as: anxiety, insomnia, irritability, nausea and vomiting, urinary retention, immunosuppression, pulmonary complications, blood pressure, etc. and increased risk of myocardial ischemia. Currently, up to 70% of patients are dissatisfied with the effect of postoperative analgesia, and 25%-55% of postoperative acute pain will develop into chronic pain, which lasts for half a year or even decades, and even leads to disability. [0003]...

AI Technical Summary

Problems solved by technology

[0014] Clinical investigations show that the drugs currently used clinically for long-acting analgesia are relatively single, all of which are water-based preparations and have a short duration of action.

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