High-speed non-contact photoacoustic imaging system based on combination of optical path modulation and sensitivity compensation

A technology of sensitivity compensation and photoacoustic imaging, which is applied in medical science, sensors, diagnostic recording/measurement, etc., can solve problems such as image quality degradation, large noise interference, under-compensation, etc., to achieve practical improvement, increase acquisition rate, expand The effect of application range

Inactive Publication Date: 2019-02-22
东北大学秦皇岛分校
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Problems solved by technology

However, this method fails to consider the problem that the sensitivity calculation in the low-sensitivity area (close to 0) is greatly disturbed by noise, and it is easy to cause over-compensation or under-compensation in this area, resulting in image quality degradation

Method used

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  • High-speed non-contact photoacoustic imaging system based on combination of optical path modulation and sensitivity compensation
  • High-speed non-contact photoacoustic imaging system based on combination of optical path modulation and sensitivity compensation
  • High-speed non-contact photoacoustic imaging system based on combination of optical path modulation and sensitivity compensation

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Embodiment Construction

[0043] Such as figure 1 As shown, a high-speed non-contact photoacoustic imaging system based on optical path modulation combined with sensitivity compensation, including a laser light emitting part, a reference arm, a sample end part, a detection end part and a data processing part;

[0044] The laser light-emitting part includes a long coherent light source 1, a first circulator 2 and a coupler 6, and the light beam of the long coherent light source 1 enters the coupler 6 through the first circulator 2 to be coupled;

[0045] The coupler 6 is respectively connected to the reference arm and the sample end, and the light beam is divided into two paths after passing through the coupler 6, one of which enters the reference arm and the other enters the sample end;

[0046] The reference arm includes a first lens 5, a second lens 4 and a first mirror 3;

[0047] The sample end portion sequentially includes a second focusing lens 20, a dichroic mirror 21, a second mirror 22, an X-...

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Abstract

The invention discloses a high-speed non-contact photoacoustic imaging system based on combination of optical path modulation and sensitivity compensation. The system is characterized by comprising alaser emitting part, a reference arm, a sample-side part, an exploring-side part and a data processing part. By sending multiple pulse signals at equal intervals, a laser generator is triggered to emit multiple laser pulses to excite a sample, and meanwhile, the optical path of the reference arm is modulated in order to make at least one excited photoacoustic signal positioned outside a low-sensitivity area; the photoacoustic signals positioned outside the low-sensitivity area are selected for sensitivity compensation in order to increase the collection speed.

Description

technical field [0001] The invention relates to the field of sports equipment, in particular to a high-speed non-contact photoacoustic imaging system based on optical path modulation combined with sensitivity compensation. Background technique [0002] Photoacoustic imaging is a non-invasive imaging method that combines the high contrast of pure optical imaging with the high resolution and high penetration depth of pure ultrasound imaging. Photoacoustic imaging uses the differences in light absorption of biological tissues to perform imaging. It can provide people with multi-dimensional information about the structure, metabolism, function, molecular comparison, hemodynamics, and gene expression of biological tissues, and provide information for the biomedical field. A novel imaging method was developed. [0003] At present, according to the different photoacoustic signal detection methods in photoacoustic imaging, it can be divided into non-contact photoacoustic imaging an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0095
Inventor 马振鹤孟祥和于孟含罗树卓赵玉倩刘健于瑶刘箫笛王毅
Owner 东北大学秦皇岛分校
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