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Flexible stretchable biosensor and preparation method thereof

A biosensor, flexible technology, applied in the field of flexible sensors, can solve the problems of reduced detection sensitivity, difficult signal acquisition and acquisition, complex structure, etc.

Inactive Publication Date: 2019-02-26
BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Utah electrodes and Michigan electrodes are commonly used in the market to detect electrical signals of the cerebral cortex, but the Utah electrodes and Michigan electrodes are rigid devices, which are difficult to fit the shape of biological tissues and thus restrict signal acquisition and acquisition.
At the same time, both the Utah electrode and the Michigan electrode need to integrate a lot of electronic components on the silicon substrate, and the structure is complex; moreover, the detection sensitivity will be reduced due to the heating of the electronic components during use.

Method used

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  • Flexible stretchable biosensor and preparation method thereof

Examples

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preparation example Construction

[0053] In the present invention, the preparation method of the flexible and stretchable biosensor comprises the following steps:

[0054] Carrying out encapsulation and stretching of carbon nanotube braids in sequence on the flexible film substrate to obtain a stretched flexible film substrate;

[0055] Print a plurality of working electrodes and a plurality of signal transmission channels on the surface of the stretched flexible film substrate, and then release the stretched flexible film substrate to obtain a flexible film precursor; wherein the working electrodes and the flexible film precursor in the flexible film precursor The signal transmission channel has a corrugated structure corresponding to the flexible film substrate;

[0056] The signal transmission channel on the surface of the flexible film precursor is encapsulated to obtain a flexible and stretchable biosensor.

[0057] In the invention, the encapsulation treatment and stretching treatment of the carbon nano...

Embodiment 1

[0082] according to figure 1 The structure shown is to prepare flexible and stretchable biosensors; 1-polydimethylsiloxane film substrate, 2-graphene / nano silver composite conductive ink working electrode, 3-parylene encapsulation structure, 4- Graphene / nano-silver composite conductive ink signal transmission channel:

[0083] After cleaning the polydimethylsiloxane film with deionized water, air-dry it at 80° C. to obtain the cleaned polydimethylsiloxane film;

[0084] The cleaned polydimethylsiloxane film is subjected to encapsulation treatment, stretching treatment and ultraviolet surface modification technology treatment by carbon nanotube braid to obtain a stretched flexible film substrate;

[0085] Stretch the net, make a positive base plate, apply photosensitive glue, expose to the net for 5 minutes, develop for 5 hours and harden the film for 15 minutes to obtain a printing plate;

[0086]Use described printing plate, print working electrode and signal transmission c...

Embodiment 2

[0089] according to figure 1 The structure shown is to prepare flexible and stretchable biosensors; 1-polydimethylsiloxane film substrate, 2-graphene / nano silver composite conductive ink working electrode, 3-parylene encapsulation structure, 4- Graphene / nano-silver composite conductive ink signal transmission channel:

[0090] After cleaning the polydimethylsiloxane film with absolute ethanol, air-dry it at 90° C. to obtain the cleaned polydimethylsiloxane film;

[0091] The cleaned polydimethylsiloxane film is subjected to encapsulation treatment, stretching treatment and ultraviolet surface modification technology treatment by carbon nanotube braid to obtain a stretched flexible film substrate;

[0092] Stretch the net, make a positive base plate, apply photosensitive glue, expose to the net for 5 minutes, develop for 5 hours and harden the film for 15 minutes to obtain a printing plate;

[0093] Use described printing plate, print working electrode and signal transmission...

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Abstract

The invention provides a flexible stretchable biosensor. The flexible stretchable biosensor has the advantages that the structure is simple, multiple working electrodes and multiple signal transmission channels are designed on a flexible film substrate, and it can be ensured that after one electrode goes wrong, other electrodes can work normally, thereby improving the safety of the biosensor, improving the accuracy of signal measurement and reducing the measurement error. The invention further provides a preparation method of the flexible stretchable biosensor, which has the advantages that the tensile property of the biosensor can be enhanced, and the conformability between the flexible stretchable biosensor and a measured object can be improved.

Description

technical field [0001] The invention relates to the technical field of flexible sensors, in particular to a flexible and stretchable biosensor and a preparation method thereof. Background technique [0002] Neurological diseases can cause loss of control of limb movement, cognitive dysfunction, etc., causing patients to lose part or all of their working ability, and impose a heavy burden on individuals, families and society. More than 1 billion people around the world suffer from neurological diseases, which have become a major threat to human health. When neurological diseases occur, abnormal discharges occur in the cerebral cortex. Therefore, in this case, timely collection of nerve electrophysiological signals is very important for the diagnosis of neurological disorders, treatment testing and rehabilitation training. [0003] At present, Utah electrodes and Michigan electrodes are commonly used in the market to detect electrical signals of the cerebral cortex. However,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0476
CPCA61B2562/02A61B5/369
Inventor 刘儒平石月李舟李烨李路海
Owner BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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