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Valsartan amlodipine compound tablet and preparation method thereof

A technology of compound tablet and amlodipine besylate, which is applied in the field of medicine, can solve the problems such as the decrease of dissolution rate, and achieve the effects of stable dissolution rate, reduced rate of decline and ensuring effectiveness

Active Publication Date: 2019-03-01
海南妙音春制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by this invention is to overcome the deficiencies in the prior art and improve the problem that the dissolution rate of valsartan amlodipine compound tablet decreases during the shelf life

Method used

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  • Valsartan amlodipine compound tablet and preparation method thereof
  • Valsartan amlodipine compound tablet and preparation method thereof
  • Valsartan amlodipine compound tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Each component in the valsartan amlodipine compound tablet described in the present embodiment and consumption thereof are shown in the following table:

[0035]

[0036]

[0037] The preparation method is as follows: mix the valsartan, amlodipine besylate, microcrystalline cellulose PH 112, cross-linked povidone and colloidal silicon dioxide in a mixer, and granulate through a dry granulator. Finally, add the magnesium stearate of formula quantity again, after mixing, compressing tablet both obtains.

Embodiment 2

[0039] Each component in the valsartan amlodipine compound tablet described in the present embodiment and consumption thereof are shown in the following table:

[0040] components

[0041] The preparation method is as follows: mixing valsartan, amlodipine besylate, microcrystalline cellulose PH 112, microcrystalline cellulose PH113, crospovidone and colloidal silicon dioxide in a mixer, After being granulated by a dry granulator, the formula amount of magnesium stearate is added, mixed evenly, and then compressed into tablets.

Embodiment 3

[0043] Each component in the valsartan amlodipine compound tablet described in the present embodiment and consumption thereof are shown in the following table:

[0044] components

[0045] The preparation method is as follows: valsartan, amlodipine besylate, microcrystalline cellulose PH 112, microcrystalline cellulose PH 113, hydroxypropyl-β-cyclodextrin, crospovidone and The colloidal silicon dioxide is mixed evenly in a mixer, and after being granulated by a dry granulator, the prescribed amount of magnesium stearate is added, mixed evenly, and compressed into tablets.

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PUM

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Abstract

The invention relates to a valsartan amlodipine compound tablet and a preparation method thereof. The compound tablet is prepared from, by weight, 40-160 parts of valsartan, 5-10 parts of amlodipine besylate, 30-80 parts of filler, 8-35 parts of cross-linked polyvinylpolypyrrolidone, 0.5-5 parts of colloidal silicon dioxide and 1-10 parts of magnesium stearate. The valsartan amlodipine compound tablet is relatively stable in dissolubility, and as time goes on in a shelf period, dissolubility decline is evidently reduced, and pharmaceutical effectiveness is guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound tablet of valsartan and amlodipine and a preparation method thereof. Background technique [0002] Hypertension refers to a clinical syndrome characterized by elevated systolic and / or diastolic blood pressure, accompanied by functional or organic damage to heart, brain, kidney and other vital organs. Generally speaking, hypertension can be diagnosed when the systolic blood pressure ≥ 140 mm Hg and diastolic blood pressure ≥ 90 mm Hg measured at three different times. Hypertension is one of the common chronic diseases in my country and one of the most important risk factors for cardiovascular and cerebrovascular diseases. The incidence of hypertension is hidden, and the incidence rate gradually increases with age, and a large part of patients with hypertension have no obvious symptoms, resulting in a low awareness rate, treatment rate and control rate of the disease. ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K31/41A61K31/4422A61P9/12
CPCA61K9/2009A61K9/2027A61K9/2054A61K31/41A61K31/4422A61P9/12A61K2300/00
Inventor 赖海杰赖木水吴友世
Owner 海南妙音春制药有限公司
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