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Pharmaceutical composition for preventing and treating haemophilus parasuis as well as preparation method and application thereof

A technology for Haemophilus suis disease and a composition, applied in the field of traditional Chinese veterinary medicine, can solve the problems of unsatisfactory immune control effect, loss of pig industry, poor treatment effect and the like

Inactive Publication Date: 2019-03-01
JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since Haemophilus parasuis has 15 serotypes, although there are vaccines for production and application, the effect of immune control is not ideal
In pig production, many pigs are treated with antibiotics after the onset of the disease, making many strains of Haemophilus parasuis resistant to antibiotics, so some susceptible pigs in some pig farms do not do drug sensitivity tests after the onset of the disease, and blindly use antibiotics Treatment, the treatment effect is poor, which brings great losses to my country's pig industry

Method used

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  • Pharmaceutical composition for preventing and treating haemophilus parasuis as well as preparation method and application thereof
  • Pharmaceutical composition for preventing and treating haemophilus parasuis as well as preparation method and application thereof
  • Pharmaceutical composition for preventing and treating haemophilus parasuis as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Composition: 19g thorn red beads, 8g saxifrage, 10g sorbus stem bark, 17g black face god.

[0056] The specific preparation process is as follows:

[0057] Mix thorn red bead, saxifrage, sorbus stem bark, and black face god, add 4 times the total weight of the medicinal materials, soak in distilled water for 24 hours, then decoct 3 times, each time after boiling for 0.5 hours, combine the decoction and concentrate To a thick shape, add 95% ethanol by weight to adjust the alcohol concentration to 70%, stir and mix well, stand for precipitation for more than 48 hours, filter, and recover ethanol from the filtrate, and add the concentration to 95% after the ethanol is recovered. Adjust the ethanol to 75% alcohol concentration, stir, let stand for 48 hours, filter, the filtrate recovers the ethanol, and then concentrates until no alcohol taste, add 4 times the amount of distilled water to the obtained liquid medicine, refrigerate precipitation for 48 hours, filter, The filtrate...

Embodiment 2

[0059] Composition: 19g thorn red beads, 10g saxifrage, 12g sorbus stem bark, 17g black face god.

[0060] The specific preparation process is as follows:

[0061] Mix thorn red beads, saxifrage, sorbus stem bark and black face god, add 3 times the total weight of the medicinal materials, soak in distilled water for 24 hours, decoct 2 times, keep for 1 hour after each boiling, combine the decoction and concentrate To thick, add 95% ethanol by weight to adjust to 60% alcohol concentration, stir and mix well, let stand for more than 48 hours, filter, and recover ethanol from the filtrate. Add 95% ethanol to the solution after ethanol recovery. Adjust the ethanol to an alcohol concentration of 80%, stir well, let stand for 48 hours, filter, and recover the ethanol from the filtrate, and then concentrate until there is no alcohol smell. Add 4 times the amount of distilled water to the obtained drug solution to cool and precipitate for 48 hours, filter, and concentrate the filtrate , T...

Embodiment 3

[0063] Recipe: 51g thorn red beads, 16g saxifrage, 22g sorbus stem bark, 45g black face god

[0064] The specific preparation process is as follows:

[0065] Mix thorn red beads, saxifrage, sorbus stem bark, and black face god, add 4 times the total weight of the medicinal materials, soak in distilled water for 30 hours, decoct 2 times, keep for 1 hour after each boiling, combine the decoction and concentrate To thick, add 95% ethanol by weight to adjust to 60% alcohol concentration, stir and mix well, let stand for more than 48 hours, filter, and recover ethanol from the filtrate. Add 95% ethanol to the solution after ethanol recovery. Adjust the ethanol to an alcohol concentration of 75%, stir well, let stand for 48 hours, filter, the filtrate recovers the ethanol, and then concentrates until no alcohol taste, add 4 times the amount of distilled water to the obtained drug solution and refrigerate precipitation for 60 hours, filter, and concentrate the filtrate , To obtain a medi...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating haemophilus parasuis as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following medicines in parts by weight: 17-51 parts of berberis dictyophylla, 6-18 parts of saxifraga unguiculata, 9-27 parts of sorbus pohuashanensis stem bark and 15-45 parts of breynia fruticosa. The pharmaceutical composition is capable of treating both symptoms and root causes, has the advantages of high overall treatment effect, short treatment course, low in possibility of generation of drug resistance and low in residue, is capable of accelerating the healthy development of the pig farming industry, and has extremely important economic benefit and social benefit.

Description

Technical field [0001] The invention belongs to the field of Chinese veterinary medicine, and more specifically, relates to a pharmaceutical composition for preventing and treating Haemophilus parasuis disease. Background technique [0002] Haemophilus parasuis is a contact bacterial infectious disease of pigs caused by Haemophilus parasuis (HPS), also known as Gramser's disease, which is distributed worldwide, and it also occurs in pig farms in my country. Haemophilus parasuis mainly infects young pigs aged 2 weeks to 3 months, especially pigs aged 5 to 8 weeks, and the mortality rate can reach 50%. The main clinical manifestations are fever, loss of appetite or anorexia, eyelid edema, purulent secretions around the nostrils, unresponsiveness, coughing, dyspnea, ataxia, joint swelling, and claudication. Macroscopic lesions include fibrinous inflammation of the pleura, peritoneum, pericardium, joint serous membrane, and even meningeal membrane, which is manifested by the appeara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P31/04
CPCA61K36/185A61K36/29A61K36/47A61K36/73A61K2236/331A61K2236/39A61K2236/55A61P31/04A61K2300/00
Inventor 傅宏庆姚志兰涂常松周广生黄东璋
Owner JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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