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Black phosphorus quantum dot/platinum hybrid mesoporous silica nanoparticles and preparation method and application thereof

A mesoporous silica and nanoparticle technology, applied in nanotechnology, nanomedicine, nanotechnology, etc., can solve the problem of poor stability of black phosphorus quantum dot solution, and achieve the effect of improving the effect of photodynamic therapy and improving the stability.

Active Publication Date: 2019-03-08
MENGCHAO HEPATOBILIARY HOSPITAL OF FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem of poor stability of black phosphorus quantum dot solution in the prior art, the present invention provides a black phosphorus quantum dot / platinum hybrid mesoporous silica nanoparticle and its preparation method and application

Method used

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  • Black phosphorus quantum dot/platinum hybrid mesoporous silica nanoparticles and preparation method and application thereof
  • Black phosphorus quantum dot/platinum hybrid mesoporous silica nanoparticles and preparation method and application thereof
  • Black phosphorus quantum dot/platinum hybrid mesoporous silica nanoparticles and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Take 10ml of the purchased multi-layer black phosphorus DMF solution (BP, 200 μg / ml), place it in an ice bath, ultrasonicate it for 8 hrs under an ultrasonic cell pulverizer (power 600W), and then transfer it to an ultrasonic cleaner (power 500W), Sonicate in an ice bath for 10hrs, centrifuge at 2000rpm / min for 10min, take the supernatant, then centrifuge at 20000rpm / min for 20min, collect the precipitate, resuspend with 1ml ultrapure water, and put it in a 4°C refrigerator for later use.

[0032] Weigh 2 g of cetyltrimethylammonium chloride (CTAC) and 20 μg of triethanolamine and dissolve them in 20 mL of ultrapure water. After ultrasonication for 10 min, add 1 mL of the BPQDs aqueous solution prepared above into the mixture and stir for 1 hr, then Heat to 80°C; when the temperature reaches 80°C, slowly add 1.5mL tetraethyl orthosilicate (TEOS) dropwise, stir for 1 hour, centrifuge (12000rpm / min) for 15min, remove the supernatant, wash the precipitate with absolute etha...

Embodiment 2

[0035] Example 1 The size of the composite nanomaterial prepared in Example 1 is about 50-100 nm, which has high stability and photodynamic effect and can be used for photodynamic therapy of tumors.

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Abstract

The invention discloses black phosphorus quantum dot / platinum hybrid mesoporous silica nanoparticles and a preparation method and application thereof. The black phosphorus quantum dots / platinum hybridnanoparticles loaded with platinum nanoparticle in mesopores are synthesized through a one-step hydrothermal method and an in-situ growth method, so that the solution stability of black phosphorus quantum dots can be significantly improved; and hydrogen peroxide in tumor microenvironment undergoes catalytic reaction with the platinum nanoparticles to form oxygen, so that the photodynamic therapyeffect, of the black phosphorus quantum dots, on tumors is further enhanced, and then a good biomedical application prospect is provided.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial manufacturing, and in particular relates to a black phosphorus quantum dot / platinum hybrid mesoporous silica nanoparticle and a preparation method and application thereof. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the common malignant tumors in the digestive system. It has the characteristics of easy metastasis, rapid proliferation, and high recurrence. Its incidence rate is increasing year by year, which seriously threatens human health. my country is a big country with liver cancer, and half of the newly diagnosed liver cancer patients in the world every year are from China. Currently, surgical treatment is the main treatment for liver cancer; however, surgical treatment will lose the opportunity of surgery due to factors such as tumor location, size, and physical tolerance of the patient. In recent years, the photodynamic therapy strategy developed based on na...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/52A61K47/69A61P35/00B82Y5/00
CPCA61K41/0057A61K47/52A61K47/6949A61P35/00B82Y5/00
Inventor 张达曾永毅刘景丰刘小龙
Owner MENGCHAO HEPATOBILIARY HOSPITAL OF FUJIAN MEDICAL UNIV
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