Diclazuril-containing composition, and preparation method and application thereof

Abstract

The invention discloses a diclazuril-containing composition, a preparation method and the application thereof. The composition contains urea-coated diclazuril microparticles. During the preparation ofthe composition, urea liquid is firstky prepared, and then diclazuril is added thereinto; the urea liquid and the diclazuril are uniformly stirred and mixed, and then the mixture is cured to obtain urea-coated diclazuril solid microparticles; the diclazuril is wrapped with the microparticles to be isolated from air, so that the stability is greatly improved; furthermore, the composition is very fluid, easy to mix and easy to use; the composition is easily soluble in water and has high bioavailability; the preparation method is simple and favorable for industrialization and industrial production.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a composition containing diclazuril, a preparation method and application thereof. Background technique [0002] Diclazuril is a veterinary anticoccidial drug of the lanzo class. It has the characteristics of broad spectrum, high efficiency, and low toxicity. It is currently one of the most widely used anticoccidial drugs with the best effect. Although the mechanism of diclazuril's anti-coccidia action is not clear yet, it has good effects on chicken tenderness, heap type, poison, Brucella, giant Eimeria, duck coccidia and rabbit coccidia. Effect. The peak period of its main action on coccidia varies with the different species of coccidia. For example, the main action point on Eimeria tenella is in the sexual cycle of the second generation of schizont coccidia, but for giant, Brucella Eimeria schizont is ineffective; the point of action on Eimeria giantis...

AI Technical Summary

Problems solved by technology

Most of the diclazuril premixes that have been on the market are powders. Although the preparation process is simple and the transportation is convenient, its fluidity and uniformity are poor, it is difficult to mix with feed, and it is easy to separate during use, which is inconvenient to use; At present, although it is used after being prepared into granules with suitable auxiliary materials, the fluidity and mixing uniformity are solved to a certain extent, but in order to ensure the uniformity of the content of diclazuril in the granules, diclazuril needs to be added After superfine mixing and pulverization of Zhuli and surfactant, it is then mixed and granulated with common diluents, which requires high equipment, low production efficiency, and is difficult to realize industrialization

Diclazuril solution is mainly added to animal diets for use. It has the advantages of being easy to use and easy to mix evenly with water. However, diclazuril is mainly made into a liquid by adding solubilizers, co-solvents and organic solvents. Therefore, the stability of the preparation is relatively poor, and the effective period of the diclazuril aqueous solution prepared is only 4 hours, and the toxicity and irritation are large, the bioavailability after medication is low, and the body is harmful

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