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Antitumor nanoparticles and preparation method and preparation thereof

A nanoparticle, anti-tumor technology, used in anti-tumor drugs, pharmaceutical formulations, antibody medical ingredients, etc., can solve the problem of inability to prevent tumor recurrence, and achieve the effects of enhancing self-immunity, fast response, and wide applicability

Active Publication Date: 2019-03-19
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The third object of the present invention is to provide the application of the above-mentioned anti-tumor nanoparticles in the preparation of drugs for treating tumors, so as to alleviate the problems that the existing methods of treating tumors in the prior art not only face various side effects, but also cannot prevent tumor recurrence. technical problem

Method used

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  • Antitumor nanoparticles and preparation method and preparation thereof

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preparation example Construction

[0065] Such as figure 1 As shown, the present invention also provides the preparation method of the above-mentioned anti-tumor nanoparticles, including:

[0066] The high molecular organic compound-photosensitizer nanoparticle is provided, and then the immune adjuvant is coated on the high molecular organic compound-photosensitizer nanoparticle to obtain the anti-tumor nanoparticle.

[0067] The preparation method of the above-mentioned anti-tumor nanoparticles provided by the present invention is simple in operation, easy to master, wide in applicability, effectively reduces the cost, and is easy to realize large-scale production.

[0068] In a preferred embodiment, the photosensitizer in the macromolecule organic compound-photosensitizer nanoparticles is a porphyrin compound, a phthalocyanine compound or a fluorescent dye, preferably a porphyrin derivative, a metal phthalocyanine compound or a boron fluoride Fluorescent dyes, more preferably one or more of four (4-carboxyph...

Embodiment 1

[0088] This embodiment provides an anti-tumor nanoparticle, comprising:

[0089] A core, a wrapper covering the core, and an immune layer covering the wrapper.

[0090] Among them, the core is medium-tetrakis(4-carboxyphenyl)porphine (TPP), the wrapping layer is polyethylene glycol-polylactic acid-glycolic acid copolymer (mPEG(2000)-PLGA), and the immune layer is human malignant non-cholesterol Cell membranes of natural killer cells (NK-92 cells) from a patient with Chiggin's lymphoma.

Embodiment 2

[0092] This embodiment provides an anti-tumor nanoparticle, comprising:

[0093] A core, a wrapper covering the core, and an immune layer covering the wrapper.

[0094] Among them, the core is chlorin (Ce6), the wrapping layer is polyethylene glycol-polylactic acid-glycolic acid copolymer, and the immune layer is the cell membrane of natural killer cells of human malignant non-Hodgkin's lymphoma patients.

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Abstract

The invention provides antitumor nanoparticles and a preparation method and preparation thereof and relates to the technical field of nano-medicine. Each antitumor nanoparticle comprises a core, a wrapping layer coating the core and an immune layer coating the wrapping layer. The antitumor nanoparticles obtained by wrapping nanoparticles with an immune adjuvant can realize therapeutic effect combining photodynamics therapy and immune therapy, have selectivity to target tissue and injury degree and can reduce injury to normal tissue; the antitumor nanoparticles treat tumor by enhancing own immunity of a patient, is quick in response, free of side effect and lasting in therapeutic effect and can play an important role in preventing postoperative recurrence. The preparation method includes: providing high polymer organic compound-photosensitizer nanoparticles; coating the immune adjuvant outside the nanoparticles to obtain the antitumor nanoparticles. The method is simple in operation, easy to master and high in universality.

Description

technical field [0001] The invention relates to the technical field of nanomedicine, in particular to an anti-tumor nanoparticle and its preparation method and application. Background technique [0002] Cancer is the number one killer of human health. The 2014 World Health Organization (WHO) "World Cancer Report" data shows that the incidence and mortality of cancer are increasing year by year, and it is the most serious health problem facing the world. In 2012, the number of cases in China was 3.07 million, accounting for 21% of the global total, and the number of deaths was 2.2 million, accounting for 27% of the global total. The forecast for 2014 is that by 2030, the number of cases and deaths in China will be 5 million and 3.5 million respectively. . But in fact, by 2015, the latest data from the "World Cancer Report" shows that the number of cases in China has risen to 4.3 million, while the number of deaths has risen to 2.8 million. This data is shocking. According...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/46A61K41/00A61K49/00A61K39/39A61P35/00A61P37/04
CPCA61K39/39A61K41/0071A61K41/0076A61K49/005A61K49/0093A61K9/5068A61K9/5073A61K2039/55588A61K2039/57
Inventor 蔡林涛邓冠军孙枝红龚萍李三朋
Owner SHENZHEN INST OF ADVANCED TECH
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