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Micro-bubble preparation method, air supply system and preparation equipment

A gas supply system and microbubble technology, which is used in pharmaceutical formulations, microcapsules, nanocapsules, etc., can solve the problem of uneven concentration of microbubbles, difficult to ensure the consistency of microbubble concentration, and affect the consistency of microbubble product parameters, etc. problems, to achieve the effect of improving consistency

Inactive Publication Date: 2019-03-26
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The shortcomings of the above microbubble preparation method are: it is difficult to ensure the consistency of the microbubble concentration, and the prepared microbubble concentration value is not uniform
After repeated preparations of microbubbles, it was found that the concentration of microbubbles was more or less different from bottle to bottle. For industrialized batch production after scale-up, there were also differences in the concentration of microbubbles between batches; There are differences in microbubble concentration values ​​between bottles or batches, and there is a problem of poor consistency of microbubble concentration, which will not only affect the consistency of product parameters such as backscattering intensity of microbubbles or drug dosage, but also be difficult to meet Large-scale industrial batch production requires product quality safety or controllability, and there are currently no literature reports on how to fundamentally solve this problem

Method used

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  • Micro-bubble preparation method, air supply system and preparation equipment
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  • Micro-bubble preparation method, air supply system and preparation equipment

Examples

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preparation example Construction

[0097] As known in the art, conventional microbubble preparation methods can prepare microbubbles for targeted delivery. The main steps include: first dissolving drugs, genes or trace element ions and film-forming materials in water or organic solvents, making the drugs , genes or trace element ions are combined with the film-forming material through physical or chemical action to form a composite film, and then the previously obtained composite film is prepared into microbubbles by a preset method of generating microbubbles.

[0098] Since the toxicity and medicinal dosage of drugs or trace elements need to be accurately grasped, and the content of drugs or trace elements is closely related to the concentration of targeted delivery microbubbles, in order to ensure the consistency and accuracy of the content of drugs or trace elements The consistency and accuracy of microbubble concentration values ​​need to be controlled during the preparation process.

[0099] Film forming...

Embodiment approach

[0138]In other embodiments, other methods can also be used to determine the inflation pressure value, for example: in the case where the inflation volume value corresponding to the microbubble concentration value can be directly determined, the mapping relationship between the inflation volume value and the inflation pressure value can also be used Determine the inflation pressure value. The specific steps include: setting the inflation volume value; determining the inflation pressure value corresponding to the inflation volume value according to the preset mapping relationship between the inflation volume value and the inflation pressure value; Gas required for microbubbles. In this way, an effective control method for obtaining a value close to the expected microbubble concentration is provided, thereby bringing the beneficial effect of better accuracy of the microbubble concentration. As an implementation, the specific steps of determining the inflation pressure value incl...

Embodiment 1

[0183] Example 1: Air supply system of microbubble preparation device

[0184] Such as Figure 6 As shown, the gas supply system of the microbubble preparation device in this embodiment includes: a gas source 1 to provide the gas needed to form microbubbles; a gas path, one end of the gas path is connected to the gas source 1, and the other end of the gas path is connected to The gas inlet of reaction vessel 8; Inflatable volume control part, the inflatable volume control part can control the volume that is filled with gas to reaction vessel 8, and the gas source 1 in the present embodiment is a high-pressure gas cylinder, and it is stored with the gas required for forming microbubbles. gas. For example: perfluoropropane, sulfur hexafluoride or perfluorobutane, the high-pressure gas cylinder has a gas outlet, and the gas outlet is connected to one end of the gas circuit. The gas path in this embodiment mainly includes pipelines. Preferably, the gas path also includes struc...

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Abstract

The invention relates to a micro-bubble preparation method, which comprises the following steps that a membrane forming material is provided for a reaction container; air required for micro-bubble formation is filled into the reaction container; the filled air volume is controlled; air micro-bubbles wrapped by the membrane forming material are generated by a preset method. The problem of poor micro-bubble concentration value consistency of the existing preparation method is solved, so that the beneficial effect that the micro-bubble concentration value consistency is better is achieved.

Description

technical field [0001] The invention relates to the field of microbubble preparation, in particular to a microbubble preparation method, a gas supply system and preparation equipment thereof. Background technique [0002] Closed micron-sized gas-containing microbubbles are often used in medical ultrasound imaging as a diagnostic reagent for enhancing medical ultrasound imaging signals—ultrasound contrast agents. [0003] In medical ultrasound imaging, each fine structure in the tissue is used as the scatterer of ultrasound. When the ultrasound beam encounters a cross section smaller than the emission wavelength, scattering occurs. Scattering waves exist in any direction, and the scattering opposite to the emission direction of the probe is called backscattering. , the probe of the ultrasonic diagnostic instrument receives backscattered signals to realize tissue imaging. [0004] Ultrasound contrast agent is a suspension composed of a large number of microbubbles dispersed i...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K9/51A61K47/42A61K47/24A61K47/12A61J3/07
CPCA61J3/07A61K9/5123A61K9/5169A61K9/5192A61K49/223
Inventor 康裕建冯琦璞
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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