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A kind of ru-bsa hydrogel and its preparation method and application

A hydrogel and gel technology, which is applied in the field of medicine, can solve the problems of toxicity, short metabolism time, increased toxic and side effects of drugs, etc., and achieve the effects of easy ingestion, improved curative effect, and improved utilization rate.

Active Publication Date: 2022-04-15
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Platinum, ruthenium and other metal complex drugs are small molecule drugs, which have certain limitations: small molecule drugs have a short metabolism time in the body and will be quickly metabolized out of the body, resulting in a small amount of drug accumulation in tumor tissues. In order to achieve therapeutic effects , can only increase the intake, which will cause toxicity caused by dose, coupled with the characteristics of non-specific absorption and wide distribution in the body of small molecule drugs, which will increase the toxicity and side effects of drugs

Method used

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  • A kind of ru-bsa hydrogel and its preparation method and application
  • A kind of ru-bsa hydrogel and its preparation method and application
  • A kind of ru-bsa hydrogel and its preparation method and application

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Embodiment Construction

[0029] The present invention provides a Ru-BSA hydrogel and its preparation method and application. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0030] The embodiment of the present invention provides a Ru-BSA hydrogel (ruthenium complex-bovine serum albumin hydrogel), wherein the Ru-BSA hydrogel is mainly composed of a ruthenium complex and bovine serum albumin gel;

[0031] The structural formula of the ruthenium complex is as follows:

[0032] ;

[0033] The structural formula of the bovine serum albumin gel is as follows:

[0034]

[0035] The structural formula of the Ru-BSA hydrogel is as follows:

[0036] ;

[0037] in, .

[0038] In this example, the selected ruthenium complexes ...

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Abstract

The invention discloses a Ru-BSA hydrogel, a preparation method and application thereof. The structural formula of the Ru-BSA hydrogel is as follows:; wherein,. In the present invention, the Ru-BSA hydrogel is more easily taken up by cancer cells, and the bovine serum albumin in the Ru-BSA hydrogel can be continuously enzymatically hydrolyzed in the in vivo environment, thereby continuously releasing drug molecules, improving the The utilization rate of the drug greatly improves the curative effect of the drug on the tumor.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Ru-BSA hydrogel and its preparation method and application. Background technique [0002] Cancer is a malignant tumor, which is a disease caused by the infinite proliferation of cancer cells due to the abnormality of the mechanism of controlling cell division and proliferation. Cancer cells can infiltrate into normal tissues around the tumor, and can also transfer to other tissues in the body through the circulatory system and lymphatic system in the body, thus making the disease out of control. Due to the invasiveness of cancer cells, normal cells and cancer cells are often mixed together, so the targeting of anticancer drugs is particularly important. That is, it has low toxicity to normal cells, high toxicity to cancer cells, reduces damage to normal tissues, and reduces toxic and side effects. [0003] Platinum-based anticancer agents are the most widely used anticancer ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K9/06A61K31/555A61P35/00
CPCA61K47/42A61P35/00A61K9/06A61K31/555
Inventor 张平玉胡仁涛赵智泉张黔玲
Owner SHENZHEN UNIV
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