A kind of medicine for treating cervical cancer and its application
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A cervical cancer, drug technology, applied in the field of drugs
Inactive Publication Date: 2020-11-24
孙凤永
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Abstract
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In the same year, Ibrahim et al. discovered a new tetrahydrocarboline compound, Ingenine F, and investigated its effects on cell lines such as breast cancer, lung cancer, colon cancer, and cervical cancer. Dial and lung cancer A549 cells have cytotoxicity, but are ineffective against symp
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Embodiment 1
[0030] Example 1 Antitumor Oral Capsules
[0031] Aspirin 2400g
[0032] 1-Acetyl-β-carboline 200g
[0033] Lactose 873.5g
[0034] Povidone K30 78g
[0035] Anhydrous citric acid 69g
[0036] Purified water 700g.
[0037] Add the prescribed amount of povidone K30 and anhydrous citric acid into the purified water of the prescribed amount, and mix them as a binder; take the prescribed amount of aspirin, 1-acetyl-β-carboline and lactose and mix evenly, add the binder to prepare a soft material, Pass through a 18-mesh sieve, dry the wet granules at 50 degrees Celsius and pack into 10,000 capsules.
Embodiment 2
[0038] Example 2 Antitumor Oral Capsules
[0039] Aspirin 3000g
[0040] 1-Acetyl-β-carboline 200g
[0041] Lactose 1100g
[0042] Povidone K30 97g
[0043] Anhydrous citric acid 86g
[0044] Purified water 875g.
[0045] Add the prescribed amount of povidone K30 and anhydrous citric acid into the purified water of the prescribed amount, and mix them as a binder; take the prescribed amount of aspirin, 1-acetyl-β-carboline and lactose and mix evenly, add the binder to prepare a soft material, Pass through a 18-mesh sieve, dry the wet granules at 50 degrees Celsius and pack into 10,000 capsules.
Embodiment 3
[0046] Example 3 Antitumor Oral Capsules
[0047] Aspirin 3400g
[0048] 1-Acetyl-β-carboline 200g
[0049] Lactose 1100g
[0050] Povidone K30 97g
[0051] Anhydrous citric acid 86g
[0052] Purified water 875g.
[0053] Add the prescribed amount of povidone K30 and anhydrous citric acid into the purified water of the prescribed amount, and mix them as a binder; take the prescribed amount of aspirin, 1-acetyl-β-carboline and lactose and mix evenly, add the binder to prepare a soft material, Pass through a 18-mesh sieve, dry the wet granules at 50 degrees Celsius and pack into 10,000 capsules.
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Abstract
The invention belongs to the field of drugs and relates to a drug for the treatment of cervical cancer and use thereof. The drug is made from aspirin, a 1-position substituted beta-carbalin and pharmaceutical preparation excipients. Wherein the 1-position substituted beta-carbalin is selected from 1-acetyl-beta-carbalin or 1-methoxycarbonyl-beta-carbalin, and 1-acetyl-beta-carbalin is preferable.The ratio of aspirin of the drug and the 1-acetyl-beta-carbalin in mass is from 10:1 to 17:1. The dosage form of the drug is optimized as oral solid preparation. In the experimental study, it is foundthat the combination of the 1-acetyl-beta-carbalin and the aspirin has inhibitory effect on cervical cancer transplantation model and has the potential to be used in the treatment of cervical cancer.
Description
technical field [0001] The invention belongs to the field of drugs, and in particular relates to a drug for treating cervical cancer and its application. Background technique [0002] Cervical cancer is one of the most common malignant tumors in women, and its incidence rate is second only to ovarian cancer and breast cancer among female malignant tumors. Human papillomavirus infection is the main cause of cervical cancer, so human papillomavirus vaccination is currently the main means of cervical cancer prevention, but affected by economic factors, the vaccination rate in developing countries is low, the incidence of cervical cancer and Mortality rates are higher than in developed countries. According to statistics, there are 471,000 new cases of cervical cancer and 215,000 new deaths each year worldwide. In my country, 12.96 new cervical cancer patients are added every year, and the patients are young and middle-aged women, which cause serious economic and mental burdens...
Claims
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Application Information
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