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Process for preparing Hongjin stasis elimination tablet

A preparation process and a technology for eliminating junction tablets, which are applied in the field of pharmacy and can solve the problems of insufficiently clear spot color, long production cycle, and unfavorable large-scale production.

Active Publication Date: 2019-03-29
四川维奥制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the paper provides the preparation method and quality control method of Hongjin Xiaojie Tablets, some steps in the above-mentioned preparation process still need to be improved. For example, the use of combined concentration in the concentration step has the following disadvantages: (1) It takes three times to extract the filtrate. Concentrate after merging. After the three filtrates are combined, the amount is large, which is not conducive to continuous production; (2) After the three extractions are completed, the filtrates are combined and concentrated, and the filtrate storage time is longer, which increases the risk of microbial growth; (3) After the three extractions are completed, The filtrate is combined and concentrated again, and the whole extraction and concentration production cycle is long; (4) During the combination of the liquid medicine, the temperature drops, and when it is concentrated, it is heated again to increase energy consumption
Furthermore, the drying method of the concentrated thick paste in the above-mentioned production process is "mix the thick paste with the remaining five-flavored medicinal powders, dry, and pulverize". Mixing, due to the large amount of paste, it is difficult to mix and stir, which is not conducive to large-scale production; (2) The step of mixing thick paste with other five-flavored medicinal powders increases the risk of pollution; (3) After mixing thick paste and other five-flavored medicinal powders, it increases drying The production pressure of the process is not conducive to mass production and continuous production
Finally, the auxiliary materials in the above process are only the filler dextrin to adjust the tablet weight, and the lubricant magnesium stearate, which have the following disadvantages in large-scale production: (1) when granulating, the particles are loose and there are many powders; (2) tableting Low hardness and easy to break; (3) powder falling and fragments during the coating process, which makes the coating yield relatively low
Although this method can identify Bupleurum bupleuri, after unfolding, the R of the main board point f The value is large, which is not conducive to observation. At the same time, the spot color is not clear enough after the original color developer is developed.

Method used

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  • Process for preparing Hongjin stasis elimination tablet
  • Process for preparing Hongjin stasis elimination tablet
  • Process for preparing Hongjin stasis elimination tablet

Examples

Experimental program
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Effect test

Embodiment 1

[0058] Hongjin Xiaojie Tablets include raw materials: The Hongjin Xiaojie Tablets include raw materials: Spiced Spathiphyllum, Jiyateng, Golden Buckwheat, Dahongpao, Bupleurum, Panax notoginseng, Cyperus cyperi, Star anise lotus, Ratwort and Black ants; Among them, Panax notoginseng was purchased from Nanguo Trading Co., Ltd., Wenshan City, Yunnan Province, batch number: 20170901; Bupleurum was purchased from Rongxian Minzhong Traditional Chinese Medicine Planting Professional Cooperative, batch number is 20170801; Lot No.: 20170702), Ratwort (Lot No.: 20170703), Black Ant (Lot No.: 20170704), Spiced Bloodvine (Lot No.: 20170705), Chicken Yateng (Lot No.: 20170706), Golden Buckwheat (Lot No.: 20170707) and Dahongpao ( Batch number: 20170708) were purchased from Guang'an Xinsi Planting Professional Cooperative.

[0059] Main instruments and equipment of the present invention are as table 2:

[0060] Table 2 main equipment

[0061]

[0062] The preparation method of every 1...

Embodiment 2

[0085] The difference with Example 1 is that the weight of the dry paste powder is adjusted to be 232.5g, and the weight of dextrin is 0g

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Abstract

The invention provides a process for preparing Hongjin stasis elimination tablets and belongs to the technical field of pharmacy. To solve various problems in concentration modes in the prior art, drying modes of concentrated ointments, auxiliary materials and identification, a preparation process of the Hongjin stasis elimination tablets is further improved, including steps of directly concentrating extracts, independently drying ointments, increasing amounts of auxiliary materials such as low-substituted hydroxypropylcellulose, povidone K30 and magnesium stearate, and changing medicine identification items and content testing items, and furthermore the purposes of shortening production cycle, reducing energy consumption, reducing pollution risks and improving product quality are achieved.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation process of Hongjin Xiaojie Tablet. Background technique [0002] Hongjin Xiaojie Tablet is a new type of medicine refined from Hongjin Xiaojie Capsules based on modern scientific methods according to the different needs of patients. Spiced Sagevine, Chicken Yateng, Golden Buckwheat, Dahongpao and Bupleurum can soothe the liver and regulate qi, soften hard masses, activate blood circulation and remove blood stasis, reduce swelling and relieve pain, and are mostly used for breast lobular hyperplasia, uterine fibroids and ovarian cancer caused by qi stagnation and blood stasis. cyst. [0003] The preparation and quality control of Hongjin Xiaojie Tablets[J]. Xie Hai, Wang Shujun, Zhang Ying, et al. Chinese Modern Chinese Medicine, 2008,10(4):32-34. Disclosed the preparation method of Hongjin Xiaojie Tablets , including: take the prescription amount of Panax notogins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/28A61K47/38A61K47/32A61P15/14A61P15/00A61P35/00G01N30/88A61K35/64
CPCA61K9/2027A61K9/2054A61K9/2059A61K9/28A61K35/64A61K36/185A61K36/233A61K36/258A61K36/29A61K36/57A61K36/70A61K36/74A61K36/8905A61K2236/13A61K2236/15A61K2236/331A61K2236/51A61P15/00A61P15/14A61P35/00G01N30/88G01N2030/8809A61K2300/00
Inventor 尹华国刘航董国王艳蔡艳贝岳琴谢宇
Owner 四川维奥制药有限公司
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