Hydrogel for repairing endometrium injury and preparation method thereof

Abstract

The invention provides hydrogel for repairing endometrium injury. The hydrogel is prepared from amination aloe polysaccharide-glyceraldehyde gel, heparin-poloxamer gel containing heparin high-affinitycytokines, and an endometrial acellular matrix, and the mechanical strength and the degradation rate of the hydrogel for repairing endometrium injury are controlled by changing the component ratio. The hydrogel for repairing endometrium injury has low immunogenicity and multiple advantages such as rapid endometrium repair, provides the optimal physicochemical and biological microenvironments forendometrium repair, effectively guides cell directional arrangement, has good mechanical properties, and rapidly repairs endometrium injury.

Description

technical field

[0001] The invention relates to a hydrogel for repairing endometrial damage, in particular to the composition, preparation and application of a hydrogel for repairing endometrial damage. Background technique

[0002] The uterus is the place where menstruation occurs and the fetus is conceived. The normal endometrium can repair and regenerate itself, and plays a pivotal role in female physiological and reproductive functions. However, serious endocrine disorders, intrauterine infection, and uterine surgery can cause endometrial damage, thereby destroying the normal structure of the endometrium. Once the basal layer of the endometrium is damaged, the regeneration of epithelial and mesenchymal cells will be impaired, the formation of new blood vessels will be damaged, and the self-repair function of the endometrium will be seriously affected. When the uterine cavity lacks endometrial coverage, fibrosis, scarring, and adhesions may occur on the anterior and post...

Images