Method for building disease model for mice infected with bacterial sepsis and judging disease situations

Abstract

The invention discloses a method for building a disease model for mice infected with bacterial sepsis and judging disease situations and particularly, escherichia coli is adopted for building a disease model of mouse bacteremia. According to the method, through building a relationship between observed symptoms and blood procalcitonin in human body, a mouse bacteremia disease development degree isfirstly innovatively and scientifically divided into six grades, so that the disease development degree of a bacteremia animal disease model is conveniently judged, and a better model building basis is laid for the development of diseases, screening of treatment drugs and scientific evaluation of treatment effects. By adopting the method, the severity degree and the treatment condition of a disease in a mouse can be effectively, scientifically, rapidly and accurately judged; the defects of only taking a death rate as a model building index and insufficiently sensitive and accurate judgment ofthe treatment effects of the screened drugs can be made up better; and the model building method provides a convenient, rapid and accurate judgment method for successfully building a drug screening model for treating bacteremia.

Description

technical field [0001] The invention belongs to the technical field of treating bacteremia infection caused by Escherichia coli, and in particular relates to a method for constructing a disease model of a mouse infected with bacterial sepsis and judging the disease state. Background technique [0002] Bacteremia refers to the bacteria from the outside entering the blood system through the entrance of the body surface or the entrance of infection, multiplying in the blood of the body and spreading throughout the body with the blood flow. The main cause of morbidity and mortality; it is also a difficult problem commonly faced in the field of emergency and severe diseases in my country and even in the world. In the environment where drug-resistant bacteria are increasing, it is undoubtedly worse for ICU wards. In many literatures, among all the cases of sepsis in hospitals, bacteremia caused by drug-resistant E. coli infection accounted for more than 40%. , especially the morta...

AI Technical Summary

Problems solved by technology

Bacterial drug resistance increases the cost of medication for farmers when treating bacteremia caused by drug-resistant bacteria, prolongs the course of treatment, increases the mortality of livestock and poultry, brings greater economic losses to production, and increases the risk of drug residues in livestock and poultry

Therefore, in actual production, it is urgent to establish a septic disease model for the screening and development of drugs for the treatment of septic disease, the construction of a disease model in mice infected with drug-resistant septicemia, and a scientific judgment method for the disease. see the report

Images