A Novel Antimicrobial Peptide and Its Application

An antibacterial peptide, a new type of technology, applied in the application field of new antibacterial peptides and drugs, can solve the problems of the rapid increase of resistant strains of Staphylococcus aureus and other problems

Active Publication Date: 2021-11-05
JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A major challenge in the treatment of these skin and soft tissue infections is the rapid increase in resistant strains of Staphylococcus aureus

Method used

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  • A Novel Antimicrobial Peptide and Its Application
  • A Novel Antimicrobial Peptide and Its Application
  • A Novel Antimicrobial Peptide and Its Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] 1. Materials and methods

[0023] 1.1 Required materials

[0024] Antimicrobial peptide PDK160 (NO 2 -AIPIKAIGKAGKLRAINIANFNFLKPKRK-NH 2 ) was synthesized and preserved by our laboratory. Mupirocin and fusidic acid (purchased from Shanghai Anhante Biomedical Technology Co., Ltd.) were used as controls. In the in vitro drug resistance test, gentamicin (purchased from Sangon Bioengineering (Shanghai) Co., Ltd.) was used as a control antibiotic. The microorganisms used in the present invention were all purchased from the China Industrial Microbiology Culture Collection and Management Center, and the numbers are shown in Table 1. Specific pathogen-free mice and rats selected for the test were purchased from Beijing Huafukang Biotechnology Co., Ltd. (Experimental animal production license number: BJXK (Beijing) 2013-0016; Experimental animal use license number: BJXK (Beijing) 2016-0012). Human red blood cells were purchased from Shanghai Blood Biomedicine Co., Ltd. ...

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Abstract

The invention belongs to the field of biomedicine and relates to a novel antibacterial peptide and its application. The amino acid sequence of the novel antibacterial peptide is shown in SEQ ID NO:1. The novel antimicrobial peptide of the present invention has broad killing activity on Gram-positive bacteria and Gram-negative bacteria, and the potential anti-infection effect has been proved in the excised wound model in mice and the pig skin model in vitro.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to a novel antibacterial peptide and the application of the novel antibacterial peptide in the preparation of medicines for treating skin and / or soft tissue infections. Background technique [0002] Over the past few decades, a large number of skin and soft tissue infections, manifesting as furuncles, carbuncles, abscesses, or cellulitis, have occurred in the outpatient setting. The main causative agent of this infection is Staphylococcus aureus. Staphylococcus aureus is a common gram-positive bacterium that causes a variety of illnesses ranging from minor superficial skin infections to life-threatening illnesses. A major challenge in the treatment of these skin and soft tissue infections is the rapid increase in drug-resistant strains of Staphylococcus aureus. With the increasing antibiotic resistance of Staphylococcus aureus and other microorganisms, there is an urgent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/46A61K38/17A61P31/04A61P31/10A61P17/02
CPCA61K38/00A61P17/02A61P31/04A61P31/10C07K14/463
Inventor 张小蒙周敏
Owner JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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