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A fluorescence spectroscopic drug detection method using nanoporous materials as enhanced substrates

A nanoporous material and fluorescence spectroscopy technology, applied in the field of drug detection, can solve the problems of expensive instruments, inconvenient promotion of chemical analysis methods, and cumbersome operations.

Active Publication Date: 2021-08-31
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the further development of the pharmaceutical industry, the original chemical analysis methods with low sensitivity, cumbersome operation, expensive instruments and inconvenient promotion will be phased out

Method used

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  • A fluorescence spectroscopic drug detection method using nanoporous materials as enhanced substrates
  • A fluorescence spectroscopic drug detection method using nanoporous materials as enhanced substrates

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Experimental program
Comparison scheme
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Embodiment Construction

[0021] 1. Synthesis method of reinforced matrix material

[0022] Using the one-step method of solvent volatilization involved in patent ZL201210093358.4, the synthesis process is as follows: mix and stir the surfactant P12, the metal salt to be doped, ethanol and hydrochloric acid solution until completely dissolved, then add TEOS, stir evenly, and put it into an open Place the mouth container at room temperature until it condenses into a hard solid, cover it with paraffin, volatilize at 60°C for 1-2 days, then roast at 550°C for 6 hours, grind until there is no grainy feeling, and then use it.

[0023] Doped with Nd 2 o 3 Typical TEM images of mesoporous silica materials such as figure 1 As shown, the doping amount is 10%, and the specific surface area of ​​the material is 523m 2 / g, the pore volume is 0.68m 3 / g, the pore size is 3.8nm. Subsequent examples are all experimented with this material.

[0024] 2. Test conditions of fluorescence spectrum

[0025] All the f...

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Abstract

The invention discloses a fluorescence spectrum drug detection method using a nanoporous material as an enhanced matrix, comprising the following steps: (1) synthesis of a fluorescence enhanced matrix material, that is, a metal oxide-doped mesoporous silica material; (2) ) carry out the mensuration of concentration-fluorescence emission spectrum intensity standard curve to target drug standard solution; (3) carry out the mensuration of fluorescence emission spectrum intensity to target drug unknown solution; (4) compare the standard curve that step (2) obtains, determine step The target drug concentration of the unknown solution in (3). The method of the invention simplifies the pretreatment steps in the analysis process, shortens the detection period, and improves the detection sensitivity and accuracy.

Description

technical field [0001] The invention relates to the field of drug detection, in particular to a nanoporous material-enhanced fluorescence spectrum quantitative detection method for micro-to-trace drugs in water, food, and other environmental systems. Background technique [0002] Drugs are a class of substances used to prevent, treat, and diagnose diseases, and to help the body restore normal functions. Drugs are directly related to people's health and even life safety, and their quality is very important. Therefore, it is necessary to comprehensively control the quality of drugs to ensure people's drug safety. Pharmaceutical analysis is an interdisciplinary subject between pharmacy and analytical chemistry, and is an important part of the entire pharmacology. In general, it is a discipline that studies the chemical testing of drugs, drug stability, bioavailability, drug clinical testing, and qualitative and quantitative analysis of active ingredients in Chinese herbal medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/643
Inventor 李俊芳李亚辉李梦晨杨海峰席广成
Owner CHINESE ACAD OF INSPECTION & QUARANTINE