Iodipin and targeted drug compound

A drug compound and targeting technology, applied in the field of bioengineering, can solve problems such as residual tumor cells, incomplete embolization, and poor deposition, and achieve the effects of inhibiting tumor tissue proliferation, reducing side effects, and improving curative effect

Inactive Publication Date: 2019-04-23
太阳雨林(厦门)生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, simple TACE treatment is difficult to completely block the blood supply of tumor tissue and kill all tumor cells.
Some patients have incomplete embolization or poor deposition after TACE, and it is difficult to completely embolize the peripheral parts of larger tumors, and there are often residual tumor cells

Method used

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  • Iodipin and targeted drug compound
  • Iodipin and targeted drug compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of lipiodol targeting drug complex, comprising

[0026] Lipiodol, as an embolic and / or regional targeting agent;

[0027] Targeted drugs to inhibit tumor angiogenesis and / or directly inhibit tumor cells;

[0028] Targeted drugs are targeted and accumulated in the tumor area of ​​the body through lipiodol. As the lipiodol is removed from the body, the targeted drugs are also removed, but as long as the lipiodol exists at the lesion site, the targeted drugs will always exist.

[0029] Wherein, the targeted drug is dissolved in lipiodol by a solvent capable of dissolving the targeted drug.

[0030] Iodized oil is all iodized vegetable oil that meets the requirements under the item of iodized oil in the Pharmacopoeia of the People's Republic of China. Targeted drugs include all small-molecule targeted drugs that have been marketed and are under research, including but not limited to the following drugs: gefitinib, erlotinib, icotinib, crizotinib, afatinib, chromati...

Embodiment 2

[0034] A kind of lipiodol targeting drug complex, comprising

[0035] Lipiodol, as an embolic and / or regional targeting agent;

[0036] Targeted drugs to inhibit tumor angiogenesis and / or directly inhibit tumor cells;

[0037] Targeted drugs are targeted and accumulated in the tumor area of ​​the body through lipiodol. As the lipiodol is removed from the body, the targeted drugs are also removed, but as long as the lipiodol exists at the lesion site, the targeted drugs will always exist.

[0038] It is a water-in-oil emulsion, the lipiodol is an oil phase and a continuous phase, the targeted drug is in a water phase, and the water phase is a dispersed phase. The particle size of the dispersed phase is 1nm-50μm.

[0039] Iodized oil is all iodized vegetable oil that meets the requirements under the item of iodized oil in the Pharmacopoeia of the People's Republic of China. Targeted drugs include all small-molecule targeted drugs that have been marketed and are under research...

Embodiment 3

[0044] A kind of lipiodol targeting drug complex, comprising

[0045] Lipiodol, as an embolic and / or regional targeting agent;

[0046] Targeted drugs to inhibit tumor angiogenesis and / or directly inhibit tumor cells;

[0047] Targeted drugs are targeted and accumulated in the tumor area of ​​the body through lipiodol. As the lipiodol is removed from the body, the targeted drugs are also removed, but as long as the lipiodol exists at the lesion site, the targeted drugs will always exist.

[0048] It is a water-in-oil-in-water complex emulsion, the targeted drug is in the innermost water phase, and lipiodol is in the middle oil phase. The particle size of its dispersed phase is 1nm-50μm.

[0049] Iodized oil is all iodized vegetable oil that meets the requirements under the item of iodized oil in the Pharmacopoeia of the People's Republic of China. Targeted drugs include all small-molecule targeted drugs that have been marketed and are under research, including but not limit...

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Abstract

The invention discloses an iodipin and targeted drug compound. The iodipin and targeted drug compound comprises iodipin and a targeted drug, and the targeted drug is targetingly gathered on an in-vivotumor area through the iodipin. The iodipin is adopted as an embolization agent or an area targeting agent, the targeted drug is taken into the tumor area, the targeted drug is targetingly gathered on the tumor area rather than acts on other non-tumor organ tissue, and therefore the side effects of the targeted drug are relieved. Some targeted drugs with an angiogenesis restraining function can restrain angiogenesis caused by inflammatory factor releasing caused by iodipin embolism, and therefore hyperplasia of residual tumor tissue causd by iodipin embolism embolism is restrained.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to an lipiodol-targeted drug compound. Background technique [0002] Transcatheter arterial chemoembolization (TACE) is one of the main methods for the treatment of hypervascular tumors, especially advanced liver cancer, and has been widely recognized for its effectiveness and safety. The embolic agent used in traditional TACE treatment is lipiodol, or a mixed emulsion of lipiodol and other chemotherapeutic drugs. Lipiodol and iodized oil carry chemotherapeutic drugs and are trapped in tumor cells to kill tumor cells. Typically, lipiodol remains in hepatocellular carcinoma (HCC) lesions for 8–12 months and can be washed out from normal or cirrhotic hepatic parenchymal cells within 4 weeks. However, TACE treatment alone is difficult to completely block the blood supply of tumor tissue and kill all tumor cells. Some patients have incomplete embolization or poor d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
CPCA61L24/0005A61L24/001A61L24/0015A61L2300/416A61L2400/06
Inventor 赵一麟周媛媛
Owner 太阳雨林(厦门)生物医药有限公司
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