An Ultrasound-Guided Imaging Method for Photoacoustic Microscopy with Low Reflection Artifacts

Abstract

The invention discloses an ultrasound-guided photoacoustic microscope imaging method with low reflection artifacts. Ultrasound is used as guidance to realize the low-artifact transcranial photoacoustic microscope imaging method. When doing photoacoustic imaging of small animal brains, photoacoustic signals will produce multiple reflections when passing through the skull, resulting in serious artifacts. The present invention uses a photoacoustic-ultrasonic dual-mode microscope system to collect photoacoustic signals and ultrasonic signals at each position. Utilizing the similar transfer characteristics of ultrasound reflection signals and photoacoustic signals when passing through the skull, the ultrasound reflection signals are used to estimate the photoacoustic transfer function, and the reflection artifacts in the photoacoustic image are removed by deconvolution algorithm. The imaging method proposed by the present invention can non-invasively obtain high-quality three-dimensional photoacoustic images through the skull.

Description

technical field [0001] The invention relates to a transcranial photoacoustic microscope imaging method using ultrasonic echo as guidance to realize low artifacts. Specifically, on the basis of a dual-mode microscope combining ultrasonic microscopy and photoacoustic microscopy, the ultrasonic echo signal and the photoacoustic signal have similar transcranial transfer functions, and the ultrasonic echo is used to estimate the photoacoustic transfer function. , and correct the results of photoacoustic imaging, so as to suppress the reflection artifacts of photoacoustic transcranial imaging and improve the imaging quality. Background technique [0002] Photoacoustic imaging is a rapidly developing biomedical imaging technique, which not only has rich optical absorption contrast, but also has large imaging depth and good spatial resolution. Acoustic resolution photoacoustic microscopy is an important implementation of photoacoustic imaging. Under the irradiation of pulsed laser...

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: To solve the problem of reflection artifacts in existing photoacoustic microscope transcranial imaging, the present invention provides a new photoacoustic microscope imaging method that uses ultrasonic echoes as a guide to eliminate reflection artifacts, which can significantly improve the quality of photoacoustic imaging ; This method combines two technologies of photoacoustic microscopy and ultrasonic microscopy, which can effectively remove reflection artifacts in photoacoustic signals, and provide a favorable basis for accurately identifying small animal brain information

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