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Polyvinyl alcohol hydrogel as well as preparation method and application thereof

A polyvinyl alcohol and hydrogel technology, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, can solve the problems of non-degradable polymers and high cytotoxicity, and achieve improved The effect of drug availability

Active Publication Date: 2019-04-26
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure polyethyleneimine still has many defects, such as relatively high cytotoxicity, non-degradable polymer, etc.

Method used

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  • Polyvinyl alcohol hydrogel as well as preparation method and application thereof
  • Polyvinyl alcohol hydrogel as well as preparation method and application thereof
  • Polyvinyl alcohol hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of polyvinyl alcohol hydrogel, comprising the steps of:

[0038] (1) Prepare polyvinyl alcohol aqueous solution: add 10g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0039] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 2% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 2.5% and 50 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water at a centrifugal speed of 10,000 r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate microsphere com...

Embodiment 2

[0049] A preparation method of polyvinyl alcohol hydrogel material, comprising the steps of:

[0050] (1) Prepare polyvinyl alcohol aqueous solution: add 15g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0051] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 2% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 2.5% and 100 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water, and the centrifugal speed is 10000r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate mic...

Embodiment 3

[0057] A preparation method of polyvinyl alcohol hydrogel material, comprising the steps of:

[0058] (1) Prepare polyvinyl alcohol aqueous solution: add 20g polyvinyl alcohol into 100mL deionized water, stir until dissolved at 90°C to obtain polyvinyl alcohol aqueous solution, save it for later use;

[0059] (2) Preparation of loaded oridin / sodium alginate microsphere complex: mix 1mL Tween 80 and 100mL olive oil, stir at room temperature at 800r / min for 1h, add 20mL sodium alginate aqueous solution with a mass concentration of 3% dropwise into the olive oil, continue to stir at room temperature for 1 hour, and finally add calcium chloride solution with a mass concentration of 5% and 100 mg oridin and stir overnight; the solution is washed three times by centrifugation with isopropanol and deionized water, and the centrifugal speed is 10000r / min. Centrifuge for 15 minutes each time, and finally freeze-dry at -60°C for 24 hours to obtain the loaded oridin / sodium alginate micro...

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Abstract

The invention relates to polyvinyl alcohol hydrogel as well as a preparation method and application thereof and belongs to the technical field of high molecular hydrogel. The preparation method comprises the following steps of: dropwise adding oridonin into a sodium alginate microsphere solution; performing treating to obtain an oridonin / sodium alginate microsphere compound; carrying out EDC / NHS (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / N-hydroxysuccinimide) activation reaction to prepare a polyethylenimine derivative carrier for loading micro RNA (Ribonucleic Acid); finally, uniformly mixing the oridonin / sodium alginate microsphere compound and a micro RNA / polyethylenimine derivative carrier with a polyvinyl alcohol solution and repeatedly freezing and thawing to form ahydrogel material. According to the polyvinyl alcohol hydrogel, the oridonin / sodium alginate microsphere compound and the micro RNA / polyethylenimine derivative carrier loaded on the hydrogel have drug slow release and micro RNA regulation and control functions; the medicinal availability of the oridonin can be improved; the polyvinyl alcohol hydrogel has a gene treatment effect and can be appliedto skin wound dressing.

Description

technical field [0001] The invention relates to a polyvinyl alcohol hydrogel and a preparation method and application thereof, belonging to the technical field of polymer hydrogels. Background technique [0002] The skin is located on the surface of the human body and is one of the largest and most important organs in the human body. Since the skin is exposed to the external environment for a long time, it may be damaged at all times. When the trauma is very serious, such as burns, severe frostbite, mechanical trauma, ulcers caused by chronic diseases, etc., it not only brings pain to the patient, but even leads to death. Compared with traditional dressings, it is necessary to develop new dressings that can promote healing. [0003] Polyvinyl alcohol (PVA) is a long-chain water-soluble polymer obtained by hydrolysis of polyvinyl ester. It is non-toxic, tasteless, non-irritating to the skin, does not cause skin allergies, and has good film-forming properties and adhesive pr...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K9/06A61K47/32A61K47/36A61K47/34A61K31/352A61K31/7105A61P17/02
CPCA61K9/06A61K31/352A61K31/7105A61K47/32A61K47/34A61K47/36A61L26/0014A61L26/0019A61L26/0023A61L26/0066A61L26/008A61L26/0085A61L2300/216A61L2300/258A61L2300/412A61L2300/602A61P17/02C08L29/04C08L5/04C08L79/02A61K2300/00
Inventor 刘玉蓝咏马春铭陈泰瀛
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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