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Material used for artificial bones and drug carriers and preparation method thereof

A technology for artificial bone and medicine, which is applied in the field of artificial bone and drug carrier materials and its preparation, and can solve problems such as increased product cost, high crystallinity of hydroxyapatite, and inconvenient management of manufacturers

Inactive Publication Date: 2019-04-30
关茜茹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are basically two methods for preparing hydroxyapatite. One is chemical synthesis and high-temperature calcination. The hydroxyapatite obtained by this method has a high degree of crystallinity, and the clinical multi-reaction degradation rate is too slow, making it difficult to rebuild bones; the other is animal collagen. Protein co-precipitation method is biomimetic. The hydroxyapatite obtained by this method has low crystallinity, which is conducive to degradation and absorption in the body. However, the material obtained by this method is an active material, and the procurement of raw materials is very strict, which brings a lot of management to the manufacturer. inconvenience, which increases the cost of the product
In addition, artificial bone with low crystallinity will degrade too quickly when implanted in the body, which is equivalent to rapid sodium loss or interpreted as premature osteoporosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Measure 100ml of collagen solution with a concentration of 0.5%, put it into a dialysis bag with a molecular weight cut-off of 1000, and the concentration of acetic acid is 0.01mol / L. At the same time, measure 500ml of 0.02mol / L sodium chloride solution, drop 0.38ml of concentrated phosphoric acid into it, and finally weigh 0.77g of sodium hydroxide and pour it into the mixed solution of sodium chloride and phosphoric acid, and stir rapidly. And put into a dialysis bag with collagen solution. Stir for 12 hours in an environment with a temperature of 23° C., and take out the dialysis bag. The finally obtained white solution is filtered through a 0.45 μm filter membrane to obtain low-crystalline nano-hydroxyapatite. The mass ratio of collagen to sodium chloride is 1:2.2; the mass ratio of sodium chloride to sodium hydroxide is 10:7.

Embodiment 2

[0014] Measure 100ml of collagen solution with a concentration of 5.0%, put it into a dialysis bag with a molecular weight cut-off of 1000, and the concentration of acetic acid is 0.2mol / L. At the same time, measure 500ml of 0.02mol / L sodium chloride solution, drop 0.38ml of concentrated phosphoric acid into it, and finally weigh 1.0g of sodium hydroxide and pour it into the mixed solution of sodium chloride and phosphoric acid, and stir rapidly. And put into a dialysis bag with collagen solution. Stir for 24 hours in an environment with a temperature of 10° C., and take out the dialysis bag. The finally obtained white solution is filtered through a 0.45 μm filter membrane to obtain low-crystalline nano-hydroxyapatite. The mass ratio of collagen to sodium chloride is 5:1; the mass ratio of sodium chloride to sodium hydroxide is 1.1:1.

Embodiment 3

[0016] Measure 100ml of collagen solution with a concentration of 10.0%, and put it into a dialysis bag with a molecular weight cut-off of 1000, and the concentration of acetic acid is 0.5mol / L. At the same time, measure 400ml of 2.0mol / L sodium chloride solution, drop 30.4ml of concentrated phosphoric acid into it, and finally weigh 77.0g of sodium hydroxide and pour it into the mixed solution of sodium chloride and phosphoric acid, and stir rapidly. And put into a dialysis bag with collagen solution. Stir for 0.5 h in an environment with a temperature of 8° C., and take out the dialysis bag. The finally obtained white solution is filtered through a 0.45 μm filter membrane to obtain low-crystalline nano-hydroxyapatite. The mass ratio of collagen to sodium chloride is 1:8.8; the mass ratio of sodium chloride to sodium hydroxide is 8:7.

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Abstract

The invention provides a material used for artificial bones and drug carriers and a preparation method thereof, belongs to the field of medical biomaterials, and mainly solves the problems of high crystallinity and difficult degradation of hydroxyapatite produced by calcination at high temperature and used currently in clinic and difficult control of biomimetic active materials of hydroxyapatite,as well as the problems of good drug carriers for prevention and treatment of osteoporosis. The purposes of helping bone healing and preventing and treating osteoporosis are achieved by providing hydroxyapatite having an effect of inducing bone formation for a receptor and injecting drug fluorine after implantation. The material prepared by the method is a stable, uniform, low-crystallinity and good-biocompatibility material which is prepared by a method comprising the steps of isolating collagen and inorganic sodium vinegar by a dialysis bag with a certain molecular weight rejection, placingcollagen in the dialysis membrane with the characteristic of large molecular weight of the collagen and modulating and mineralizing sodium ions outside a dialysis membrane. The material helps bone healing in patients with bone disease.

Description

technical field [0001] The invention relates to a material which can be used for artificial bone and drug carrier and a preparation method thereof. This product is low crystalline nanoscale. It can be used for artificial bone and drug carrier. It belongs to the field of medical biomaterials. Background technique [0002] The main raw material of artificial bone currently on the market is hydroxyapatite. Because of its inductive effect on osteogenesis and good biocompatibility, it has attracted wide attention. There are basically two methods for preparing hydroxyapatite. One is chemical synthesis and high-temperature calcination. The hydroxyapatite obtained by this method has a high degree of crystallinity, and the clinical multi-reaction degradation rate is too slow, making it difficult to rebuild bones; the other is animal collagen. Protein co-precipitation method is biomimetic. The hydroxyapatite obtained by this method has low crystallinity, which is conducive to degr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/24A61L27/02A61L27/54
CPCA61L27/12A61L27/025A61L27/24A61L27/54A61L2300/412A61L2430/02
Inventor 关茜茹
Owner 关茜茹
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