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A kind of sodium isethionate ellipsoidal crystal and preparation method thereof

A sodium isethionate, ellipsoid technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as uneven distribution, poor formulation performance, and small particle size

Active Publication Date: 2022-04-22
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to develop a new product aimed at the problems of small particle size, uneven distribution, low bulk density, poor preparation performance, large aspect ratio, and easy fracture in the existing production technology of sodium isethionate crystal products. A method for preparing sodium isethionate crystal product with good crystallographic properties

Method used

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  • A kind of sodium isethionate ellipsoidal crystal and preparation method thereof
  • A kind of sodium isethionate ellipsoidal crystal and preparation method thereof
  • A kind of sodium isethionate ellipsoidal crystal and preparation method thereof

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Effect test

Embodiment 1

[0034] A suspension of sodium isethionate with a concentration of 40% in water was prepared, 500 ppm of gallic acid was added thereto, the temperature was raised to 85° C., and the system was stirred to dissolve. The pressure of the system was controlled by a diaphragm vacuum pump, and gradually decreased linearly from 0.1 MPa to 0.01 MPa within 1 hour, and the system was concentrated to 56%. Stop stirring and grow the crystal for 1h. Then, the temperature was gradually and linearly lowered to 25° C. in a constant temperature bath at a cooling rate of 6° C. / h. After centrifuging, washing and spray-drying the crystalline slurry liquid, ellipsoidal sodium isethionate crystals are obtained. The main particle size of the product is 520 μm, and the bulk density is 1.10 g / mL.

Embodiment 2

[0036] Prepare a suspension of sodium isethionate with a concentration of 50% in water, add 10,000 ppm of gallic acid therein, heat up to 95° C., and stir to dissolve the system. The pressure of the system was controlled by a diaphragm vacuum pump, and gradually decreased linearly from 0.1 MPa to 0.01 MPa within 4 hours, and the system was concentrated to 63%. Stop stirring and grow the crystal for 3h. Then, the temperature was gradually and linearly lowered to 15° C. in a constant temperature bath at a cooling rate of 30° C. / h. After centrifuging, washing and spray-drying the crystalline slurry liquid, ellipsoidal sodium isethionate crystals are obtained. The main particle size of the product is 708 μm, and the bulk density is 1.31 g / mL.

Embodiment 3

[0038] A suspension of sodium isethionate with a concentration of 42% in water was prepared, 2000 ppm of gallic acid was added thereto, the temperature was raised to 90° C., and the system was stirred to dissolve. The pressure of the system was controlled by a diaphragm vacuum pump, and gradually decreased linearly from 0.1 MPa to 0.01 MPa within 2 hours, and the system was concentrated to 58%. Stop stirring and grow the crystal for 2h. Then, the temperature was gradually and linearly lowered to 20° C. in a constant temperature bath at a cooling rate of 10° C. / h. After centrifuging, washing and spray-drying the crystalline slurry liquid, ellipsoidal sodium isethionate crystals are obtained. The main particle size of the product is 572 μm, and the bulk density is 1.14 g / mL.

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Abstract

The invention discloses a sodium isethionate ellipsoidal crystal and a preparation method thereof. Add the crude sodium isethionate into water to make a suspension with a certain concentration, then add a certain proportion of gallic acid as an additive, raise the temperature to 80-100°C, and stir to dissolve the system. The sodium isethionate solution was evaporated and concentrated to a certain extent by means of programmed decompression. Then grow the crystal for a period of time, and then lower the temperature of the system to 10-25°C by means of program temperature control. After centrifugation, washing and drying, ellipsoidal sodium isethionate crystals can be obtained. The main particle size of the ellipsoidal crystal is 500 μm-700 μm, and the bulk density is 1.10 g / mL-1.30 g / mL. The method has high production efficiency, simple technological process and easy industrialization.

Description

technical field [0001] The invention relates to the technical field of chemical and pharmaceutical crystallization, in particular to a sodium isethionate ellipsoidal crystal and a preparation method thereof. Background technique [0002] Taurine, a natural and pure β-sulfonated amino acid, is a sulfur-containing amino acid necessary for human and mammalian body activities. Although it does not directly participate in the synthesis of proteins and enzymes in the body, it is widely used in the food and pharmaceutical industries because of its important physiological functions such as treating fatty liver, relieving heart failure, and eliminating fatigue. [0003] The synthetic methods of taurine mainly include ethanolamine method and ethylene oxide method. Among them, the ethanolamine method is gradually eliminated due to long reaction cycle, low conversion rate and high cost. The ethylene oxide method has a high conversion rate and convenient continuous production, and has ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C303/44C07C309/08
CPCC07C303/44C07C309/08
Inventor 赵凯飞郭斌张静桂振友蔺海政梁静丰茂英李冰钰陈来中张永振黎源
Owner WANHUA CHEM GRP CO LTD
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