High efficiency liquid chromatograph analysis method for sodium isethionate

A technology of high performance liquid chromatography and sodium isethionate, which is applied in the field of high performance liquid chromatography analysis of sodium isethionate, can solve the problem that the use of ion chromatography is not as popular as that of high performance liquid chromatography, there is no standard release, and there are no articles Reporting and other issues, to achieve the effect of high sensitivity, fast speed and high efficiency

Inactive Publication Date: 2009-09-02
JIANGNAN UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there has been no article report on the content determination of residual SI in the Igepon A quality index, let alone the release of relevant standards
Ion chromatography is currently a relatively mature method for the analysis of sulfonate content, but the use of ion chromatography is far less popular than high-performance liquid chromatography

Method used

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  • High efficiency liquid chromatograph analysis method for sodium isethionate
  • High efficiency liquid chromatograph analysis method for sodium isethionate
  • High efficiency liquid chromatograph analysis method for sodium isethionate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] laboratory apparatus:

[0025] WATERS1525 high performance liquid chromatograph (Waters, USA);

[0026] Waters2420 type evaporative light scattering detector (Waters, USA);

[0027] Empower chromatography workstation;

[0028] Ultrasonic cleaner, Shanghai Kedao Ultrasonic Instrument Co., Ltd.;

[0029] JA1004 electronic balance (1 / 10000 balance) (Shanghai Precision Scientific Instrument Co., Ltd.);

[0030] Dionex OnGuard IIRP pre-treatment pre-column (Dionex, USA);

[0031] Dionex 500 ion chromatograph (Dionex, USA);

[0032] DionexAG11-AS11-HC separation column (Dionex, USA);

[0033] Dionex conductivity detector (Dionex, USA).

[0034] Chromatographic conditions:

[0035] Chromatographic column: 250mm×4.6mm(id) stainless steel column, Lichrospher-5μm-C 18 filler;

[0036] Mobile phase composition volume ratio: methanol: ultrapure water = 100:0;

[0037] Flow rate: 0.4mL / min;

[0038] Column temperature: 25°C;

[0039] Evaporative light scattering detector...

Embodiment 2

[0076] Chromatographic conditions:

[0077] Chromatographic column: 250mm×4.6mm(id) stainless steel column, Lichrospher-5μm-C 18 filler;

[0078] Mobile phase composition volume ratio: methanol: ultrapure water = 100:0;

[0079] Flow rate: 0.8mL / min;

[0080] Column temperature: 25°C;

[0081] Evaporative light scattering detector;

[0082] Spray chamber level of the detector: 60%;

[0083] Drift tube temperature: 40°C;

[0084] Nitrogen pressure: 20psi;

[0085] The injection volume was 20 μL.

[0086] All the other implementations are the same as in Example 1.

[0087] 1. Standard curve and linear relationship

[0088] Precisely draw the SI standard solution in Step 2 of Example 1, place it in a volumetric flask, and constant volume with methanol to obtain mass concentrations of 0.004mg / mL, 0.02mg / mL, 0.04mg / mL, 0.08mg / mL, 0.1mg SI standard solutions of / mL, 0.2mg / mL, 0.4mg / mL, 0.6mg / mL, 0.8mg / mL and 1.0mg / mL were measured according to the above chromatographic con...

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Abstract

The invention provides a high efficiency liquid chromatograph analysis method for sodium isethionate, which relates to an HPLC-ELSD analysis method for analyzing the content of impurities of fatty acyl sulfonate. The invention makes use of the high efficiency liquid chromatography analysis method and an evaporative light-scattering detector to measure the content of the sodium isethionate with a standard curve method; and a sample is dissolved with methanol, methanol-water is used as a mobile phase, a stainless steel column using Lichrospher-C18 as a filler and the evaporative light-scattering detector are used, the recovery rate is between 95.2 and 98.3 percent, the detection limit is 0.02 mu g / mL, and the precision RSD is less than 3.00 percent. The method uses popularized instruments and has simple steps, and the measuring result is verified by the conventional ion chromatography method, is correct and reliable, and has high sensitivity and good reproducibility. The invention discloses a sensitive, rapid and simple high efficiency liquid chromatograph method for detecting the content of the sodium isethionate (SI), which controls the SI content in the formulation of a solid synthetic detergent soap to further play an important role in quality control of products.

Description

technical field [0001] A high performance liquid chromatography analysis method for sodium isethionate, the invention relates to a high performance liquid chromatography evaporative light scattering detector (HPLC-ELSD) analysis method. Specifically, it relates to the analysis of the content of fatty acyl sulfonate impurities by HPLC-ELSD analysis. Background technique [0002] Igepon A (Igepon A) is a relatively less irritating anionic surfactant. It is not sensitive to hard water, has good foam performance and detergency, and has good affinity to human skin. It is widely used in cosmetics and in detergent formulations. The raw materials for the production of Igepon A are mainly fatty acids (mostly coconut oleic acid) and sodium isethionate (SI). When producing Igepon A, it is very important to determine the residual amount of SI that does not participate in the esterification in the product for the finishing stage of the soap making process. If the amount of SI in the so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/74G01N21/51
Inventor 孙培冬王建新杨敏周忠曹光群杨成
Owner JIANGNAN UNIV
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