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Arctigenin preparation

A technology of arctigenin and preparations, which is applied in the field of medicine, can solve the problems of low bioavailability, poor water solubility, and poor water solubility of arctigenin, and achieve the effects of high safety, increased drug dissolution rate, and simple operation

Pending Publication Date: 2019-05-07
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to literature reports, the bioavailability of arctigenin in rabbits by intragastric administration is only 9.5%. The main reason for the analysis is that arctigenin is a fat-soluble compound with poor water solubility, resulting in very low oral bioavailability
Chinese invention patent CN101036644A discloses a pharmaceutical composition containing arctigenin, which includes arctigenin in cyclodextrin derivatives to solve the problem of poor water solubility and low bioavailability of arctigenin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] Preparation Process:

[0035] Arctigenin was crushed through a 100-mesh sieve, added to the aqueous solution of sodium carboxymethylcellulose and hydroxypropyl β-cyclodextrin, stirred evenly, and ground by a bead mill for 45 minutes, D90=250nm, and then mixed The suspension is spray-dried on the microcrystalline cellulose ball core through a fluidized bed, and finally packed into a capsule shell to obtain the product.

Embodiment 2

[0037]

[0038] Preparation Process:

[0039] Arctigenin was crushed through a 120-mesh sieve, added to the aqueous solution of sodium carboxymethylcellulose and hydroxypropyl β-cyclodextrin, stirred evenly, and ground by a bead mill for 60 minutes, D90=220nm, and then mixed The suspension is spray-dried on the microcrystalline cellulose ball core through a fluidized bed, and finally packed into a capsule shell to obtain the product.

Embodiment 3

[0041]

[0042] Preparation Process:

[0043] Arctigenin was crushed through a 100-mesh sieve, added to the aqueous solution of sodium carboxymethylcellulose and hydroxypropyl β-cyclodextrin, stirred evenly, and ground by a bead mill for 45 minutes, D90=200nm, and then mixed The suspension is spray-dried on the microcrystalline cellulose ball core through a fluidized bed, and finally packed into a capsule shell to obtain the product.

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Abstract

The invention belongs to the technical field of medicine, and particularly discloses an arctigenin preparation. The preparation contains arctigenin, carboxymethyl cellulose sodium, and hydroxypropyl beta cyclodextrin. A preparation method is as follows: adding the arctigenin into an aqueous solution of the carboxymethyl cellulose sodium and the hydroxypropyl beta cyclodextrin with stirring, performing grinding by a bead mill, then spray-drying a mixed suspension by a fluidized bed onto microcrystalline cellulose pellets, and finally preparing capsules, granules, tablets or other pharmaceutically-acceptable dosage forms. The arctigenin preparation prepared by the method has good stability, rapid dissolution and simple process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an arctigenin preparation. Background technique [0002] Arctium burdock is the dry and ripe fruit of the Compositae plant Burdock. It is a commonly used traditional Chinese medicine. It has the functions of evacuating wind-heat, clearing the lungs and rash, detoxifying and erecting the throat. It is used for wind-heat cold, cough with excessive phlegm, measles, rubella, sore throat, Pruritus mumps erysipelas, carbuncle sores. The traditional Chinese medicine contains lignin compounds, mainly arctiin and arctigenin. Although the content of arctigenin (also known as arctigenin) in arctium is very low, but its precursor arctiin is high in the traditional Chinese medicine burdock and burdock burdock fruit, so a large amount of arctiin can be obtained through the conversion of arctiin aglycone. According to literature reports, arctiin is decomposed into arctigenin in ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/48A61K47/38A61K47/40A61K31/365A61P31/04A61P31/12A61P35/00
Inventor 张贵民郝贵周李倩
Owner LUNAN PHARMA GROUP CORPORATION