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Microfluidic chip applied to microbubble separation

A microfluidic chip and microbubble separation technology, applied in laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve the problems of inability to separate microbubbles, and achieve the effect of low cost and simple production

Active Publication Date: 2019-05-17
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method can only move the microbubbles, and cannot separate the microbubbles.

Method used

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  • Microfluidic chip applied to microbubble separation
  • Microfluidic chip applied to microbubble separation
  • Microfluidic chip applied to microbubble separation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Using a 405nm laser, the laser power is 24.77mW, and the magnification of the objective lens is 25 times. The generated microbubbles with a volume of 10.00pL are introduced into the microchannel, so that the focused spot hits the center of the microbubbles. The volumes of the separated small bubbles are respectively 6.40pL and 3.60pL.

Embodiment 2

[0027] Using a 473nm laser, the laser power is 27.90mW, and the magnification of the objective lens is 25 times. The generated microbubbles with a volume of 10.56pL are introduced into the microchannel, so that the focused spot hits the center of the microbubbles, and the volume of the separated small bubbles is 5.90 pL and 4.66pL.

Embodiment 3

[0029] Using a 532nm laser, the laser power is 37.44mW, and the magnification of the objective lens is 25 times. The generated microbubbles with a volume of 9.88pL are introduced into the microchannel, so that the focused spot hits the center of the microbubbles, and the volume of the separated small bubbles is 5.32 pL and 4.56pL.

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Abstract

The invention discloses a microfluidic chip applied to microbubble separation. The chip is mainly bonded by two chips prepared from polydimethylsiloxane (PDMS) and C-cut lithium niobate, wherein an upper chip comprises a liquid injection hole, a gas injection hole, a micro channel and a liquid outlet; and a material of a lower chip is a C-cut lithium niobate wafer. The microfluidic chip realizes separation of microbubbles in the micro channel through utilizing laser radiation on an electric field generated by the C-cut lithium niobate wafer. The chip is simple in production method and controllable in separation parts and separation time of the microbubbles, can be applied to separation of gas phase carriers in medical and environmental analysis processes, completes a microbubble separationtechnology in the field of microfluidic control, and is of important significance to completion of functions of the microfluidic chip.

Description

technical field [0001] The invention relates to the control field of a microfluidic chip, in particular to a microfluidic chip used for separating microbubbles in a microchannel. Background technique [0002] Microfluidic chip technology integrates basic operations such as preparation, mixing, reaction, and detection of biological and chemical samples on a tiny chip. It has great research value in the fields of biology, chemistry and medicine. With the continuous development of microfluidic technology, the manipulation techniques for different objects are becoming more and more diverse. As an important carrier, air bubbles are involved in many applications such as drug detection and air quality detection. The development of its manipulation technology is critical to the improvement of the functions of microfluidic chips. [0003] In 2015, Micheal Esseling (Optofluidic droplet router) and others used lithium niobate wafer as the substrate, and realized the movement of micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 昝知韬阎文博高作轩
Owner HEBEI UNIV OF TECH